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dc.rights.licenseAtribución-NoComercial 4.0 Internacional
dc.contributor.authorRodrigues de Oliveira, Clayton
dc.contributor.authorSevero Menezes, Antânio Calos
dc.contributor.authorO. de Moraes, Manoel
dc.contributor.authorde Melo Vieira, Letícia
dc.contributor.authorGomes Pereira, Adriana
dc.contributor.authorSilva Lima, Rosa
dc.contributor.authordos Santos, Mirley Luciene
dc.date.accessioned2019-06-29T08:34:38Z
dc.date.available2019-06-29T08:34:38Z
dc.date.issued2012
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/49309
dc.description.abstractFor millennia humans have been using plants for medicinal purposes to treat, cure, or prevent diseases, including cancer. Brazilian ecosystem has a high diversity of plant species. From this perspective, a species found in the Cerrado, Salacia crassifolia (Celastraceae), was selected, for an initial screening to determine the cytotoxic potential of this species "in vitro". S. crassifolia has been widely used in traditional medicine to treat kidney diseases, chronic cough, headaches, healing, ulcerogenic, and for treatment of malaria. The fractions: hydroalcoholic (SCCcM-W), dichloromethane(SCCcM-D), hexane (SCCcM-H) and ethyl acetate (SCCcM-A) from the stem bark were tested for cytotoxicity "in vitro" to within MDA -MB-435(melanoma), HCT-8 (human-colon), and SF-295 (CNS) using the MTT colorimetric method. The hexane (SCCcM-H) and ethyl acetate (SCCcM-A) fractions were those that provided significant cytotoxicity against analyzed tumor cells.
dc.description.abstractA utilização de plantas pela humanidade com fins medicinais é uma das formas mais antigas para tratamento, cura e prevenção de doenças, dentre elas o câncer, cujas espécies vegetais são encontradas em elevada diversidade no ecossistema. Com essa perspectiva, se optou por um arbusto típico do Cerrado, Salacia crassifolia (Celastraceae), para um screening inicial na determinação do potencial citotóxico desta espécie in vitro. Na medicina popular, S. crassifoliaé utilizada no tratamento de problemas renais, tosse crônica, dores de cabeça, cicatrizantes, ulcerogênicas e na terapia da malaria. As frações: hidroalcoólica (SCCcM-W), diclorometânica(SCCcM-D), hexânica (SCCcM-H) e acetato de etila (SCCcM-A) da casca do caule foram submetidas a testes de citotoxicidade in vitro frente às linhagens MDA-MB-435(melanoma), HCT-8 (cólon-humano) e SF-295 (sistema nervoso central) utilizando o método colorimétrico MTT. As frações hexânica (SCCcM-H) e de acetato de etila(SCCcM-A) foram aquelas que proporcionaram citotoxicidade significativas frente às células tumorais analisadas.
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.publisherRevista Colombiana de Ciencias Químico Farmacéuticas
dc.relationhttp://revistas.unal.edu.co/index.php/rccquifa/article/view/45092
dc.relation.ispartofUniversidad Nacional de Colombia Revistas electrónicas UN Revista Colombiana de Ciencias Químico Farmacéuticas
dc.relation.ispartofRevista Colombiana de Ciencias Químico Farmacéuticas
dc.relation.ispartofseriesRevista Colombiana de Ciencias Químico Farmacéuticas; Vol. 41, núm. 2 (2012); 133-142 0034-7418 1909-6356
dc.rightsDerechos reservados - Universidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.titleAssessment of cytotoxicity in three tumor cell lines of the fractions attained from the stem bark of salacia crassifolia (mart. ex. schult.) g. dom (celastraceae)
dc.typeArtículo de revista
dc.type.driverinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.eprintshttp://bdigital.unal.edu.co/42766/
dc.identifier.eprintshttp://bdigital.unal.edu.co/42766/2/
dc.relation.referencesRodrigues de Oliveira, Clayton and Severo Menezes, Antânio Calos and O. de Moraes, Manoel and de Melo Vieira, Letícia and Gomes Pereira, Adriana and Silva Lima, Rosa and dos Santos, Mirley Luciene (2012) Assessment of cytotoxicity in three tumor cell lines of the fractions attained from the stem bark of salacia crassifolia (mart. ex. schult.) g. dom (celastraceae). Revista Colombiana de Ciencias Químico Farmacéuticas; Vol. 41, núm. 2 (2012); 133-142 0034-7418 1909-6356 .
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.proposalSalacia crassifolia
dc.subject.proposalMDA-MB-435 (melanoma)
dc.subject.proposalHCT-8 (cólon-humano) e SF-295 (sistema nervoso central)
dc.subject.proposalSalacia crassifolia
dc.subject.proposalMDA-MB-435 (melanoma)
dc.subject.proposalHCT-8 (human-colon)
dc.subject.proposaland SF-295 (CNS)
dc.type.coarhttp://purl.org/coar/resource_type/c_6501
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.contentText
dc.type.redcolhttp://purl.org/redcol/resource_type/ART
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2


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Atribución-NoComercial 4.0 InternacionalThis work is licensed under a Creative Commons Reconocimiento-NoComercial 4.0.This document has been deposited by the author (s) under the following certificate of deposit