In order to control the main diseases that affect blackberries (Rubus glaucus Benth.), a research in which 12 treatments to San Antonio ecotype plants originated in vitro was conducted. These treatments were: 1: Trichoderma harzianum+richoderma koningii (Tropical Fungus), 2: Trichoderma sp. (Bioprotection), 3: Trichoderma koningiopsis (Th003 Trichoderma), 4: Trichoderma asperellum (Th034 Trichoderma), 5: Trichoderma asperellum (T-30 Trichoderma), 6: Trichoderma asperellum (T-98 Trichoderma), 7:Burkholderia cepacia (Botrycid), 8: extract of Swinglea glutinosa (Ecoswin), 9: traditional farming treatments (Mancozeb, Propamocarb), 10: chemical products applications (Mancozeb, Mandipropamida, Carbendazim, Propamocar and Metalaxil+Mancozeb) alternated according to the impact of the disease, 11: chemical products applications alternated with organic products according to the suppliers recommendations and presence of the diseases, 12: absolute control, no treatment was applied to the plants. The applications were carried out every 15 days, each plant was an experimental unit and each treatment was made of five experimental units. 12 treatments were made through a RCBD (randomized complete block design) with three repetitions for a total of 15 experimental units per treatment. The assessments were performed every 8 days, and the variables were: number of healthy and sick fruits/treatment, costs/treatment and gross profit. A variance analysis and a Tukey test 5% were made. The best treatments were T11 (rotation of chemicals with biological products), T10 (rotation of chemical products according to the impact of the disease) and T3 (T. koningiopsis); considering the obtained performance/treatment, treatment cost and profit.In order to control the main diseases that affect blackberries (Rubus glaucus Benth.), a research in which 12 treatments to San Antonio ecotype plants originated in vitro was conducted. These treatments were: 1: Trichoderma harzianum+richoderma koningii (Tropical Fungus), 2: Trichoderma sp. (Bioprotection), 3: Trichoderma koningiopsis (Th003 Trichoderma), 4: Trichoderma asperellum (Th034 Trichoderma), 5: Trichoderma asperellum (T-30 Trichoderma), 6: Trichoderma asperellum (T-98 Trichoderma), 7:Burkholderia cepacia (Botrycid), 8: extract of Swinglea glutinosa (Ecoswin), 9: traditional farming treatments (Mancozeb, Propamocarb), 10: chemical products applications (Mancozeb, Mandipropamida, Carbendazim, Propamocar and Metalaxil+Mancozeb) alternated according to the impact of the disease, 11: chemical products applications alternated with organic products according to the suppliers recommendations and presence of the diseases, 12: absolute control, no treatment was applied to the plants. The applications were carried out every 15 days, each plant was an experimental unit and each treatment was made of five experimental units. 12 treatments were made through a RCBD (randomized complete block design) with three repetitions for a total of 15 experimental units per treatment. The assessments were performed every 8 days, and the variables were: number of healthy and sick fruits/treatment, costs/treatment and gross profit. A variance analysis and a Tukey test 5% were made. The best treatments were T11 (rotation of chemicals with biological products), T10 (rotation of chemical products according to the impact of the disease) and T3 (T. koningiopsis); considering the obtained performance/treatment, treatment cost and profit.