In this paper a twofold calibration approach for a digital frame sensor has been developed which tries to cope with panchromatic and multispectral calibration separately. Although there have been several improvements and developments in calibration of the digital frame sensor, only limited progresses has been made in the context of multispectral image calibration. To this end, a specific photogrammetric flight was executed to try to calibrate the geometric parameters of a large format aerial digital camera. This photogrammetric flight was performed in the “Principado de Asturias” and it has been designed with a Ground Sample Distance of 6 cm, formed by two strips perpendicular between each other, with five images each one and a longitudinal overlap of 60%. Numerous points have been presignalled over the ground, both check points and control points.