Show simple item record

dc.rights.licenseAtribución-NoComercial 4.0 Internacional
dc.contributor.authorCéspedes Rubio, Angel Enrique
dc.contributor.authorTapiero Hernández, Yacson
dc.contributor.authorRondón Barragán, Iang
dc.date.accessioned2019-07-03T15:10:18Z
dc.date.available2019-07-03T15:10:18Z
dc.date.issued2013
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/72417
dc.description.abstractThe organophosphates used for pest control induce sensory, motor and psychiatric disturbances after chronic exposure. The ester type is the cause of the intermediate syndrome and delayed neuropathy, in which the white and gray matter in the brain are severely affected.The aim of this study was to evaluate the effect of multiple sublethal doses of Trichlorfon on neurons, astrocytes and myelinated tissue in a rat model of brain neurotoxicity. Trichlorfon (metrifonate) was administered to adult Wistar rats at doses of 11 or 22 μg/kg by oral gavage every seven days for four or eight weeks (four experimental groups) and a control group (placebo). One week after the last dose, animals were euthanized and the brains perfused, removed and cut into coronal segments of 50 μm of thickness by using a vibratome. The sections were analyzed by immunohistochemistry, using markers of neuronal survival, astrocytic reactivity and the myelin basic protein. Neuronal and astrocytic reactivity were significantly reduced in Trichlorfon-treated animals relative to controls, whereas myelin reactivity was significantly increased, with abnormal distribution of myelin in white matter. The results suggest a neurotoxic damage of Trichlorfon on neuronal and astrocyte functional balance and abnormal myelin formation consequent to the cell damage.
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.publisherUniversidad Nacional de Colombia, Facultad de Ciencias, Departamento de Biología
dc.relationhttp://revistas.unal.edu.co/index.php/actabiol/article/view/38012
dc.relation.ispartofUniversidad Nacional de Colombia Revistas electrónicas UN Acta Biológica Colombiana
dc.relation.ispartofActa Biológica Colombiana
dc.relation.ispartofseriesActa Biológica Colombiana; Vol. 18, núm. 3 (2013); 479-488 Acta Biológica Colombiana; Vol. 18, núm. 3 (2013); 479-488 1900-1649 0120-548X
dc.rightsDerechos reservados - Universidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.titleNeurotoxic potential of trichlorfon to multiple sublethal doses in wistar rats
dc.typeArtículo de revista
dc.type.driverinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.eprintshttp://bdigital.unal.edu.co/36890/
dc.identifier.eprintshttp://bdigital.unal.edu.co/36890/2/
dc.relation.referencesCéspedes Rubio, Angel Enrique and Tapiero Hernández, Yacson and Rondón Barragán, Iang (2013) Neurotoxic potential of trichlorfon to multiple sublethal doses in wistar rats. Acta Biológica Colombiana; Vol. 18, núm. 3 (2013); 479-488 Acta Biológica Colombiana; Vol. 18, núm. 3 (2013); 479-488 1900-1649 0120-548X .
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.proposalastrocytes
dc.subject.proposalmyelin
dc.subject.proposalneurons
dc.subject.proposalorganophosphates
dc.subject.proposaltoxicology.
dc.type.coarhttp://purl.org/coar/resource_type/c_6501
dc.type.coarversionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.contentText
dc.type.redcolhttp://purl.org/redcol/resource_type/ART
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2


Files in this item

Thumbnail
Thumbnail
Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Atribución-NoComercial 4.0 InternacionalThis work is licensed under a Creative Commons Reconocimiento-NoComercial 4.0.This document has been deposited by the author (s) under the following certificate of deposit