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dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.contributor.advisorMora Huertas, Claudia Elizabeth
dc.contributor.advisorPonce Pedraza, Arturo
dc.contributor.authorGordillo Galeano, Aldemar
dc.date.accessioned2021-01-19T16:36:58Z
dc.date.available2021-01-19T16:36:58Z
dc.date.issued2020-01-16
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/78818
dc.description.abstractLas nanopartículas sólidas lipídicas (SLN) y los transportadores lipídicos nanoestructurados (NLC) han atraído la atención durante más de dos décadas como una alternativa para la entrega de fármacos poco solubles en agua. Sin embargo, a pesar de su presumida relevancia frente a las nanoemulsiones (NE), todavía son escasas las investigaciones relacionadas con la organización estructural de estos sistemas. Este trabajo aborda el estudio de las características estructurales de las SLN, NLC y NE mediante el análisis comparativo de la estructura interna, las características de superficie y el comportamiento liberación. Los resultados muestran que las mezclas de trimiristina (MMM) y triglicérido cáprico/caprílico (TCC) conducen a la formación de una estructura bifásica en la que la MMM forma un cristal \beta rodeado de una fase líquida de MMM y TCC. Durante la cristalización, las moléculas modelo a incorporar (metil y propilparabeno) se concentran en la superficie en donde se distribuyen entre el tensioactivo (Poloxamer® 188) y la fase acuosa, en función de su coeficiente de distribución (logD). La interacción de los segmentos hidrófilos e hidrófobos del tensioactivo con las partículas depende de la proporción de TCC en la matriz lipídica. En las SLN hay un aumento de parches hidrófobos sobre las superficies sólidas mientras que en las NE ocurre interpenetración de los segmentos hidrófobos. El comportamiento de liberación es una consecuencia de la solubilidad de las moléculas en la fase lipídica y de la estructura de dicha fase. Por consiguiente, la liberación in vitro procede en el orden NE-MMM>SLN>NLC>NE-TCC.
dc.description.abstractSolid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) have attracted attention during the last two decades as a delivery method of drugs that are poorly soluble in water. However, despite its presumed relevance against nanoemulsions (NE), there is still little research related to the structural organization of these systems. This work aims the study of the structural characteristics of SLN, NLC, and NE by a comparative analysis of the internal structure, surface characteristics, and drug release. The results show that the mixtures of trimyristin (MMM) and capric/caprylic triglyceride (CCT) lead to the formation of a biphasic structure in which the MMM forms a \beta-crystal surrounded by a liquid phase of MMM and CCT. During crystallization, the model molecules to be entrapped (methyl and propylparaben) are concentrated to the surface where there are distributed between the surfactant (Poloxamer® 188) and the aqueous phase based on their distribution coefficients (logD). The interaction of the hydrophilic and hydrophobic segments of the surfactant with the particles depends on the proportion of CCT in the lipid matrix. In SLN there is an increase in hydrophobic patches on the solid surfaces, while interpenetration of hydrophobic segments occurs in NE. The release behavior is a consequence of the solubility of the molecules in the lipid phase and the lipid phase structure. Accordingly, in vitro release proceeds in the order NE-MMM>SLN>NLC> NE-CCT.
dc.description.sponsorshipDepartamento Administrativo de Ciencia, Tecnología e Innovación-Colciencias; División de Investigación de la Sede Bogotá (DIB) de la Universidad Nacional de Colombia
dc.format.extent318
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.rightsDerechos reservados - Universidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc610 - Medicina y salud::615 - Farmacología y terapéutica
dc.titleEfecto de las propiedades estructurales de la partícula sobre la liberación de moléculas encapsuladas en sistemas lipídicos coloidales
dc.typeOtro
dc.rights.spaAcceso abierto
dc.description.projectConvocatoria 617 para la Formación de Investigadores de Alto Nivel para la Ciencia, la Tecnología y la Innovación; proyectos 28405, 36019 y 40987
dc.description.additionalLínea de Investigación: Farmacotecnia
dc.type.driverinfo:eu-repo/semantics/other
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Ciencias - Doctorado en Ciencias Farmacéuticas
dc.contributor.researchgroupDesarrollo y calidad de productos farmacéuticos y cosméticos
dc.description.degreelevelDoctorado
dc.publisher.departmentDepartamento de Farmacia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.proposalPortadores lipídicos coloidales
dc.subject.proposalColloid lipid carriers
dc.subject.proposalNanoemulsiones
dc.subject.proposalNanoemulsions
dc.subject.proposalStructural organization
dc.subject.proposalOrganización estructural
dc.subject.proposalcomportamiento de liberación
dc.subject.proposalDrug release behavior
dc.subject.proposalDrug incorporation
dc.subject.proposalLocalización del fármaco
dc.subject.proposalLipid nanoparticles
dc.subject.proposalNanopartículas lipídicas
dc.type.coarhttp://purl.org/coar/resource_type/c_1843
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2


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