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dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.contributor.advisorArias Guatibonza, Jaime Andelfo
dc.contributor.authorRamírez Grueso, Raúl
dc.date.accessioned2021-01-28T18:04:10Z
dc.date.available2021-01-28T18:04:10Z
dc.date.issued2021
dc.identifier.citationRamírez, G. (2020). Caracterización de la expresión de receptores de progesterona en meningiomas intracraneales de pacientes tratados quirúrgicamente en una unidad de servicios de salud de alta complejidad en Bogotá – Colombia [Tesis de especialidad, Universidad Nacional de Colombia]. Repositorio Institucional.
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/78967
dc.description.abstractBACKGROUND. Meningiomas are the single most common brain tumor. The incidence of these tumors increases with age; different studies have shown that meningiomas usually appear after the age of 50. These tumors are more common in women than in men, who are twice as likely to suffer from the condition. Surgery is the primary form of treatment, which can be curative with complete resection. If the tumor is unresectable or other treatments such as surgery and radiotherapy have failed, hormonal therapy or chemotherapy may be considered. There is limited information about the clinical, demographic, and histopathological characteristics of these tumors in the population of Bogotá, Colombia. OBJECTIVE: To evaluate the expression of progesterone receptors in patients over 18 years old who have been diagnosed with meningiomas in a high-complexity hospital in Bogota, Colombia, and to describe the demographic and histopathological characteristics of these patients. METHODS: This is a descriptive and retrospective case series. Patients with meningioma who underwent surgical resection at a high-complexity hospital in Bogota, Colombia, from 2016 to 2019 were retrospectively identified and studied. Demographic variables, such as age and gender, were extracted from the clinical chart. Indirect immunoperoxidase staining was carried out for PR (progesterone receptor) and Ki67. PR is analyzed as positive and negative, and Ki67 proliferation index was determined. RESULTS: 32 meningiomas from patients who underwent surgery were available for analysis. 25 (78.1%) were positive to PR. 71.8% were females, and 93% were World Health Organization (WHO) grade I. Meningothelial (28%), fibrous (25%), and transitional (25%) were the most frequent subtypes, correspondingly. Ki67 mean value was 1.14 (0.11-10.71). CONCLUSION: Our case series showed a greater frequency of meningiomas in women, with a high progesterone receptor expression and a low Ki67 proliferation rate. This data correlates with literature worldwide.
dc.description.abstractINTRODUCCIÓN. Los meningiomas son el tumores cerebrales más comunes. Su incidencia aumenta con la edad, alcanza el pico después de la quinta década de la vida y afecta más comúnmente a las mujeres que a los hombres. El tratamiento principal para los meningiomas es la cirugía, la cual puede ser curativa si el tumor es resecado por completo. Cuando el meningioma es irresecable u otros tratamientos, como la cirugía y la radioterapia, han fallado, la terapia hormonal o la quimioterapia podrían ser considerados. Existe información limitada sobre la distribución y las características histopatológicas de estos tumores en nuestra población. OBJETIVO: Evaluar la expresión de receptores de progesterona (PR) en pacientes mayores de 18 años diagnosticados con meningiomas en un hospital de Bogotá, Colombia, y describir las características clínicas, demográficas e histopatológicas de estos pacientes. MÉTODOS: Se identificaron pacientes con diagnostico de meningioma intracraneal que fueron sometidos a resección quirúrgica en nuestra institución de 2016 a 2019 y se estudiaron retrospectivamente. Se extrajeron de la historia clinica variables demográficas, como la edad y el sexo. Se llevó a cabo una tinción con inmunoperoxidasa indirecta para PR y Ki67. El PR se analiza como positivo y negativo y el índice de proliferación ki67 fue determinado. RESULTADOS: El rendimiento de la busqueda feron 32 meningiomas de pacientes que fueron llevados a cirugía y se contaban con datos clinicos completos para su análisis. De estos, 25 fueron positivos para el receptor de progesterona. El 71,8% de los pacientes fueron mujeres y el 93% se diagnosticaron grado I según la OMS. Con respecto a la clasificacion histologica, los subtipos mas frecuentes fueron: Meningotelial (28%), fibroso (25%) y transicional (25%). El valor promedio de Ki67 fue 1,14 (0,11-10,71). CONCLUSIÓN: Esta serie de casos mostró una mayor frecuencia en mujeres, con una alta expresión de receptores de progesterona y una baja tasa de proliferación de ki67. Estos datos se correlacionan con la literatura mundial.
dc.format.extent30
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.rightsDerechos reservados - Universidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc617 - Cirugía, medicina regional, odontología, oftalmología, otología, audiología
dc.titleCaracterización de la expresión de receptores de progesterona en meningiomas intracraneales de pacientes tratados quirúrgicamente en una unidad de servicios de salud de alta complejidad en Bogotá – Colombia
dc.typeOtro
dc.rights.spaAcceso abierto
dc.type.driverinfo:eu-repo/semantics/other
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Medicina - Especialidad en Neurocirugía
dc.description.degreelevelEspecialidades Médicas
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.proposalKi67
dc.subject.proposalReceptor de progesterona
dc.subject.proposalProgesterone receptor
dc.subject.proposalMeningioma
dc.subject.proposalMeningioma
dc.subject.proposalKi67
dc.type.coarhttp://purl.org/coar/resource_type/c_1843
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2


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Atribución-NoComercial-SinDerivadas 4.0 InternacionalThis work is licensed under a Creative Commons Reconocimiento-NoComercial 4.0.This document has been deposited by the author (s) under the following certificate of deposit