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Open-Source Label-Free Microscopy

dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional
dc.contributor.advisorGarcia Sucerquia, Jorge Iván
dc.contributor.authorBuitrago Duque, Carlos Andrés
dc.date.accessioned2025-04-22T22:25:03Z
dc.date.available2025-04-22T22:25:03Z
dc.date.issued2024-10
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/88076
dc.descriptionIlustraciones, fotografías
dc.description.abstractThe rapid innovation in modern microscopy has outpaced its commercialization and adoption, leaving many users unable to access these advances. Even within the scientific community, adopting complex peer-reported designs can be challenging. To bridge the gap between microscopy innovation and widespread implementation, efforts are needed to democratize the field, making custom, research-grade instruments easily accessible to all. In this thesis, the development of open-source tools to perform label-free analysis in current science and engineering applications through digital holographic microscopy (DHM) systems, and its related technologies, was sought. To achieve it, simulation platforms, which account for the main parameters in an experimental setup, and numerical reconstruction tools that allow the digital processing of label-free recordings, were initially developed and openly distributed. Supported by these tools, accessible instrumentation of DHM systems was pursued, allowing the design and assembly of systems with increased portability and reduced cost and complexity. The developed devices and systems were validated in real-world applications, gathering valuable feedback that highlighted improvement opportunities. Finally, these opportunities were harnessed in the refinement of the proposed systems, both the software and hardware tools, enhancing their functionality. The results were reported on 13 manuscripts submitted to indexed journals of international circulation and shared in 17 presentations in international conferences. These works, which constitute the core of the present thesis, represent significant progress towards accessible, high-performance DHM and DLHM systems, with broad potential applications in both scientific research and education. (Tomado de la fuente)
dc.description.abstractLa rápida innovación en microscopía moderna ha superado su comercialización y adopción, dejando a muchos usuarios sin acceso a estos avances. Incluso dentro de la comunidad científica, la incorporación de diseños complejos reportados en la literatura es un desafío. Para cerrar la brecha entre la innovación en microscopía y su implementación generalizada, es necesario democratizar esta área de investigación, facilitando el acceso a instrumentos personalizados de nivel investigativo. En esta tesis se desarrollaron herramientas libres para realizar análisis sin marcadores en aplicaciones actuales de ciencia e ingeniería, mediante sistemas de microscopía holográfica digital (DHM) y tecnologías afines. Para ello, se desarrollaron y distribuyeron plataformas de simulación que incorporan los principales parámetros de un entorno experimental, y herramientas de reconstrucción numérica para el procesamiento digital de registros sin marcadores. Estas herramientas apoyaron el desarrollo de instrumentación accesible para sistemas DHM, permitiendo la creación de dispositivos más portátiles, económicos y de menor complejidad. Los sistemas desarrollados fueron validados en aplicaciones reales, recopilando retroalimentaciones y oportunidades de mejora, que luego fueron aprovechadas para optimizar tanto las herramientas de software como los dispositivos de hardware, mejorando su funcionalidad. Los resultados se reportaron en 13 manuscritos sometidos a revistas indexadas de circulación internacional y 17 presentaciones en conferencias internacionales. Estos trabajos, que constituyen el núcleo de esta tesis, representan un avance significativo hacia sistemas DHM y DLHM accesibles y de alto desempeño, con aplicaciones en investigación y docencia.
dc.format.extent98 páginas
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherUniversidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subject.ddc530 - Física::535 - Luz y radiación relacionada
dc.subject.ddc620 - Ingeniería y operaciones afines::621 - Física aplicada
dc.titleOpen-Source Label-Free Microscopy
dc.typeTrabajo de grado - Doctorado
dc.type.driverinfo:eu-repo/semantics/doctoralThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programMedellín - Ciencias - Doctorado en Ciencias - Física
dc.contributor.researchgroupOptica y Procesamiento Opto-Digital
dc.description.degreelevelDoctorado
dc.description.degreenameDoctor en Ciencias - Física
dc.description.researchareaMicroscopía Holográfica Digital
dc.identifier.instnameUniversidad Nacional de Colombia
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourlhttps://repositorio.unal.edu.co/
dc.publisher.facultyFacultad de Ciencias
dc.publisher.placeMedellín, Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Medellín
dc.relation.indexedLaReferencia
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.lembMicroscopía
dc.subject.lembHolografía
dc.subject.lembMicroscopía digital
dc.subject.lembNanotecnología
dc.subject.proposalDigital Holographic Microscopy
dc.subject.proposalOpen Microscopy
dc.subject.proposalLabel-Free Imaging
dc.subject.proposalQuantitative Phase Imaging
dc.subject.proposalOpen Science
dc.subject.proposalMicroscopía Holográfica Digital
dc.subject.proposalCiencia Abierta
dc.subject.proposalMicroscopía Abierta
dc.subject.proposalImágenes sin marcadores
dc.subject.proposalImágenes Cuantitativas de Fase
dc.title.translatedMicroscopía Abierta sin Marcadores
dc.type.coarhttp://purl.org/coar/resource_type/c_db06
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.redcolhttp://purl.org/redcol/resource_type/TD
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2
dcterms.audience.professionaldevelopmentEstudiantes
dcterms.audience.professionaldevelopmentInvestigadores
dcterms.audience.professionaldevelopmentMaestros
dc.description.curricularareaFísica.Sede Medellín
dc.contributor.orcidBuitrago Duque, Carlos Andrés [0000-0001-7523-9735]
dc.contributor.cvlac0000127437
dc.contributor.scopus56051519100
dc.contributor.researchgateCarlos-Buitrago-Duque
dc.contributor.googlescholarnCo6tr0AAAAJ


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