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Investigación de estrategias basadas en la actividad de agua para la estabilización de ácido ascórbico en solución acuosa

dc.rights.licenseReconocimiento 4.0 Internacional
dc.contributor.advisorMora Huertas, Claudia Elizabeth
dc.contributor.authorQuevedo Salazar, Valentina
dc.date.accessioned2025-04-25T13:17:24Z
dc.date.available2025-04-25T13:17:24Z
dc.date.issued2024
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/88119
dc.descriptionilustraciones, diagramas
dc.description.abstractLa actividad de agua ha sido ampliamente utilizada en las industrias farmacéutica y cosmética para disminuir el riesgo de contaminación microbiológica de sus productos; sin embargo, son pocas sus aplicaciones en el control de la degradación química de los ingredientes activos. Como una contribución en este sentido, la presente investigación explora el uso de diferentes categorías funcionales de excipientes como estrategias para disminuir la degradación oxidativa del ácido ascórbico, una vitamina valorada por sus propiedades antioxidantes. Con este propósito, soluciones acuosas de sales (NaCl y CaCl 2), viscosantes (hipromelosa y goma xantana), edulcorantes (sacarosa y sorbitol) y cosolventes (glicerina y polietilenglicol 200) son caracterizadas respecto a su comportamiento de actividad de agua. NaCl, sorbitol y glicerina son los excipientes que permiten cambios importantes de la actividad de agua en función de su concentración y por ello son investigados como alternativas para favorecer la estabilidad del ácido ascórbico. Como resultado, es claro que NaCl y glicerina presentan desempeños prometedores que pueden ser de interés para el desarrollo racional de medicamentos y cosméticos. (Texto tomado de la fuente).
dc.description.abstractWater activity has been widely used in the pharmaceutical and cosmetic industries to reduce the risk of microbial contamination of their products; nonetheless, applications for controlling the chemical degradation of active molecules are scarce. As a contribution to this respect, this research work investigates how excipients with different functionalities could reduce the oxidative degradation of ascorbic acid, a vitamin valued because of its antioxidant properties. To this end, aqueous solutions of salts (NaCl and CaCl 2 ), viscosity-increasing agents (hypromellose and xanthan gum), sweetening agents (sucrose and sorbitol), and solvents (glycerol and polyethylene glycol 200) are characterized regarding their water activity behaviors. NaCl, sorbitol, and glycerol allow drastic changes in water activity as a function of their concentration. Therefore, they are investigated as alternatives to favor the stability of the ascorbic acid. NaCl and glycerol show promising performances that can greatly interest the rational development of drug products and cosmetics.
dc.format.extentxiv, 74 páginas
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.publisherUniversidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.ddc610 - Medicina y salud::615 - Farmacología y terapéutica
dc.titleInvestigación de estrategias basadas en la actividad de agua para la estabilización de ácido ascórbico en solución acuosa
dc.typeTrabajo de grado - Maestría
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Ciencias - Maestría en Ciencias Farmacéuticas
dc.contributor.researchgroupDesarrollo y Calidad de Productos Farmacéuticos y Cosméticos
dc.description.degreelevelMaestría
dc.description.degreenameMagíster en Ciencias Farmacéuticas
dc.description.researchareaFarmacotecnia
dc.identifier.instnameUniversidad Nacional de Colombia
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourlhttps://repositorio.unal.edu.co/
dc.publisher.facultyFacultad de Ciencias
dc.publisher.placeBogotá, Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
dc.relation.indexedBireme
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.decsÁcido Ascórbico/farmacología
dc.subject.decsAscorbic Acid/pharmacology
dc.subject.decsExcipientes
dc.subject.decsExcipients
dc.subject.proposalActividad de agua (aw)
dc.subject.proposalExcipientes
dc.subject.proposalÁcido ascórbico
dc.subject.proposalOxidación
dc.subject.proposalEstabilidad química
dc.subject.proposalWater activity
dc.subject.proposalExcipients
dc.subject.proposalAscorbic acid
dc.subject.proposalOxidation
dc.subject.proposalChemical stability
dc.title.translatedResearch on water activity-based strategies for the stabilization of ascorbic acid in aqueous solution
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2
dcterms.audience.professionaldevelopmentEstudiantes
dcterms.audience.professionaldevelopmentInvestigadores
dcterms.audience.professionaldevelopmentMaestros
dc.subject.wikidatadisolución acuosa
dc.subject.wikidataaqueous solution


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