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Desarrollo de nanopartículas híbridas polímero – lípido con potencial aplicación en el tratamiento de la dermatitis alérgica de contacto

dc.rights.licenseAtribución-NoComercial 4.0 Internacional
dc.contributor.advisorMora Huertas, Claudia Elizabeth
dc.contributor.authorMartínez Muñoz, Oscar Iván
dc.date.accessioned2025-04-29T13:03:10Z
dc.date.available2025-04-29T13:03:10Z
dc.date.issued2024
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/88134
dc.descriptionilustraciones, diagramas
dc.description.abstractLas nanopartículas híbridas polímero – lípido (HPLNP) son sistemas transportadores de sustancias activas que han demostrado resultados prometedores en el ámbito farmacéutico gracias a su tamaño y composición. Como un aporte a la investigación en este campo la presente investigación aborda dos estrategias para la preparación de HPLNP empleando la técnica de nanoprecipitación, en las que se incorpora furoato de mometasona, un corticosteroide útil para el tratamiento de patologías cutáneas como la dermatitis alérgica de contacto. La primera estrategia para la preparación de las HPLNP es a partir de un polímero y un lípido; en la segunda estrategia, se trabaja con un polímero y un fosfolípido modificado. En los dos casos se obtienen partículas con tamaños entre 150 y 250 nm, PDI menores a 0.2, potenciales Z entre -10 y - 40 mV y eficiencias de encapsulación superiores al 95 %. La liberación del activo ocurre a los 15 min en un medio adicionado de un agente solubilizante y las dispersiones acuosas mantienen su estabilidad física durante 60 días de almacenamiento en condiciones de envejecimiento natural y 30 días en envejecimiento acelerado según las condiciones para la zona IVb estipuladas por la OMS. Los sistemas nanoparticulados se caracterizan por FTIR, DSC, XRD y TEM observándose que las HPLNP presentan una estructura predominantemente amorfa sin que se detecten incompatibilidades físicas o químicas relevantes. En conjunto, los resultados de esta investigación constituyen la fase preliminar para el desarrollo de nanopartículas que aporten valor agregado a los productos de administración tópica actualmente disponibles en el mercado a base de furoato de mometasona para los que se han evidenciado dificultades en la adherencia a la terapia debido a la necesidad de reaplicaciones y a la generación de eventos adversos (Texto tomado de la fuente).
dc.description.abstractHybrid polymer-lipid nanoparticles (HPLNP) are promising drug carriers due to their size and composition. As a contribution in this field, this work addresses two strategies to prepare this kind of particles using the nanoprecipitation technique, wherein mometasone furoate is incorporated. This is a corticosteroid useful to treat skin pathologies such as allergic contact dermatitis. The first strategy to preparing HPLNP is by using a polymer and a lipid; in the second one, a polymer and a modified phospholipid are employed. In both cases, particles with sizes ranging between 150 and 250 nm, PDI less than 0.2, Z potentials between -10 and - 40 mV, and encapsulation efficiencies greater than 95 % are obtained. The release of the active ingredient occurs after 15 min in an aqueous medium added with a solubilizing agent. The nanoparticle dispersions keep stable for 60 days of storage under natural aging conditions and 30 days under accelerated aging. The nanoparticulate systems are characterized by FTIR, DSC, XRD and TEM. Overall, the obtained results are a preliminary phase to the develop nanoparticles providing added value to the topical products currently available on the market based on mometasone furoate, which evidence difficulties in the therapy adherence because of re-application is needed and adverse events are generated.
dc.description.sponsorship“Investigación Desarrollo, innovación y transferencia de conocimiento para el procesamiento de la semilla de Sacha Inchi en productos de valor agregado, como estrategia para mejorar la productividad del sector agroindustrial de la Región Cundinamarca”. BPIN 2020000100169. Regalías. Código Hermes: 45756"
dc.format.extentxxiv, 230 páginas
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.publisherUniversidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.ddc540 - Química y ciencias afines
dc.subject.ddc620 - Ingeniería y operaciones afines
dc.subject.ddc610 - Medicina y salud::616 - Enfermedades
dc.subject.ddc610 - Medicina y salud::615 - Farmacología y terapéutica
dc.titleDesarrollo de nanopartículas híbridas polímero – lípido con potencial aplicación en el tratamiento de la dermatitis alérgica de contacto
dc.typeTrabajo de grado - Maestría
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Ciencias - Maestría en Ciencias Farmacéuticas
dc.description.degreelevelMaestría
dc.description.degreenameMagíster en Ciencias Farmacéuticas
dc.description.researchareaFarmacotecnia
dc.identifier.instnameUniversidad Nacional de Colombia
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourlhttps://repositorio.unal.edu.co/
dc.publisher.facultyFacultad de Ciencias
dc.publisher.placeBogotá, Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.lembNANOPARTICULAS
dc.subject.lembNanoparticles
dc.subject.lembMEZCLA (INGENIERIA QUIMICA)
dc.subject.lembMixing
dc.subject.lembENFERMEDADES DE LA PIEL
dc.subject.lembSkin diseases
dc.subject.lembDERMATITIS POR CONTACTO
dc.subject.lembContact dermatitis
dc.subject.lembALERGIA
dc.subject.lembAllergy
dc.subject.lembPOLIMEROS CONDUCTORES
dc.subject.lembConducting Polymers
dc.subject.lembLIPIDOS
dc.subject.lembLipids
dc.subject.proposalNanopartículas híbridas polímero – lípido
dc.subject.proposalNanoprecipitación
dc.subject.proposalDermatitis alérgica de contacto
dc.subject.proposalFuroato de mometasona
dc.subject.proposalPolymer–lipid hybrid nanoparticles
dc.subject.proposalNanoprecipitation
dc.subject.proposalAllergic contact dermatitis
dc.subject.proposalMometasone furoate
dc.title.translatedDevelopment of hybrid polymer-lipid nanoparticles with application in the treatment of allergic contact dermatitis
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentDataPaper
dc.type.contentText
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2
dcterms.audience.professionaldevelopmentPúblico general


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