Caracterización de las Estrategias de Aprendizaje de una Tarea Espacial en el Laberinto Circular de Barnes
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Amaya Durán, Laura Elena
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La navegación, aprendizaje y memoria espacial son componentes de la memoria que han sido ampliamente estudiados en animales, ya que la comprensión de los mecanismos biológicos y sistemas de memoria subyacentes puede llevar a explicaciones integrales y al desarrollo de tratamientos de déficits mnésicos en humanos. En el presente estudio se buscó describir y modelar de manera robusta, mediante la utilización del software BUNS (Barnes maze Unbiased Strategy Classification) (Illouz, et. al., 2016) los tipos de estrategia de navegación y aprendizaje de una tarea espacial que despliegan 50 ratas Wistar machos, entrenadas durante 16 ensayos en el Laberinto circular de Barnes. Se encontró que para este tipo de protocolo de entrenamiento, se utilizan estrategias predominantemente espaciales. Se halló también que la eficiencia en el aprendizaje de esta tarea implica la identificación de una ubicación cercana a la meta, como lo demuestra el despliegue de estrategias corregidas.
Abstract: Spatial navigation, learning and memory are different but complementary components of memory that have been widely studied in animals. Understanding the biological mechanisms and memory systems that underlie these components may result in a better understanding and development of treatments for humans suffering from mnesic deficits. This study seeked the description and robust modeling, using the BUNS (Barnes maze Unbiased Strategy Classification) software (Illouz, et. al., 2016) of the types of learning strategy used by 50 Wistar male rats, when trained in the Barnes circular maze over 16 trials. It was found that, for this particular protocol of training, the strategies predominantly displayed by the subjects were spatial strategies. Apparently, the efficiency in learning this task involves the identification of a nearby to the scape goal location, rather than a specific one, as showed by the use of Corrected strategies over direct ones.
Abstract: Spatial navigation, learning and memory are different but complementary components of memory that have been widely studied in animals. Understanding the biological mechanisms and memory systems that underlie these components may result in a better understanding and development of treatments for humans suffering from mnesic deficits. This study seeked the description and robust modeling, using the BUNS (Barnes maze Unbiased Strategy Classification) software (Illouz, et. al., 2016) of the types of learning strategy used by 50 Wistar male rats, when trained in the Barnes circular maze over 16 trials. It was found that, for this particular protocol of training, the strategies predominantly displayed by the subjects were spatial strategies. Apparently, the efficiency in learning this task involves the identification of a nearby to the scape goal location, rather than a specific one, as showed by the use of Corrected strategies over direct ones.