Reacciones de reducción, oxidación y conjugación del aflatoxicol y la aflatoxina B1 in vitro a partir de extractos de hígado provenientes de cuatro especies de aves de importancia comercial

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dc.contributor.advisorDiaz, Gonzálospa
dc.contributor.authorMurcia Gutiérrez, Hansen Wilberspa
dc.contributor.researchgroupGrupo de Investigación en Toxicología y Nutrición Aviarspa
dc.date.accessioned2020-10-05T15:20:24Zspa
dc.date.available2020-10-05T15:20:24Zspa
dc.date.issued2020-09-09spa
dc.description.abstractEnzymatic parameters of in vitro metabolism of aflatoxin B1 (AFB1) in chicken, quail, turkey and duck are related to resistance to AFB1 toxic effects. Duck, a highly sensitive species, produce the higher ammount of AFB1-8,9-epoxide (AFBO) and AFB1 dihydrodiol (AFB1-dhd). AFBO is the bioactivated genotoxic form of AFB1 and can adduct guanine nucleotides in DNA. Spontaneous hydrolisis of AFBO produces AFB1, which in turns rearranges in a pH dependent manner to AFB1 dialdehyde. AFB1 dialdehyde adducts lysine in proteins and therefore leads to cytotoxicity. Enzymatic reduction of AFB1 dialdehyde occurs through aflatoxin B1 aldehyde reductase (AFAR) enzyme and products of this enzyme activity are AFB1 monoalcohol and AFB1 dialcohol (detoxifying products). It was observed that turkey (intermediate sensitive) and chicken (resistant species) possess the highest AFAR activity. In regards of aflatoxicol (reduced form of AFB1) production, it is related to more resistance species like chicken, quail, and turkey, as way to avoid AFB1 epoxidation, meaning that AFBO is produced at lower rates. In silico simulation demonstrated that duck species produce the higher amount of guanine and lysine adducts, in contrast to the other poultry species studied. This fact explains why duck is the only species that develop hepatocarcinoma and severe adverse effects. Apparently, AFB1 dialdehyde is eliminated as AFB1 dialcohol.spa
dc.description.abstractLos parámetros enzimáticos del metabolismo de la aflatoxina B1 (AFB1) en aves de producción como el pollo, la codorniz, el pavo y el pato se encuentran relacionados con la tolerancia los efectos tóxicos de esta micotoxina. El pato (especie sensible) produce la mayor cantidad de AFB1-8,9-epó xido (AFBO) y AFB1 dihidrodiol (AFB1-dhd). El AFBO es la forma bioactiva genotóxica de la AFB1, ya que genera aductos con guanina. La hidrólisis espontánea del AFBO produce AFB1-dhd, el cual de manera dependiente del pH sufre un rearreglo a AFB1 dialdehído. El dialdehído genera aductos con la lisina de las proteínas y por consiguiente, citotoxicidad. La reducción del dialdeh´ıdo ocurre por medio de la enzima enzima aflatoxina B1 aldeh´ıdo reductasa (AFAR), la cual produce AFB1 monoalcohol y AFB1 dialcohol (productos de detoxificación). Se observó que el pavo (sensibilidad intermedio) y el pollo (resistente) tienen la mayor actividad AFAR. La producción de aflatoxicol (forma reducida de la AFB1) permite a especies más resistentes como el pollo, la codorniz y el pavo evitar la epoxidación de la AFB1, es decir, la producción de AFBO. La simulación in silico demostró que el pato es el que más produce aductos con guanina y lisina, a diferencia de las otras especies, lo cual explica por que el pato es la ´unico especie que desarrolla hepatocinoma, además de signos severos. Al parecer, la AFB1 dialdehído es eliminada como dialcohol.spa
dc.description.additionalLínea de Investigación: Metabolismo hepático in vitro de xenobióticosspa
dc.description.degreelevelDoctoradospa
dc.description.projectDoctorados Nacionales Convocatoria 647spa
dc.description.sponsorshipColcienciasspa
dc.format.extent138spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.citationMurcia, H.W.: Reacciones de reducción, oxidación y conjugación del aflatoxicol y la aflatoxina B1 in vitro a partir de extractos de hígado provenientes de cuatro especies de aves de importancia comercial. Tesis de Doctorado. Instituto de Biotecnología. Universidad Nacional de Colombia Sede Bogotá. 2020.spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/78523
dc.language.isospaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.programBogotá - Ciencias - Doctorado en Biotecnologíaspa
dc.relationMurcia, H.W., Diaz, G.J. 2020. Dealing with aflatoxin B1 dihydrodiol acute effects: Impact of aflatoxin B1-aldehyde reductase enzyme activity in poultry species tolerance to AFB1 toxic effects. PLoS One 15: e0235061. ISSN: 1932-6203. Publicado 22 junio 2020. San Francisco, USA. https://doi.org/10.1371/journal.pone.0235061.spa
dc.relationMurcia, H.W., Diaz, G.J. 2020. In vitro hepatic aflatoxicol production is related to a higher resistance to aflatoxin B1 in poultry. Scientific Reports 10: 5508. ISSN: 2045-2322. Publicado: 26 marzo 2020. Londres, Reino Unido. https://doi.org/10.1038/s41598-020-62415-yspa
dc.relationDiaz, G.J., Murcia, H.W. 2019. An unusually high production of hepatic aflatoxin B1-dihydrodiol, the possible explanation for the high susceptibility of ducks to aflatoxin B1. Scientific Reports 9: 8010. ISSN: 2045-2322. Publicado: 29 mayo 2019. Londres, Reino Unido. https://doi.org/10.1016/0003-2697(86)90091-6spa
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dc.rightsDerechos reservados - Universidad Nacional de Colombiaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial 4.0 Internacionalspa
dc.rights.spaAcceso abiertospa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/spa
dc.subject.ddc500 - Ciencias naturales y matemáticasspa
dc.subject.proposalAflatoxina B1spa
dc.subject.proposalAflatoxin B1eng
dc.subject.proposalAflatoxina B1 dialdehídospa
dc.subject.proposalAFB1-Gua adducteng
dc.subject.proposalAflatoxicolspa
dc.subject.proposalAFB1-Lys adducteng
dc.subject.proposalAflatoxicoleng
dc.subject.proposalAflatoxina B1 dihidrodiolspa
dc.subject.proposalAflatoxin epoxideeng
dc.subject.proposalAflatoxina B1 monoalcoholspa
dc.subject.proposalAflatoxin B1 dihydrodioleng
dc.subject.proposalAflatoxina B1 dialcoholspa
dc.subject.proposalAducto AFB1-Guaspa
dc.subject.proposalAflatoxin B1 dialdehydeeng
dc.subject.proposalAflatoxin B1 monoalcoholeng
dc.subject.proposalAducto AFB1-Lysspa
dc.subject.proposalAflatoxina B1 epóxidospa
dc.subject.proposalAflatoxin B1 dialcoholeng
dc.titleReacciones de reducción, oxidación y conjugación del aflatoxicol y la aflatoxina B1 in vitro a partir de extractos de hígado provenientes de cuatro especies de aves de importancia comercialspa
dc.typeTrabajo de grado - Doctoradospa
dc.type.coarhttp://purl.org/coar/resource_type/c_db06spa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/doctoralThesisspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

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Doctorado en Biotecnología