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Evaluación de la reproducibilidad y precisión para diferentes técnicas de cuantificación en Medicina Nuclear
dc.rights.license | Atribución-NoComercial 4.0 Internacional |
dc.contributor.advisor | Plazas de Pinzón, María Cristina |
dc.contributor.advisor | Barbosa Parada, Nathaly |
dc.contributor.author | Niño Duarte, Franklin |
dc.date.accessioned | 2020-06-10T16:18:05Z |
dc.date.available | 2020-06-10T16:18:05Z |
dc.date.issued | 2019-12-05 |
dc.identifier.uri | https://repositorio.unal.edu.co/handle/unal/77637 |
dc.description.abstract | La cuantificación de actividad es una labor importante dentro de las aplicaciones de la Medicina Nuclear, ya que de ésta dependen la dosimetría para la terapia con radionúclidos, la planificación de tratamiento y la efectividad del mismo. A su vez la cuantificación depende de la reproducibilidad de las técnicas y la precisión en la adquisición de la información necesaria para estos procesos. Este trabajo evalúa la reproducibilidad y precisión para la cuantificación de actividad de I-131 mediante técnicas imagenológicas y no imagenólogicas. Para cuantificar con precisión mediante las técnicas empleadas (SPECT-CT, Sonda de captación tiroidea y Geiger-Müller), se requiere la corrección de efectos degradantes asociados con procesos físicos que afectan la información recuperada, como el fondo, atenuación, dispersión, tiempo muerto, entre otros. A su vez es necesario definir una geometría de medición que permita reproducir estos procesos. Para cada técnica fue calculado un Factor de Calibración (FC) que permite convertir la información corregida en unidades de actividad. Se realizaron distintas pruebas para la estimación de los efectos de influencia y su posterior corrección para cada técnica. Se encontró que las técnicas empleadas son reproducibles para las geometrías definidas. De igual forma se determinó el FC para I-131 en cada una de estas geometrías con un adecuado grado de precisión. Para técnicas imagenológicas se encontró que el FC calculado es independiente de la técnica de adquisición, sin embargo, muestra dependencia con el volumen de la fuente. Se obtuvo para SPECT-CT un FC=(1,24 +/- 0,13) cpm/kBq, para la sonda de captación tiroidea un FC= (7,44 +/- 0,01) cpm/kBq, para los detectores Geiger-Müller un FCH1(x)= (33,75 +/- 14,22$)x^ (-2,82 +/- 1,24) uSv/h/GBq y FCH2(x)= (20,47 +/- 11,15)x^ (-2,45 +/- 1,48) uSv/h/GBq, estos últimos en función de la distancia al detector. |
dc.description.abstract | Quantification of activity is an important work within the applications of Nuclear Medicine, since dosimetry for radionuclide therapy, treatment planning and its effectiveness depend on it. In turn quantification depends on the reproducibility of the techniques and precision in acquiring the information needed for these processes. This study evaluates the reproducibility and accuracy for the quantification of activity I-131 by imaging and non-imaging techniques. To quantify accurately by the techniques used (SPECT-CT, Thyroid uptake probe and Geiger-Müller), the correction of degrading effects associated with physical processes that affect the information retrieved, such as background, attenuation, dispersion, dead time is required , among others. In turn, it is necessary to define a measurement geometry that allows reproducing these processes. For each technique a Calibration Factor (CF) was calculated, which allows the corrected information to be converted into units of activity. Different tests were performed to estimate the influence effects and their subsequent correction for each technique. It was found that the techniques used are reproducible for the defined geometries. In the same way the CF was determined for I-131 in each of these geometries with an adequate degree of precision. For imaging techniques it was found that the calculated CF is independent of the acquisition technique, however, it shows dependence on the volume of the source. A CF=(1,24 +/- 0,13) cpm/kBq was obtained for SPECT-CT, for the thyroid uptake probe a CF= (7,44 +/- 0,01) cpm/kBq, for Geiger-Müller detectors a CFH1(x)= (33,75 +/- 14,22$) x^ (-2,82 +/- 1,24) uSv/h/GBq and CFH2(x)= (20,47 +/- 11,15) x^ (-2,45 +/- 1,48) uSv/h/GBq, the latter depending on the distance to the detector. |
dc.format.extent | 108 |
dc.format.mimetype | application/pdf |
dc.language.iso | spa |
dc.rights | Derechos reservados - Universidad Nacional de Colombia |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ |
dc.title | Evaluación de la reproducibilidad y precisión para diferentes técnicas de cuantificación en Medicina Nuclear |
dc.type | Otro |
dc.rights.spa | Acceso abierto |
dc.description.additional | Magister en Física Médica |
dc.type.driver | info:eu-repo/semantics/other |
dc.type.version | info:eu-repo/semantics/acceptedVersion |
dc.publisher.program | Bogotá - Ciencias - Maestría en Física Médica |
dc.description.degreelevel | Maestría |
dc.publisher.department | Departamento de Física |
dc.publisher.branch | Universidad Nacional de Colombia - Sede Bogotá |
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dc.rights.accessrights | info:eu-repo/semantics/openAccess |
dc.subject.proposal | Activity quantification |
dc.subject.proposal | Cuantificación de actividad |
dc.subject.proposal | I-131 |
dc.subject.proposal | I-131 |
dc.subject.proposal | Precision |
dc.subject.proposal | Precisión |
dc.subject.proposal | Factor de calibración |
dc.subject.proposal | Calibration factor |
dc.subject.proposal | Imagenológicas |
dc.subject.proposal | Imaging |
dc.subject.proposal | No Imaging |
dc.subject.proposal | No imagenológicas |
dc.type.coar | http://purl.org/coar/resource_type/c_1843 |
dc.type.coarversion | http://purl.org/coar/version/c_ab4af688f83e57aa |
dc.type.content | Text |
oaire.accessrights | http://purl.org/coar/access_right/c_abf2 |
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