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Determinación de los niveles séricos de Angiopoietin Like 3 (ANGPTL3) en mujeres gestantes sanas y preeclámpticas. Un estudio longitudinal en la ciudad de Bogotá

dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.contributor.advisorGarcés, María Fernanda
dc.contributor.advisorMaldonado Acosta, Luis Miguel
dc.contributor.advisorCaminos, Jorge
dc.contributor.authorCastro Pinzón, Andrés
dc.date.accessioned2021-01-25T17:08:25Z
dc.date.available2021-01-25T17:08:25Z
dc.date.issued2020-01-15
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/78905
dc.description.abstractIntroduction: ANGPTL-3 is a protein that regulates the activity of LPL and could have an important role in in lipid metabolism during pregnancy. Methods: This is a prospective cohort study aiming to measure serum Angiopoietin-Like 3 (ANGPTL3) levels in healthy and preeclamptic women during three periods of gestation and three months postpartum and to correlate them with biochemical, hormonal and anthropometric indices. This includes a group of healthy pregnant women (n = 52), followed for three periods of gestation: early, intermediate, late and 19 of these women were analyzed three months postpartum. Additionally, data of 21 pregnant women belonging to the same cohort who developed mild preeclampsia were selected and analyzed. Results: ANGPTL-3 levels in non-pregnant women were higher than women in the first trimester of healthy pregnancy (119.28 ng / mL vs 72.78 ng / mL, P <0.05). During healthy pregnancy, a statistically significant decrease in serum ANGPTL-3 was observed in the first trimester, with no significant change in the second trimester and with a statistically significant increase in the third trimester, but still lower than the ANGPTL-3 levels of non-pregnant patients, which returns to their baseline values after delivery. No significant differences were found in ANGPTL-3 levels between healthy pregnant women and pregnant women with mild pre-eclampsia in any of the trimesters. There was no consistent correlation of ANGPLT-3 with triglyceride levels in the groups of pregnant women, and there was a correlation of LDL-C levels throughout gestation with mild pre-eclampsia (P <0.05). Conclusion: The decrease in ANGPTL-3 levels, probably mediated by insulin sensitivity, frees LPL from the inhibition of ANGPTL-3 and it can be regulated by other hormones, placental and non-placental, in order to organize the gestation energy metabolism in its different phases.
dc.description.abstractIntroducción: La ANGPTL-3 es una proteína que regula negativamente la actividad de la LPL, por lo podría tener un rol importante en el metabolismo lipídico durante la gestación. Métodos: El presente es un estudio de cohorte prospectivo con el objetivo de determinar los niveles séricos Angiopoietin-Like 3 (ANGPTL3) en mujeres sanas y preeclámpticas durante tres periodos de la gestación y tres meses postparto y correlacionarlos con variables bioquímicas, hormonales e índices antropométricos. Este incluye un grupo de mujeres gestantes sanas (n=52), seguidas durante tres periodos de la gestación: temprano, intermedio, tardío y 19 de estas mujeres fueron analizadas tres meses postparto. Adicionalmente, se seleccionaron 21 gestantes pertenecientes a la misma cohorte que desarrollaron preeclampsia leve. Resultados: Los niveles de ANGPTL-3 de las mujeres no gestantes fueron mayores que en el primer trimestre de la gestación sana (119.28 ng/mL vs 72.78 ng/mL, P < 0.05). Durante la gestación sana se observa una disminución estadísticamente significativa de la ANGPTL-3 en el primer trimestre, sin cambio significativo en el segundo trimestre y con un aumento estadísticamente significativo en el tercer trimestre pero que siguen siendo menores que los niveles de ANGPTL-3 de las pacientes no gestantes, que vuelve a sus valores basales después del parto. No se encontraron diferencias significativas en niveles de ANGPTL-3 entre las gestantes sanas y las gestantes con preeclampsia leve en ninguno de los trimestres de la gestación. No se encontró correlación consistente de ANGPLT-3 con los niveles de triglicéridos en los grupos de gestantes y hubo correlación de los niveles de c-LDL a lo largo de la gestación con preeclampsia leve (P<0.05). Conclusión: La caída de los niveles de ANGPTL-3 mediada probablemente por la sensibilidad a la insulina libera a la LPL de la inhibición de la ANGPTL-3 para poder ser regulada por otras hormonas, placentarias y no placentarias, con el fin de organizar el metabolismo energético de la gestación en sus diferentes fases
dc.format.extent105
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.rightsDerechos reservados - Universidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleDeterminación de los niveles séricos de Angiopoietin Like 3 (ANGPTL3) en mujeres gestantes sanas y preeclámpticas. Un estudio longitudinal en la ciudad de Bogotá
dc.typeOtro
dc.rights.spaAcceso abierto
dc.type.driverinfo:eu-repo/semantics/other
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Medicina - Especialidad en Endocrinología
dc.description.degreelevelEspecialidades Médicas
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.proposalAngiopoietin-Like 3
dc.subject.proposalAngiopoietin-Like 3
dc.subject.proposalANGPTL-3 in pregnancy
dc.subject.proposalANGPTL-3 en gestación
dc.subject.proposalLipid metabolism in pregnant women
dc.subject.proposalMetabolismo lipídico en gestantes
dc.subject.proposalLipoprotein lipase and pregnancy
dc.subject.proposalLipoproteinlipasa y gestación
dc.type.coarhttp://purl.org/coar/resource_type/c_1843
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2


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