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Simulation of chemotactic migration of a crawling cell by finite elements in a two-dimensional framework

dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.contributor.advisorGarzón Alvarado, Diego Alexánder
dc.contributor.advisorMadzvamuse, Anotida
dc.contributor.authorHernández Aristizábal, David
dc.date.accessioned2021-05-20T17:59:51Z
dc.date.available2021-05-20T17:59:51Z
dc.date.issued2021
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/79543
dc.descriptionilustraciones a color, tablas
dc.description.abstractLa migración celular es un proceso presente en todas las etapas de la vida que es accionado principalmente por la dinámica del citoesqueleto de actina. Los trabajos experimentales y computacionales han sido clave para elucidar los mecanismos presentes en este fenómeno. Los primeros permiten modelar interacciones intra y extracelulares de forma realística y los segundos permiten aislar y analizar tales interacciones. En este trabajo se presenta un marco computacional capaz de copiar algunas características de la migración celular en dos dimensiones. Se consideran dinámicas membranales y citosólicas que pueden ser activadas o modificadas por señales externas. Los resultados muestran que la implementación computacional es capaz de reproducir las siguientes características fundamentales: (i) polarización en la membrana, (ii) polarización en el citosol y (iii) protusiones dependientes de actina.
dc.description.abstractCell migration is a process ubiquitous in life that is mainly trigger by the dynamics of the actin cytoskeleton. Experimental and computational works have been key to elucidate the mechanisms underlying this phenomenon. The former allow modelling realistic interactions both at the intra and extracellular level while the later allow the isolation and analysis of such interactions. Here, we present a computational framework able to mimic some two-dimensional cell-migration features considering membrane and cytosolic activities that may be triggered by external cues. The results show that the computational implementation is able to deal with the following fundamental characteristics: (i) membrane polarisation, (ii) cytosolic polarisation, and (iii) actin-dependent protrusions.
dc.format.extent1 recurso en línea (77 páginas)
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherUniversidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/
dc.subject.ddc620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
dc.subject.otherSimulación (Informática)
dc.subject.otherComputer simulation
dc.titleSimulation of chemotactic migration of a crawling cell by finite elements in a two-dimensional framework
dc.typeTrabajo de grado - Maestría
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Ingeniería - Maestría en Ingeniería - Ingeniería Mecánica
dc.contributor.researchgroupGNUM - Grupo de Modelado y Métodos Numericos en Ingeniería
dc.description.degreelevelMaestría
dc.description.degreenameMagíster en Ingeniería - Ingeniería Mecánica
dc.description.researchareaModelación computacional
dc.identifier.instnameUniversidad Nacional de Colombia
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourlhttps://repositorio.unal.edu.co/
dc.publisher.facultyFacultad de Ingeniería
dc.publisher.placeBogotá
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.decsQuimiotaxis
dc.subject.decsChemotaxis
dc.subject.decsCélulas Quimiorreceptoras
dc.subject.decsChemoreceptor Cells
dc.subject.proposalcomputational cell migration
dc.subject.proposalESFEM
dc.subject.proposalMoving mesh
dc.subject.proposalbulk-surface PDE
dc.subject.proposalMigración celular computacional
dc.subject.proposalMétodo de elementos finitos en superficies en evolución
dc.subject.proposalMalla en movimiento
dc.subject.proposalEDP de bulto y superficie
dc.title.translatedSimulación del movimiento tipo arrastrado de una célula en migración tipo quimiotáctica por elementos finitos en un dominio bidimensional
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dc.type.redcolhttp://purl.org/redcol/resource_type/TM
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