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Efecto del trasplante autólogo de células de la glia envolvente olfatoria en casos clínicos de lesión medular en caninos

dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.contributor.advisorBotero Espinosa, Lucía
dc.contributor.advisorGhome Ghotme, Kemel
dc.contributor.authorOtálora Otálora, Juan Martín
dc.contributor.otherGhotme Ghotme, Kemel
dc.date.accessioned2021-08-25T19:58:32Z
dc.date.available2021-08-25T19:58:32Z
dc.date.issued2021
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/80016
dc.descriptiongráficas, ilustraciones, tablas
dc.description.abstractSpinal cord injury is an unfortunate event that generally involves a condition that in the short, medium and long term has multiple implications not only for the person suffering from it but also for their family nucleus and society in general (DeVivo and Chen, 2011; Angeli et al., 2018). For its treatment with cell therapy, a variety of cells have been used, among which the transplantation of ensheathing glial cells (CGEO). Specifically in canines, CGEO of the olfactory bulb and olfactory mucosa have been used, obtained through moderately invasive surgical procedures. In this research we innovate in taking the sample endoscopically in the nasal cavity avoiding the surgical approach to the nasal sinus and we also innovate by performing the transplant with a percutaneous technique with ultrasound guidance for the introduction of the needle and the deposit of cells intramedullary level without the need for an invasive surgical procedure involving laminectomy or myelotomy. We use magnetic resonance imaging to identify the exact site of the injury to perform the transplant. We measured the effect of non-purified CGEO transplantation (containing an average of 45% CGEO) in a sample of 8 companion dogs that presented chronic traumatic spinal cord injury in the city of Bogotá. Neurological tests and gait evaluation were performed using the Olby scale in pre-transplantation and monthly post-transplantation for three months, finding significant changes in some of the variables analyzed. Therefore, we were able to conclude that the effect of CGEO transplantation in clinical cases of spinal cord injury in canines is safe and brought beneficial effects in some of the patients. It is worth clarifying that there were no recoveries in the general proprioception tests or in postural reactions, so we think that the observed improvements were possibly due to local changes in spinal circuits and not to a recovery of movement that depends on long ascending and long tracts descending.
dc.description.abstractLa lesión medular es un infortunado evento que generalmente implica un padecimiento que a corto, mediano y largo plazo tiene múltiples implicaciones no solo para quien la padece sino además para su núcleo familiar y la sociedad en general (DeVivo and Chen, 2011; Angeli et al., 2018). Para su tratamiento con terapia celular se han utilizado variedad de células entre las que se destacan el trasplante de células de la glía envolvente olfatoria (CGEO). Específicamente en caninos se han utilizado CGEO del bulbo olfatorio y de la mucosa olfatoria, obtenidas mediante procedimientos quirúrgicos medianamente invasivos. En esta investigación innovamos en la toma de la muestra por vía endoscópica en la cavidad nasal evitando el abordaje quirúrgico del seno nasal e innovamos también al realizar el trasplante con una técnica percutánea con guía ecográfica para la introducción de la aguja y el depósito de las células a nivel intramedular sin necesidad de realizar un procedimiento quirúrgico invasivo que implicara laminectomía y mielotomía. Utilizamos imágenes de resonancia magnética para identificar el sitio exacto de la lesión para realizar el trasplante. Medimos el efecto del trasplante de CGEO no purificadas (conteniendo en promedio un 45% de CGEO) en una muestra de 8 perros de compañía que presentaron lesión medular traumática crónica en la ciudad de Bogotá. Se realizaron pruebas neurológicas y evaluación de la marcha utilizando la escala Olby en pre-trasplante y mensuales pos-trasplante por tres meses encontrando cambios significativos en algunas de las variables analizadas. Por lo que pudimos concluir que el efecto del trasplante de CGEO en casos clínicos de lesión medular en caninos es seguro y trajo efectos benéficos en algunos de los pacientes. Es de aclarar que no se presentaron recuperaciones en las pruebas de propiocepción general ni en reacciones posturales por lo que pensamos que las mejoras observadas se debieron posiblemente a cambios locales en circuitos medulares y no a una recuperación del movimiento que depende de tractos largos tanto ascendentes como descendentes (Texto tomado de la fuente)
dc.format.extentXXII, 132 páginas
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.publisherUniversidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddcNeurociencias
dc.titleEfecto del trasplante autólogo de células de la glia envolvente olfatoria en casos clínicos de lesión medular en caninos
dc.typeTrabajo de grado - Maestría
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Medicina - Maestría en Neurociencias
dc.description.degreelevelMaestría
dc.description.degreenameMagister en Neurociencias
dc.identifier.instnameUniversidad Nacional de Colombia
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourlhttps://repositorio.unal.edu.co/
dc.publisher.facultyFacultad de Medicina
dc.publisher.placeBogotá, Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.lembTransplantation of organs, tissues, etc
dc.subject.lembTrasplante de órganos, tejidos, etc.
dc.subject.lembTrasplante celular
dc.subject.lembCell--transplantation
dc.subject.proposalLesión medular
dc.subject.proposalSpinal cord injury
dc.subject.proposalCélulas de la glía envolvente olfactoria
dc.subject.proposalolfactory ensheathing glial cells
dc.subject.proposalTrasplante autólogo
dc.subject.proposalAutologous trasplant
dc.title.translatedEffect of autologous cell trasplantation olfactory ensheathing glial in clinical cases spinal cord injury in canines
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2


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