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Influence of the micro-geometry of a scaffold for bone regeneration on the stresses of the newly formed tissue

dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.contributor.advisorCortés Rodríguez, Carlos Julio
dc.contributor.advisorBoccaccio, Antonio
dc.contributor.authorRodríguez Montaño, Óscar Libardo
dc.date.accessioned2022-02-14T14:37:50Z
dc.date.available2022-02-14T14:37:50Z
dc.date.issued2021-12-17
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/80968
dc.descriptionilustraciones, gráficas, tablas
dc.description.abstractScaffolds for tissue engineering are porous devices that have gain an enormous attention in the last decades for multiple disciplines, as solution to help the repair process that cannot heal spontaneously by natural mechanisms. Since the in vitro and in vivo procedures test the different key factors in the design and its outcomes, in silico research brings an unbeatable tool for understanding the processes that occur within these devices and how different design variables will influence the final result of the treatment. It is well known that the biomechanical cues are relevant in the bone repair processes and those are related to the stimuli transmitted to the repair environment, as the callus in a normal healing process, or to the support structure, such as orthopedic fixation devices and/or the scaffold to help the regeneration process. Researchers in the last decades have made efforts to characterize the favorable biophysical stimuli to the formation of bone and other types of tissue. Different geometric configurations of the scaffold microstructure can transmit the loads to the newly formed tissue in different ways, depending on the topology of the microstructure, but it is not clear how this process takes place during the regeneration, and moreover, how it changes if the biophysical environment is changing, as a consequence of the scaffold degradation. However, it has been demonstrated that there are more favorable scaffold micro-geometries to the bone healing process than others. The general aim of this research was to investigate computationally, how the micro-geometry of scaffolds for bone regeneration influences the stresses on the newly formed tissue. To achieve this objective, an in silico framework based on the finite element method is used to represent the tissue evolution inside the scaffold and statistical analysis is used to determine the evolution of the stresses within the neo-formed tissue. The in silico framework is also used to find favorable parameters that define the micro-geometry of different bone tissue scaffold designs. The results obtained in this thesis enrich the understanding and discussion regarding the biophysical phenomena that occur inside the scaffold, thus allowing to identify better designs from a biomechanical perspective.
dc.description.abstractLos scaffolds para ingeniería de tejidos son dispositivos que han ganado una enorme atención en múltiples disciplinas durante las últimas décadas, como apoyo para los procesos de reparación que no ocurren de forma espontánea por medio de mecanismos naturales. Dado que los procedimientos in vitro e in vivo permiten evaluar los diferentes factores claves en el diseño de scaffolds y sus resultados, la investigación in silico brinda una herramienta excepcional para entender los procesos que ocurren dentro de estos dispositivos y cómo las diferentes variables de diseño influencian sus resultados finales. Es bien sabido que las señales biomecánicas son relevantes en los procesos de reparación ósea y éstas están relacionadas con los estímulos transmitidos al ambiente de reparación como el callo en procesos normales o a las estructuras de soporte como dispositivos ortopédicos de fijación y/o scaffolds que favorecen el proceso de regeneración. En las últimas décadas los investigadores han hecho esfuerzos por caracterizar los estímulos biofísicos favorables para la formación de hueso y otros tipos de tejidos. Diferentes configuraciones geométricas de un scaffold pueden transmitir las cargas al tejido en formación en diferentes maneras dependiendo de la topología de su microestructura, pero no es claro como es este proceso durante la regeneración, y más aún, se desconoce como el ambiente biofísico dentro del scaffold está cambiando como consecuencia de su degradación. Pese a lo anterior, ha sido demostrado que hay micro-geometrías de scaffolds más favorables que otras para la regeneración ósea. El objetivo general es investigar computacionalmente como la micro-geometría de un scaffold para regeneración ósea influencia los esfuerzos en el tejido en formación. Para lograr este objetivo, un marco computacional basado en el método de los elementos finitos es usado para representar la evolución del tejido dentro del scaffold, en conjunto con análisis estadísticos para determinar la evolución de los esfuerzos en el tejido. Dicho marco tambien es usado para encontrar parámetros favorables que definen la micro-geometría de diferentes diseños de scaffolds. Los resultados obtenidos en esta tesis enriquecen la comprensión y discusión sobre los fenómenos biofísicos que suceden dentro del scaffold, permitiendo identificar mejores diseños desde una perspectiva biomecánica. (Texto tomado de la fuente).
dc.description.sponsorshipMinisterio de Ciencia, Tecnología e Innovación MINCIENCIAS
dc.format.extentxvii, 169 páginas
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherUniversidad Nacional de Colombia
dc.rightsDerechos reservados al autor, 2021
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc620 - Ingeniería y operaciones afines
dc.titleInfluence of the micro-geometry of a scaffold for bone regeneration on the stresses of the newly formed tissue
dc.typeTrabajo de grado - Doctorado
dc.type.driverinfo:eu-repo/semantics/doctoralThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Ingeniería - Doctorado en Ingeniería - Ingeniería Mecánica y Mecatrónica
dc.description.notesIncluye anexos
dc.contributor.researchgroupGrupo de Investigación en Biomecánica / Universidad Nacional de Colombia Gibm-Uncb
dc.contributor.sponsorMINCIENCIAS
dc.description.degreelevelDoctorado
dc.description.degreenameDoctor en Ingeniería
dc.description.researchareaBiomecánica
dc.identifier.instnameUniversidad Nacional de Colombia
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourlhttps://repositorio.unal.edu.co/
dc.publisher.departmentDepartamento de Ingeniería Mecánica y Mecatrónica
dc.publisher.facultyFacultad de Ingeniería
dc.publisher.placeBogotá, Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.decsTissue Engineering
dc.subject.decsIngeniería de Tejidos
dc.subject.decsTissue Scaffolds
dc.subject.decsAndamios del Tejido
dc.subject.decsBone Regeneration
dc.subject.decsRegeneración Ósea
dc.subject.proposalScaffold
dc.subject.proposalMechanobiology
dc.subject.proposalBone
dc.subject.proposalHealing
dc.subject.proposalComputational
dc.subject.proposalModeling
dc.subject.proposalDegradation
dc.subject.proposalNewly formed tissue
dc.subject.proposalAndamio
dc.subject.proposalHueso
dc.subject.proposalModelamiento computacional
dc.subject.proposalDiferenciación
dc.subject.proposalTejido en formación
dc.subject.proposalSimulation
dc.subject.proposalSimulación
dc.title.translatedInfluencia de la micro-geometría de un scaffold para regeneración ósea en los esfuerzos en el tejido en formación
dc.type.coarhttp://purl.org/coar/resource_type/c_db06
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.redcolhttp://purl.org/redcol/resource_type/TD
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2
dcterms.audience.professionaldevelopmentInvestigadores
dcterms.audience.professionaldevelopmentPúblico general


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