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Rifaximina en enfermedad diverticular sintomática no complicada. Revisión sistemática de la literatura

dc.rights.licenseAtribución-SinDerivadas 4.0 Internacional
dc.contributor.advisorOtero Regino, William Alberto
dc.contributor.advisorEstrada Orozco, Kelly
dc.contributor.authorBastidas Riascos, Melissa del Rosario
dc.date.accessioned2022-02-16T17:11:49Z
dc.date.available2022-02-16T17:11:49Z
dc.date.issued2021
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/80996
dc.descriptionilustraciones, gráficas, tablas
dc.description.abstractRifaximina en enfermedad diverticular sintomática no complicada. Revisión sistemática de la literatura Introducción: La rifaximina es un antibiótico que inhibe la síntesis del ARN bacteriano y se ha propuesto en el tratamiento de enfermedad diverticular sintomática no complicada (EDSNC), pero hay controversia sobre su utilidad. Objetivo: Determinar la efectividad y seguridad de la rifaximina frente a otras intervenciones o no intervención en la mejoría de los síntomas de pacientes con EDSNC. Materiales y métodos: Investigamos en todas las bases de datos hasta Julio 2021 para identificar experimentos clínicos, otros estudios de intervención, cohortes o casos y controles que evaluaran la efectividad y seguridad de la rifaximina frente a otras intervenciones o no intervención en la mejoría de los síntomas de pacientes con EDSNC. La calidad metodológica de los estudios incluidos se evaluó de acuerdo al tipo de diseño. Se realizó síntesis cualitativa. Resultados: se tamizaron 1489 referencias. Se revisaron 18 referencias en texto completo, de las cuales se excluyeron siete. 11 estudios cumplieron criterios de inclusión y exclusión. En los ECA (ensayos clínicos) existió mejoría en el score global sintomático a 14+/-2 días p<0.005, 6 meses (p<0.001), 12 meses (p<0.001), 24 meses (p<0.001) con diferencias estadísticamente significativa. En el estudio cuasiexperimetal y en los estudios observacionales también existió reducción significativa a los 3 meses (p<0.001) 6 meses p (0,0001), 8 años (p<0.001). Los efectos adversos, fueron menor al 1%, y no tienen diferencias significativas (NS) en relación al grupo comparador. Rifaximina no tiene utilidad en la prevención de complicaciones (NS). La heterogeneidad clínica y metodológica debido a las diferentes mediciones de los desenlaces y definiciones del score sintomático, no permite establecer medidas combinadas del efecto. Conclusiones: Rifaximina es mejor que la fibra (glucomanano solo), superior a placebo en mejoria de los síntomas. Se requieren más estudios para confirmar estos hallazgos. Se recomienda realizar ECA bien diseñados para establecer el impacto de la rifaximina en EDSNC. (Texto tomado de la fuente).
dc.description.abstractRifaximin in uncomplicated symptomatic diverticular disease. Systematic review of the literature Introduction: Rifaximin is an antibiotic that inhibits bacterial RNA synthesis and has been proposed for the treatment of uncomplicated symptomatic diverticular disease (NCSD), but there is controversy about its usefulness. Objective: To determine the effectiveness and safety of rifaximin compared to other interventions or no intervention in improving the symptoms of patients with EDSNC. Materials and methods: We searched all databases up to July 2021 to identify clinical trials, other intervention studies, cohorts, or cases and controls that evaluated the effectiveness and safety of rifaximin versus other interventions or no intervention in improving symptoms. symptoms of patients with EDSNC. The methodological quality of the included studies was assessed according to the type of design. Qualitative synthesis was performed. Results: 1489 references were screened. Eighteen full-text references were reviewed, of which seven were excluded. 11 studies met inclusion and exclusion criteria. In the RCTs (clinical trials) there was an improvement in the global symptomatic score at 14+/-2 days p<0.005, 6 months (p<0.001), 12 months (p<0.001), 24 months (p<0.001) with differences statistically significant. In the quasi-experimental study and in the observational studies there was also a significant reduction at 3 months (p<0.001), 6 months p (0.0001), 8 years (p<0.001). Adverse effects were less than 1%, and have no significant differences (NS) in relation to the comparator group. Rifaximin has no utility in the prevention of complications (NS). The clinical and methodological heterogeneity due to the different measurements of the outcomes and definitions of the symptom score, does not allow to establish combined measures of the effect. Conclusions: Rifaximin is better than fiber (glucomannan alone), superior to placebo in symptom improvement. Further studies are required to confirm these findings. Well-designed RCTs are recommended to establish the impact of rifaximin on EDSNC.
dc.format.extentxi, 55, 7 páginas
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.publisherUniversidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/
dc.subject.ddc610 - Medicina y salud
dc.titleRifaximina en enfermedad diverticular sintomática no complicada. Revisión sistemática de la literatura
dc.typeTrabajo de grado - Especialidad Médica
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Medicina - Especialidad en Gastroenterología
dc.description.notesIncluye anexos
dc.description.degreelevelEspecialidades Médicas
dc.description.degreenameEspecialista en Gastroenterología
dc.identifier.instnameUniversidad Nacional de Colombia
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourlhttps://repositorio.unal.edu.co/
dc.publisher.departmentDepartamento de Medicina Interna
dc.publisher.facultyFacultad de Medicina
dc.publisher.placeBogotá, Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
dc.relation.indexedBireme
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.decsDivertículo
dc.subject.decsDiverticulum
dc.subject.decsSystematic Review
dc.subject.decsRevisión Sistemática
dc.subject.decsRifaximin
dc.subject.decsRifaximina
dc.subject.proposalRifaximina
dc.subject.proposalRifaximin
dc.subject.proposalEnfermedad diverticular no complicada
dc.subject.proposalUncomplicated diverticular disease
dc.subject.proposalRifaximine
dc.subject.proposalRifaximin
dc.title.translatedRifaximin in symptomatic uncomplicated diverticular disease. Systematic review of the literature
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2
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dcterms.audience.professionaldevelopmentEstudiantes
dcterms.audience.professionaldevelopmentGrupos comunitarios
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dcterms.audience.professionaldevelopmentMedios de comunicación
dcterms.audience.professionaldevelopmentPersonal de apoyo escolar
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