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La saliva como alternativa para la detección de drogas de abuso: una revisión sistemática de la literatura
dc.rights.license | Reconocimiento 4.0 Internacional |
dc.contributor.advisor | Chaves Silva, Diana Carolina |
dc.contributor.author | Hernandez Tilaguy, Lorena Sofia |
dc.date.accessioned | 2022-06-28T16:31:58Z |
dc.date.available | 2022-06-28T16:31:58Z |
dc.date.issued | 2022 |
dc.identifier.uri | https://repositorio.unal.edu.co/handle/unal/81634 |
dc.description | ilustraciones, graficas |
dc.description.abstract | El incremento en el consumo de drogas de abuso es una problemática mundial que afecta negativamente, no solo a la persona que decide consumir sino también a su entorno, la gran dificultad social que desencadena dicho consumo estimula a la comunidad científica a investigar sobre metodologías que ayuden a la detección de dichas sustancias. La detección de drogas de abuso en saliva es un tema que no cuenta con información detallada y consensuada, presentándose la necesidad de dar a conocer dichas metodologías con el fin de aportar evidencia científica que pueda ser usada en diferentes ámbitos poblacionales. El presente estudio tuvo como objetivo evaluar mediante una revisión sistemática los parámetros de desempeño analítico que presentan las pruebas de detección de drogas de abuso en saliva, mediante una búsqueda en las bases de datos: Pubmed, Scielo, Scopus, CINALH, Cochrane library, Redalyc y Doaj,, se tuvieron en cuenta artículos científicos (de tipo experimental, in vitro, in vivo, poblacional) con estudios de las drogas de abuso clásicas como: THC, cocaína, anfetaminas, benzodiacepinas y sobre nuevas sustancias psicoactivas. Se incluyeron 69 artículos de los últimos 10 años en los resultados y discusión donde se abarcó la toxicocinética de las drogas en saliva, se comparó dicha toxicocinética con otras matrices de análisis, se abarcaron los métodos de detección y los factores que influyen en la detección. Se concluye que la saliva es de utilidad en la detección de las drogas de abuso estudiadas tras un consumo agudo, sin embargo, se debe tener en cuenta diferentes variables que influyen en la detección de cada tipo de droga. (Texto tomado de la fuente) |
dc.description.abstract | The increase in the consumption of drugs of abuse is a global problem that adversely affects not only the person who decides to consume but also their environment, the great social difficulty that triggers such consumption stimulates the scientific community to investigate methodologies that help to the detection of these substances. The detection of drugs of abuse in saliva it is a topic that does not have detailed and consensual information, presenting the need to publicize these methodologies to provide scientific evidence that can be used in different population settings. The objective of this study was to evaluate, through a systematic review, the analytical performance parameters presented by the tests for the detection of drugs of abuse in saliva, through a search in the following databases: Pubmed, Scielo, Scopus, CINALH, Cochrane library, Redalyc and Doaj,, scientific articles (experimental, in vitro, in vivo, population) were taken into account with studies of classic drugs of abuse such as: THC, cocaine, amphetamines, benzodiazepines and on novel psychoactive substances. 69 articles from the last 10 years were included in the results and discussion where the toxicokinetic of drugs in saliva were covered, said toxicokinetic was compared with other analysis samples, detection methods and factors that influence detection were covered. It is concluded that saliva is useful in the detection of drugs of abuse studied after acute consumption, however, different variables that influence the detection of each type of drug must be considered. |
dc.format.extent | xvi, 112 páginas |
dc.format.mimetype | application/pdf |
dc.language.iso | spa |
dc.publisher | Universidad Nacional de Colombia |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ |
dc.subject.ddc | 610 - Medicina y salud::614 - Medicina Forense; incidencia de lesiones, heridas, enfermedades; medicina preventiva pública |
dc.subject.other | Pruebas de Toxicidad |
dc.subject.other | Toxicity Tests |
dc.title | La saliva como alternativa para la detección de drogas de abuso: una revisión sistemática de la literatura |
dc.type | Trabajo de grado - Maestría |
dc.type.driver | info:eu-repo/semantics/masterThesis |
dc.type.version | info:eu-repo/semantics/acceptedVersion |
dc.publisher.program | Bogotá - Medicina - Maestría en Toxicología |
dc.contributor.researchgroup | Sustancias Psicoactivas |
dc.description.degreelevel | Maestría |
dc.description.degreename | Magíster en Toxicología |
dc.description.researcharea | Sustancias Psicoactivas |
dc.identifier.instname | Universidad Nacional de Colombia |
dc.identifier.reponame | Repositorio Institucional Universidad Nacional de Colombia |
dc.identifier.repourl | https://repositorio.unal.edu.co/ |
dc.publisher.department | Departamento de Toxicología |
dc.publisher.faculty | Facultad de Medicina |
dc.publisher.place | Bogotá, Colombia |
dc.publisher.branch | Universidad Nacional de Colombia - Sede Bogotá |
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dc.rights.accessrights | info:eu-repo/semantics/openAccess |
dc.subject.proposal | Saliva |
dc.subject.proposal | Drogas ilicitas |
dc.subject.proposal | Diagnostico |
dc.subject.proposal | Análisis |
dc.subject.proposal | Detección de abuso de sustancias |
dc.subject.proposal | Saliva |
dc.subject.proposal | Illicit drugs |
dc.subject.proposal | Diagnosis |
dc.subject.proposal | Analysis |
dc.subject.proposal | Substance abuse detection |
dc.title.translated | Saliva as an alternative for the detection of drugs of abuse: a systematic review of the literature |
dc.type.coar | http://purl.org/coar/resource_type/c_bdcc |
dc.type.coarversion | http://purl.org/coar/version/c_ab4af688f83e57aa |
dc.type.content | Text |
dc.type.redcol | http://purl.org/redcol/resource_type/TM |
oaire.accessrights | http://purl.org/coar/access_right/c_abf2 |
dcterms.audience.professionaldevelopment | Estudiantes |
dcterms.audience.professionaldevelopment | Investigadores |
dcterms.audience.professionaldevelopment | Maestros |
dcterms.audience.professionaldevelopment | Público general |
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