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Contribución a la fitoquímica, a la evaluación de la actividad antioxidante y el posible efecto neuroprotector de la especie Polygala paniculata

dc.rights.licenseAtribución-CompartirIgual 4.0 Internacional
dc.contributor.advisorRojas Cardozo, Maritza Adelina
dc.contributor.advisorVasquez Londono, Carlos Alberto
dc.contributor.authorGonzalez Rodriguez, Miguel Oswaldo
dc.date.accessioned2022-08-18T21:46:06Z
dc.date.available2022-08-18T21:46:06Z
dc.date.issued2022-08-17
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/81970
dc.description
dc.description
dc.descriptionfotografías a color, ilustraciones, gráficas, tablas
dc.description.abstractLa herbolaria china ocupa un lugar muy importante dentro de las terapias que conforman la Medicina Tradicional China. En Colombia, por las limitaciones en la consecución de los medicamentos herbales de origen asiático es necesario encontrar especies medicinales similares en nuestra flora. Se escogió la especie Polygala paniculata por su cercanía taxonómica con la especie Polygala tenuifolia de la herbolaria en China, la cual cuenta con estudios previos sobre su efecto neuroprotector, constituyéndose en una especie promisoria para el tratamiento para enfermedades neurodegenerativas, que afectan la salud pública. Se estudió la fitoquímica de las raíces y de las partes aéreas de la especie Polygala paniculata, donde se detectaron metabolitos secundarios como flavonoides, terpenos/esteroides y cumarinas, además se evaluó su capacidad antioxidante y se analizó cualitativa y cuantitativamente la presencia de flavonoides. La comparación con la fitoquímica de Polygala tenuifolia mostró apreciables diferencias. La revisión bibliográfica realizada, vincula algunos flavonoides con el efecto neuroprotector, lo cual permite considerar los resultados preliminares como promisorios sobre el potencial neuroproctector de Polygala paniculata y se requerirá de investigaciones adicionales para su confirmación. (Texto tomado de la fuente)
dc.description.abstractContribution to the phytochemistry, the evaluation of the antioxidant activity and the possible neuroprotective effect of the species Polygala paniculata Chinese herbalism occupies a very important place within the therapies that make up Traditional Chinese Medicine. In Colombia, due to the limitations in obtaining herbal medicines of Asian origin, it is necessary to find similar medicinal species in our flora. The Polygala paniculata species was chosen due to its taxonomic closeness to the Polygala tenuifolia species of herbal medicine in China, which has previous studies on its neuroprotective effect, becoming a promising species for the treatment of neurodegenerative diseases that affect public health. The phytochemistry of the roots and aerial parts of the Polygala paniculata species was studied, where secondary metabolites such as flavonoids, terpenes/steroids and coumarins were detected, their antioxidant capacity was also evaluated and the presence of flavonoids was analyzed qualitatively and quantitatively. The comparison with the phytochemistry of Polygala tenuifolia showed appreciable differences. The bibliographic review carried out links some flavonoids with the neuroprotective effect, which allows us to consider the preliminary results as promising on the neuroprotective potential of Polygala paniculata and additional research will be required for confirmation.
dc.format.extentxvii, 72 páginas
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.publisherUniversidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/
dc.subject.ddc610 - Medicina y salud
dc.subject.ddc580 - Plantas
dc.titleContribución a la fitoquímica, a la evaluación de la actividad antioxidante y el posible efecto neuroprotector de la especie Polygala paniculata
dc.typeTrabajo de grado - Maestría
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Medicina - Maestría en Medicina Alternativa
dc.description.degreelevelMaestría
dc.description.degreenameMagíster en Medicina Alternativa
dc.description.researchareaAcupuntura y Medicina Tradicional China
dc.description.technicalinfoArchivo texto ilustrado a color en formato PDF
dc.description.technicalinfoColor illustrated text file in PDF format
dc.identifier.instnameUniversidad Nacional de Colombia
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourlhttps://repositorio.unal.edu.co/
dc.publisher.facultyFacultad de Medicina
dc.publisher.placeBogotá, Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.lembBioquímica vegetal
dc.subject.lembPlant biochemistry
dc.subject.proposalPolygala paniculata
dc.subject.proposalAntioxidante
dc.subject.proposalNeuroprotector
dc.subject.proposalFitoquímica
dc.subject.proposalFlavonoides
dc.subject.proposalNeurodegenerativo
dc.subject.proposalHerbolaria china
dc.subject.proposalAntioxidant
dc.subject.proposalNeuroprotective
dc.subject.proposalPhytochemical
dc.subject.proposalFlavonoids
dc.subject.proposalNeurodegenerative
dc.subject.proposalChinese herbal medicine
dc.title.translatedContribution to the phytochemistry, the evaluation of the antioxidant activity and the possible neuroprotective effect of the species Polygala paniculata
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
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