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dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.contributor.advisorBaena Aristizábal, Yolima
dc.contributor.authorOjeda Gómez, Sandra Xilena
dc.date.accessioned2022-08-24T17:48:34Z
dc.date.available2022-08-24T17:48:34Z
dc.date.issued2021
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/82076
dc.descriptionilustraciones, fotografías, graficas
dc.description.abstractEl aceite esencial de tomillo (AET) ha sido propuesto y respaldado por diversas investigaciones para su uso como promotor de crecimiento en pollos de engorde, sin embargo, su aplicación directa se dificulta debido a su inestabilidad asociada a su alta volatilización y oxidación. El objetivo de esta investigación fue microencapsularlo mediante secado por aspersión para mejorar sus propiedades farmacotécnicas y de estabilidad, empleando como biopolímeros de recubrimiento a la goma arábiga (G), la maltodextrina (M) y al almidón de ñame succinatado (AÑS). Se establecieron las condiciones de emulsificación y, mediante la aplicación de un diseño estadístico experimental (DEE), las de microencapsulación. El AET fue identificado y cuantificado por cromatografía de gases acoplada a espectroscopia de masas, sus componentes mayoritarios fueron D-limoneno (45,65%), timol (18,26%) y p-cimeno (15,30%). El quimiotipo identificado no coincidió con los reportados de Thymus Vulgaris, por lo cual se nombró como quimiotipo D-limoneno. Las condiciones de obtención de las micropartículas fueron: relación aceite/biopolímeros 1:6, biopolímeros G/M/AÑS, flujo de nitrógeno 601 L/h, flujo de aspiración 32 m3/h, flujo de alimentación 3 mL/min y temperatura de inyección 138°C. Se caracterizaron las micropartículas obtenidas en cuanto a propiedades organolépticas, rendimiento del proceso (48,5%), eficiencia de encapsulación (87,47%), eficiencia de carga (78,83%), tamaño de partícula (74,50 µm), span (2,36), fluidez (baja) y morfología (entre esférica y ovalada). El ensayo de estabilidad evidenció la protección física que proporcionó la cubierta polimérica al AET para disminuir su volatilización y las pérdidas presentadas podrían estar relacionadas con la porosidad de la matriz y la posible degradación de los componentes que hacen parte del aceite. Se sugiere que estas micropartículas cumplen con las propiedades farmacotécnicas básicas para evaluar su posible aplicación como promotor de crecimiento en la producción de pollos de engorde. (Texto tomado de la fuente)
dc.description.abstractThyme essential oil (TEO) has been proposed and supported in different researchs for its use as a growth promoter in broilers. However, its direct application is difficult due to its instability related to its high volatilization and oxidation. The aim of this research was to microencapsulate it by spray drying to improve its pharmacotechnical and stability properties, using gum arabic (G), maltodextrin (M) and succinated yam starch (SYS) as coating biopolymers. The emulsification conditions were established and, through the application of an experimental statistical design (ESD), the microencapsulation conditions. TEO was identified and quantified by gas chromatography coupled to mass spectroscopy; its main components were D-limonene (45.65%), thymol (18.26%) and p-cymene (15.30%). The identified chemotype did not coincide with those reported for Thymus Vulgaris, and for that reason it was named the D-limonene chemotype. The conditions for obtaining the microparticles were: oil/biopolymers ratio 1:6, G/M/SYS biopolymers, nitrogen flow 601 L/h, aspiration flow 32 m3/h, feeding flow 3 mL/min and temperature of injection 138°C. The microparticles obtained were characterized in terms of organoleptic properties, process yield (48,5%), encapsulation efficiency (87,47%), loading capacity (78,83%), particle size (74,50 µm), span (2,36), fluidity (low) and morphology (between spherical and oval). The stability test evidenced the physical protection provided by the polymeric coating to the TEO to reduce its volatilization and the losses presented could be related to the porosity of the matrix and the possible degradation of the components that are part of the oil. It is suggested that this microencapsulate meets the basic pharmacotechnical properties to evaluate its possible application as a growth promoter in the production of broilers.
dc.format.extentxix, 89 páginas
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.publisherUniversidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc540 - Química y ciencias afines
dc.titleAportes al desarrollo de un producto microencapsulado a base de aceite esencial de tomillo con posible aplicación en producción avícola
dc.typeTrabajo de grado - Maestría
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Ciencias - Maestría en Ciencias Farmacéuticas
dc.contributor.researchgroupGrupo de Investigación en Tecnología de Productos Naturales Tecprona
dc.description.degreelevelMaestría
dc.description.degreenameMagíster en Ciencias Farmacéuticas
dc.description.researchareaDiseño y desarrollo de productos fitofarmacéuticos
dc.identifier.instnameUniversidad Nacional de Colombia
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourlhttps://repositorio.unal.edu.co/
dc.publisher.departmentDepartamento de Farmacia
dc.publisher.facultyFacultad de Ciencias
dc.publisher.placeBogotá, Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
dc.relation.indexedRedCol
dc.relation.indexedLaReferencia
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.lembMICROENCAPSULADO
dc.subject.lembMicroencapsulation
dc.subject.proposalAceite esencial de tomillo
dc.subject.proposalPromotor de crecimiento
dc.subject.proposalMicroencapsulación
dc.subject.proposalSecado por aspersión
dc.subject.proposalAlmidón modificado
dc.subject.proposalThyme essential oil
dc.subject.proposalGrowth promoter
dc.subject.proposalMicroencapsulation
dc.subject.proposalSpray drying
dc.subject.proposalModified starch
dc.title.translatedContributions to the development of a microencapsulated product based on thyme essential oil with possible application in poultry production
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
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dc.type.redcolhttp://purl.org/redcol/resource_type/TM
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2
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