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Evaluación preclínica de la fracción butanólica de cálices de Physalis peruviana L. en modelo murino de artritis reumatoide

dc.rights.licenseAtribución-NoComercial 4.0 Internacional
dc.contributor.advisorOspina Giraldo, Luis Fernando
dc.contributor.authorUmaña Bautista, Stefany Rocio
dc.date.accessioned2023-07-31T20:41:56Z
dc.date.available2023-07-31T20:41:56Z
dc.date.issued2023
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/84382
dc.descriptionilustraciones, diagramas, fotografías
dc.description.abstractLa medicina tradicional se ha enfocado en estudiar los beneficios terapéuticos de plantas de la familia solanácea. En el caso de la planta Physalis peruviana L. se han descrito sus propiedades antiinflamatorias, antioxidantes e inmunomoduladoras. Sin embargo, en la actualidad no se ha reportado su uso en modelos murinos de inflamación crónica en artritis. Objetivo: Evaluar el posible efecto antiartrítico de la fracción butanólica de los cálices de Physalis peruviana L. en ratas Wistar hembras con artritis inducida por adyuvante completo de Freund (ACF) y colágeno. Método: La fracción butanólica de los cálices de Physalis peruviana L. se obtuvo a partir de la percolación con etanol de material seco, al cual se le hizo fraccionamiento con diferentes solventes hasta obtener la fracción butanólica. Se utilizó un modelo de inducción de artritis por adyuvante de Freund (ACF) y colágeno en ratas Wistar, evidenciando un pico de máxima inflamación el día 21. Los individuos fueron tratados desde el día 21 hasta el día 36 con dexametasona como medicamento patrón (1 mg/Kg/día) y la fracción butanólica (100, 50, 25 mg/Kg). La artritis fue evaluada a través de medición volumétrica de miembros posteriores (articulación del maléolo, zona plantar e interfalángica), evaluación radiográfica y análisis histopatológico. El efecto de la fracción butanólica sobre la inflamación se evaluó midiendo los niveles de interleucina 1 beta (IL-1β) y factor de necrosis tumoral alfa (TNFα); mientras que TBARs, la capacidad antioxidante (FRAP) y superóxido dismutasa (SOD) fueron medidos para evaluar el efecto de la fracción butanólica sobre el estrés oxidativo. Resultados: La fracción butanólica de cálices de Physalis peruviana L. no presentó diferencias significativas en la disminución de inflamación en comparación con el grupo patrón. Ninguno de los parámetros bioquímicos presentó diferencias significativas entre los grupos de investigación. La artritis inducida por ACF y colágeno no presentó involución de acuerdo con el análisis histopatológico y radiográfico. Conclusión: La fracción butanólica de cálices de Physalis peruviana L. (100, 50, 25 mg/Kg/día/VO) no presentó actividad inmunomoduladora ni antioxidante. Palabras clave: Physalis peruviana L., artritis, antioxidante, inmunomodulador, antiartrítico, erosión ósea y pannus. (Texto tomado de la fuente)
dc.description.abstractTraditional medicine has focused on studying the therapeutic benefits of plants from the Solanaceae family. In the case of the Physalis peruviana L plant, its anti-inflammatory, antioxidant and immunomodulation properties have been described. However, its use in models of chronic inflammation in induced arthritis in murine models has not been reported to date. Objective: To evaluate the possible antiarthritic effect of the butanolic fraction of the calyces of Physalis peruviana L. in female Wistar rats with arthritis induced by complete Freund's adjuvant (CFA) and collagen. Method: The butanolic fraction of the calyces of Physalis peruviana L. was obtained from the percolation with ethanol of dry material, which was fractionated with different solvents until obtaining the butanolic fraction. A Freund's adjuvant (FCA) and collagen induction model of arthritis was used in Wistar rats, evidencing a peak of maximum inflammation on day 21. Individuals were treated with dexamethasone as standard drug (1 mg/Kg/day) and the butanolic fraction. (100, 50, 25 mg/Kg) from day 21 to day 36. Arthritis was evaluated through volumetric measurement of hind limbs (malleolar joint, plantar and interphalangeal area), radiographic evaluation, and histopathological analysis. The effect of the butanolic fraction on inflammation was evaluated by measuring the levels of interleukin (IL-1β) and tumor necrosis factor (TNFα) while TBARs, antioxidant capacity (FRAP) and superoxide dismutase (SOD) were measured to assess the effect of the butanolic fraction on oxidative stress. Results: The butanolic fraction of calyces of Physalis peruviana L. does not present significant differences in the reduction of inflammation compared to the standard group. None of the biochemical parameters presented significant differences between the research groups. The arthritis induced by CFA and collagen does not present involution according to the histopathological and radiographic analysis. Conclusion: The butanolic fraction of calyces of Physalis peruviana L. (100, 50, 25 mg/Kg/day/VO) did not present immunomodulatory and antioxidant activity. Keywords: Physalis peruviana L., arthritis, antioxidant, immunomodulator, antiarthritic, bone erosion, pannus.
dc.format.extent130 páginas
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.publisherUniversidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.ddc610 - Medicina y salud::615 - Farmacología y terapéutica
dc.subject.ddc610 - Medicina y salud::616 - Enfermedades
dc.titleEvaluación preclínica de la fracción butanólica de cálices de Physalis peruviana L. en modelo murino de artritis reumatoide
dc.typeTrabajo de grado - Maestría
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Ciencias - Maestría en Ciencias - Farmacología
dc.contributor.researchgroupPrincipios Bioactivos en Plantas Medicinales
dc.description.degreelevelMaestría
dc.description.degreenameMagíster en Ciencias - Farmacología
dc.description.methodsLa fracción butanólica de los cálices de Physalis peruviana L. se obtuvo a partir de la percolación con etanol de material seco, al cual se le hizo fraccionamiento con diferentes solventes hasta obtener la fracción butanólica. Se utilizó un modelo de inducción de artritis por adyuvante de Freund (ACF) y colágeno en ratas Wistar, evidenciando un pico de máxima inflamación el día 21. Los individuos fueron tratados desde el día 21 hasta el día 36 con dexametasona como medicamento patrón (1 mg/Kg/día) y la fracción butanólica (100, 50, 25 mg/Kg). La artritis fue evaluada a través de medición volumétrica de miembros posteriores (articulación del maléolo, zona plantar e interfalángica), evaluación radiográfica y análisis histopatológico. El efecto de la fracción butanólica sobre la inflamación se evaluó midiendo los niveles de interleucina 1 beta (IL-1β) y factor de necrosis tumoral alfa (TNFα); mientras que TBARs, la capacidad antioxidante (FRAP) y superóxido dismutasa (SOD) fueron medidos para evaluar el efecto de la fracción butanólica sobre el estrés oxidativo.
dc.description.researchareaPlantas con actividad antiinflamatoria
dc.identifier.instnameUniversidad Nacional de Colombia
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourlhttps://repositorio.unal.edu.co/
dc.publisher.facultyFacultad de Ciencias
dc.publisher.placeBogotá,Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.lembBotánica médica
dc.subject.lembMedicine, botanic
dc.subject.lembMateria médica, vegetable
dc.subject.lembMateria medica, Vegetable
dc.subject.lembPlantas medicinales
dc.subject.lembMedicinal plant
dc.subject.proposalPhysalis peruviana L.
dc.subject.proposalArtritis
dc.subject.proposalAntioxidante
dc.subject.proposalInmunomodulador
dc.subject.proposalAntiartrítico
dc.subject.proposalErosión ósea
dc.subject.proposalPannus
dc.subject.proposalModelo murino de artritis
dc.subject.proposalArthritis
dc.subject.proposalAntioxidant
dc.subject.proposalImmunomodulator
dc.subject.proposalAntiarthritic
dc.subject.proposalBone erosion
dc.title.translatedPreclinical evaluation of the butanolic fraction of calyces of Physalis peruviana L. in a murine model of rheumatoid arthritis
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2
oaire.awardtitleEvaluación preclínica de la fracción butanólica de cálices de Physalis peruviana L. en modelo murino de artritis reumatoide
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dcterms.audience.professionaldevelopmentPadres y familias
dcterms.audience.professionaldevelopmentPersonal de apoyo escolar
dcterms.audience.professionaldevelopmentPúblico general
dc.contributor.orcidUmaña Bautista, Stefany
dc.contributor.cvlacUmaña Bautista, Stefany
dc.contributor.scopusUmaña Bautista, Stefany
dc.contributor.researchgateUmaña Bautista, Stefany
dc.contributor.googlescholarUmaña Bautista, Stefany


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