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Characterization of the sentinel lymph node to determine the micro-metastases presence

dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.contributor.advisorRomero Castro, Edgar Eduardo
dc.contributor.authorMolano Muñoz, Leidy Tatiana
dc.date.accessioned2023-09-04T14:18:53Z
dc.date.available2023-09-04T14:18:53Z
dc.date.issued2023
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/84633
dc.descriptionilustraciones, diagramas
dc.description.abstractEl ganglio linfático centinela es un predictor de agresividad del cáncer de mama. El índice de riesgos instantáneos informado fue de 2,14, intervalo de confianza del 95%, lo que muestra que los pacientes con micrometástasis (MM) tienen una mayor probabilidad de una peor supervivencia libre de enfermedad (SSE) y supervivencia general (SG) en comparación con aquellos que tienen ganglios. negativos, la detección temprana del análisis de micrometástasis parece ser el enfoque más ventajoso para los pacientes. Este trabajo propone una detección automática de micrometástasis mediante la cuantificación de cambios celulares locales. La estrategia propuesta caracteriza la morfometría, el color y la textura de los núcleos para establecer diferencias entre MM y el tejido normal. El modelo de color se obtiene del plano [(r − b), g] mientras que la textura corresponde a las características de Haralick de cinco órdenes diferentes de la matriz de coocurrencia. (Texto tomado de la fuente)
dc.description.abstractThe sentinel lymph node is a predictor of breast cancer aggressiveness. The hazard ratio reported was 2.14, 95% confidence interval, which shows that the patient with micro-metastasis (MM) have a higher probability of poorer Disease-free survival (DFS) and overall survival (OS) Relative to those who are node-negative, early detection of micro-metastasis analysis appears to be the approach most advantageous for patients. This work proposes an automatic detection of micro-metastasis by quantifying local cellular changes. The proposed strategy characterizes nuclei morphometry, color, and texture to establish differences between MM and normal tissue. The color model is obtained from the plane [(r − b), g] while texture corresponds to Haralick’s features from five different orders of the co-occurrence matrix. This description is complemented by the cellular area obtained from a conventional watershed segmentation.
dc.format.extentviii. 33 páginas
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc000 - Ciencias de la computación, información y obras generales::004 - Procesamiento de datos Ciencia de los computadores
dc.subject.ddc620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingeniería
dc.subject.ddc610 - Medicina y salud::616 - Enfermedades
dc.titleCharacterization of the sentinel lymph node to determine the micro-metastases presence
dc.typeTrabajo de grado - Maestría
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Medicina - Maestría en Ingeniería Biomédica
dc.contributor.researchgroupCim@Lab
dc.description.degreelevelMaestría
dc.description.methodsModelamiento y análisis de datos basados en técnicas de machine learning.
dc.description.researchareaProcesamiento de Imágenes
dc.description.researchareaPatología Digital
dc.identifier.instnameUniversidad Nacional de Colombia
dc.identifier.repoRepositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourlhttps://repositorio.unal.edu.co/
dc.publisher.facultyFacultad de Medicina
dc.publisher.placeBogotá, Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.decsGanglios
dc.subject.decsGanglia
dc.subject.decsGanglio linfático centinela
dc.subject.decsSentinel Lymph Node
dc.subject.decsDetección precoz del cáncer
dc.subject.decsEarly Detection of Cancer
dc.subject.proposalHistopathology
dc.subject.proposalDetection
dc.subject.proposalBreast Cancer
dc.subject.proposalMicro-Metastasis
dc.subject.proposalHistopatología
dc.subject.proposalCancer de mama
dc.subject.proposalDetección
dc.title.translatedCaracterización del ganglio linfático centinela para determinar la presencia de micro-metástasis
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
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oaire.awardtitlen/a
oaire.fundernamen/a
dcterms.audience.professionaldevelopmentEstudiantes
dcterms.audience.professionaldevelopmentInvestigadores
dcterms.audience.professionaldevelopmentMaestros
dcterms.audience.professionaldevelopmentPúblico general
dc.contributor.cvlacMolano Muñoz Leidy Tatiana
dc.contributor.scopusMolano, Leidy Tatiana
dc.contributor.googlescholarLeidy T. Molano


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Atribución-NoComercial-SinDerivadas 4.0 InternacionalEsta obra está bajo licencia internacional Creative Commons Reconocimiento-NoComercial 4.0.Este documento ha sido depositado por parte de el(los) autor(es) bajo la siguiente constancia de depósito