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Exploración de modificaciones estructurales de un antígeno de la proteína MSP1 de Plasmodium spp y su influencia en su propiedad de reconocimiento molecular por sueros murinos y humanos, de personas de áreas postconflicto en Colombia

dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional
dc.contributor.advisorLozano Moreno, José Manuel
dc.contributor.authorMelo Velanida, Fredy Leonardo
dc.date.accessioned2024-01-17T18:32:49Z
dc.date.available2024-01-17T18:32:49Z
dc.date.issued2023-11-07
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/85352
dc.descriptionilustraciones a color, diagramas, fotografías
dc.description.abstractEstudios realizados en el marco de investigación del grupo de mimetismo molecular de los agentes infecciosos, evaluaron la reactividad de sueros de áreas endémicas de Colombia (san juan de nepomuceno - bolívar, tierralta - córdoba, nuquí - chocó y tumaco - nariño) (SIVIGILA, instituto nacional de salud, 2018), frente a lisados de dos cepas de referencia, 3D7 y FCB2 de Plasmodium falciparum, donde se identificaron bandas de reconocimiento de la proteína MSP1 con movilidades relativas de 195, 83, 42 y 38 kDa, que permitieron identificar la reactividad de sueros frente a la proteína precursora MSP1 y sus fragmentos de procesamiento, lo que valida la importancia de este antígeno de superficie respecto a su papel inmunológico, perfilándola como una proteína blanco en la implementación de modificaciones tipo amida reducida, que promuevan y evidencien una protección efectiva de individuos expuestos a la infección natural. (Texto tomado de la fuente)
dc.description.abstractStudies carried out within the research framework of the molecular mimicry of infectious agents group, evaluated the reactivity of sera from endemic areas of Colombia (San Juan de Nepomuceno - Bolívar, Tierralta - Córdoba, Nuquí - Chocó and Tumaco - Nariño) (SIVIGILA, national institute of health, 2018), compared to lysates of two reference strains, 3D7 and FCB2 of Plasmodium falciparum, where recognition bands of the MSP1 protein were identified with relative mobilities of 195, 83, 42 and 38 kDa, which allowed the identification the reactivity of sera against the MSP1 precursor protein and its processing fragments, which validates the importance of this surface antigen with respect to its immunological role, profiling it as a target protein in the implementation of reduced amide type modifications, which promote and demonstrate effective protection of individuals exposed to natural infection.
dc.description.sponsorshipLa Convocatoria para el Apoyo a Proyectos de Investigación y Creación Artística de la Sede Bogotá de la Universidad Nacional de Colombia - 2019, tiene como objetivo fortalecer el desarrollo de la investigación y la creación artística, contribuir a la formación en procesos de investigación y extensión de estudiantes de pregrado y posgrado, y generar impacto mediante el reconocimiento y visibilidad de la Universidad Nacional de Colombia de la sede Bogotá, a través de la producción académica asociada al desarrollo de proyectos de investigación.
dc.format.extent[100] páginas
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.publisherUniversidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subject.ddc610 - Medicina y salud::615 - Farmacología y terapéutica
dc.subject.ddc610 - Medicina y salud::616 - Enfermedades
dc.titleExploración de modificaciones estructurales de un antígeno de la proteína MSP1 de Plasmodium spp y su influencia en su propiedad de reconocimiento molecular por sueros murinos y humanos, de personas de áreas postconflicto en Colombia
dc.typeTrabajo de grado - Maestría
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Ciencias - Maestría en Ciencias - Farmacología
dc.contributor.researchgroupMimetismo Molecular de Los Agentes Infecciosos
dc.coverage.countryColombia
dc.description.degreelevelMaestría
dc.description.degreenameMagister en Ciencias - Farmacología
dc.description.researchareaCiencias Médicas y de la Salud - Biotecnología en Salud
dc.identifier.instnameUniversidad Nacional de Colombia
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourlhttps://repositorio.unal.edu.co/
dc.publisher.facultyFacultad de Ciencias
dc.publisher.placeBogotá, Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.decsSimulación del acoplamiento molecular
dc.subject.decsMolecular docking simulation
dc.subject.decsPlasmodium falciparum
dc.subject.decsPlasmodium berghei
dc.subject.decsAntígenos de protozoos
dc.subject.decsAntigens, protozoan
dc.subject.decsPlasmodium yoelii
dc.subject.decsMalaria-Tratamiento farmacológico
dc.subject.decsTécnicas Inmunológicas
dc.subject.decsImmunologic techniques
dc.subject.proposalProteína MSP1
dc.subject.proposalPlasmodium falciparum 3D7
dc.subject.proposalPlasmodium berghei ANKA
dc.subject.proposalPlasmodium yoelii 17XL
dc.subject.proposalMalaria
dc.subject.proposalModificación amida reducida
dc.subject.proposalAcoplamiento molecular
dc.subject.proposalMSP1 protein
dc.subject.proposalReduced amide modification
dc.subject.proposalMolecular docking
dc.title.translatedExploration of structural modifications of an MSP1 protein antigen from Plasmodium spp and their influence on its molecular recognition property by murine and human sera from people from post-conflict areas in Colombia
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2
oaire.awardtitleConvocatoria para el apoyo a proyectos de investigación y creación artística de la sede Bogotá de la Universidad Nacional de Colombia - 2019
oaire.fundernameUniversidad Nacional de Colombia
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dcterms.audience.professionaldevelopmentConsejeros
dcterms.audience.professionaldevelopmentEstudiantes
dcterms.audience.professionaldevelopmentGrupos comunitarios
dcterms.audience.professionaldevelopmentInvestigadores
dcterms.audience.professionaldevelopmentMaestros
dcterms.audience.professionaldevelopmentMedios de comunicación
dcterms.audience.professionaldevelopmentPadres y familias
dcterms.audience.professionaldevelopmentPersonal de apoyo escolar
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