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Estudio de los fenómenos de transporte de masa a escala microscópica, para su aplicación en el diseño de sistemas de liberación modificada del tipo película polimérica

dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional
dc.contributor.advisorVallejo Díaz, Bibiana Margarita
dc.contributor.authorRodríguez Vera, Edward Andrés
dc.date.accessioned2024-01-22T20:02:36Z
dc.date.available2024-01-22T20:02:36Z
dc.date.issued2023-08-02
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/85403
dc.descriptionilustraciones, diagramas, fotografías
dc.description.abstractEn esta investigación se estudiaron los fenómenos de transporte de masa y momento en un dispositivo de dimensiones milimétricas, fabricado con el propósito de recrear un modelo simplificado de cavidad nasal; este dispositivo permite la inserción de una película polimérica y el flujo de un fluido simulado de sangre. La descripción de estos fenómenos se realizó a través del planteamiento de un modelo matemático que fue discretizado con un esquema combinado de diferencias finitas centradas y diferencias finitas hacia atrás, incorporando un método de avance temporal semi-implícito. Para validar el modelo matemático se realizó un experimento que consiste en insertar una película polimérica cargada de rodamina dentro del dispositivo de estudio y se capturan imágenes en un microscopio de fluorescencia a diferentes tiempos; por otro lado, a la salida del dispositivo se recolectan muestras que se cuantifican posteriormente por medio de un espectrofotómetro UV-vis. También, se desarrollaron una serie de experimentos complementarios que retroalimentan la simulación. El resultado de las operaciones computacionales sumado a la estandarización del método de elaboración de películas seleccionado (vertimiento en placa) permitió aplicar bases científicas y matemáticas al diseño de películas poliméricas siguiendo algunos conceptos de la metodología del Diseño Integrado de Producto y Proceso. Gracias a los experimentos y las herramientas computacionales, se plantearon una serie de casos para el análisis de la influencia de parámetros en el desempeño de la liberación de películas poliméricas. (Texto tomado de la fuente).
dc.description.abstractIn the current research, the mass and momentum transport phenomena were studied in a device of millimeter dimensions, manufactured with the purpose of recreating a simplified model of the nasal cavity; this device allows the insertion of a polymeric film and the flow of a simulated blood fluid. Phenomena description was carried out through the approach of a mathematical model that was discretized with a combined centered finite differences and backwards finite differences schemes, incorporating a semi-implicit time advance method. To validate the mathematical model, it was developed an experiment that consists of inserting a rhodamine-loaded polymeric film inside the study device and capturing images in a fluorescence microscope at different times; on the other hand, at the exit of the device, samples are collected and quantified by means of a UV-vis spectrophotometer. Also, a series of complementary experiments were elaborated to feed back the simulation. The results of the computational operations added to the standardization method to produce films (casting) allowed to apply scientific and mathematical bases to polymeric films design following some concepts of the Integrated Product and Process Development methodology. As a result of the experiments and the computational tools, a series of cases were raised for the analysis of the influence of parameters on the release performance of polymeric films.
dc.format.extentxviii, 148 páginas
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.publisherUniversidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subject.ddc000 - Ciencias de la computación, información y obras generales::005 - Programación, programas, datos de computación
dc.subject.ddc530 - Física::532 - Mecánica de fluidos
dc.subject.ddc610 - Medicina y salud::615 - Farmacología y terapéutica
dc.titleEstudio de los fenómenos de transporte de masa a escala microscópica, para su aplicación en el diseño de sistemas de liberación modificada del tipo película polimérica
dc.typeTrabajo de grado - Maestría
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Ciencias - Maestría en Ciencias Farmacéuticas
dc.contributor.researchgroupInvestigación en Procesos de Transformación de Materiales Para la Industria Farmacéutica
dc.description.degreelevelMaestría
dc.description.degreenameMagíster en Ciencias Farmacéuticas
dc.description.researchareaFarmacotecnia e ingeniería farmacéutica
dc.identifier.instnameUniversidad Nacional de Colombia
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourlhttps://repositorio.unal.edu.co/
dc.publisher.facultyFacultad de Ciencias
dc.publisher.placeBogotá, Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
dc.relation.indexedBireme
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.decssistemas de liberación de medicamentos
dc.subject.decsDrug Delivery Systems
dc.subject.decsdiseño de fármacos
dc.subject.decsDrug Design
dc.subject.decsmecánica de fluidos
dc.subject.decsFlow Mechanics
dc.subject.proposalMIcrofluidos
dc.subject.proposalPelícula polimérica
dc.subject.proposalMIcrofluidics
dc.subject.proposalPolymeric film
dc.subject.proposalDinámica de fluidos computacional
dc.subject.proposalSistemas de liberación modificada
dc.subject.proposalDiseño integrado de producto y proceso
dc.subject.proposalComputational fluid dynamics
dc.subject.proposalModified release system
dc.subject.proposalIntegrated product and process development
dc.title.translatedStudy of mass transport phenomena at a microscopic scale, for its application in the design of modified release systems of the polymeric film type
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2
oaire.fundernameFacultad de Ciencias - Universidad Nacional de Colombia
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