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Análisis computacional de la hemaglutinina de los virus influenza A de linaje pandémico en Colombia
dc.rights.license | Atribución-NoComercial 4.0 Internacional |
dc.contributor.advisor | Hernández Ortiz, Juan Pablo |
dc.contributor.advisor | Ciuoderis Aponte, Karl Adolf |
dc.contributor.author | Úsuga Restrepo, Jaime Andrés |
dc.date.accessioned | 2024-01-24T20:14:33Z |
dc.date.available | 2024-01-24T20:14:33Z |
dc.date.issued | 2023-08-01 |
dc.identifier.uri | https://repositorio.unal.edu.co/handle/unal/85425 |
dc.description | Ilustraciones |
dc.description.abstract | Aunque se ha demostrado la amplia circulación del virus influenza (VI) A en cerdos y humanos en el mundo y en Colombia, existen pocos estudios que hayan caracterizado los aspectos biológicos de estos virus. Por tanto, éste trabajo se basó en el análisis computacional de la proteína de superficie hemaglutinina (HA) de cepas pandémicas del VI circulantes en el país, y su relación con un cambio en las propiedades biológicas de estos. Este trabajo se desarrolló en tres capítulos, en el primero se caracterizó la composición genómica de la HA, seguido de la identificación de las mutaciones en esta proteína y su posible contribución a la diseminación de estos virus en la región. Los últimos dos capítulos, correspondieron al análisis estructural de la HA y su interacción con los receptores celulares. En general, se sugiere que las mutaciones I322V, P84S, S204T, E375K entre otras, pudieron haber contribuido al fitness y en el establecimiento de estos virus en las poblaciones actuales en Colombia. Las mutaciones más relevantes (E375K y S163N) estaban relacionadas con el aumento de la virulencia y la capacidad de evadir la respuesta inmune. Adicionalmente, se observó un clúster filogenéticamente relacionado que presentó dos mutaciones únicas (D223X y Q224X) no reportadas previamente. Por otra parte, para los modelos de los consensos tridimensionales de la HA, se observó que el modelo cBri18 (con mutaciones únicas R46G, P283A y I299V), representativo de su clúster, mostró comportamientos estructurales ligeramente distintos a los otros modelos y presentó cambios en el loop130 del sitio de unión al receptor. Adicionalmente, luego del análisis de los modelos de HA más relevantes, se encontró que estos mantienen preferencia la unión con los receptores celulares humanos (SA2,6) sobre los aviares (SA2,3). También que el modelo cCal09 tuvo mayor afinidad por SA2,6; y que el modelo cBri18 fue el única interactuó con SA2,3, hecho que puede atribuirse a los cambios evidenciados en el loop130. En conclusión, la presencia de ciertas mutaciones en la proteína HA de VI H1N1pdm de Colombia están posiblemente influenciando las propiedades biológicas de estos virus, sin embargo, otros estudios son necesarios para poder confirmar estos hallazgos. No obstante, este conocimiento generado aporta en el fortalecimiento de las acciones en la vigilancia y control de estos virus en el país y la región. (texto tomado de la fuente) |
dc.description.abstract | Despite circulation of influenza virus (IV) in pigs and humans globally, few studies have characterized its biological features in Colombia. Therefore, in this study a computational analysis of the hemagglutinin (HA) surface protein of IV pandemic strains circulating in the country, and its relationship with a change in their biological properties was carried out. This work was developed in three chapters, in the first one, the genomic composition of HA was characterized, followed by the identification of the mutations and their possible contribution to the dissemination of these viruses in the region. The last two chapters corresponded to the structural analysis of HA and its interaction with cell receptors. In general, the mutations I322V, P84S, S204T, E375K, among others, have contributed to the fitness and establishment of these viruses in current populations in Colombia. The most relevant changes (E375K and S163N) were related to increased virulence and the ability to evade the immune response. In addition, a phylogenetically related cluster was found that exhibited two unique changes (D223X and Q224X) not previously reported. On the other hand, for the three-dimensional consensus models of the HA, it was shown that the cBri18 model (with exclusive mutations R46G, P283A and I299V), representative of its cluster, showed structural changes in the loop130 of receptor binding domain behaviors slightly different from the other models. In addition, analyzing the most relevant HA models, it was found that they preferentially bind to human cell receptors (SA2,6) over avian (SA2,3). Also, that the cCal09 model had a higher affinity for SA2,6; and that the cBri18 model was the only one that interacted with SA2,3, a fact that can be attributed to the changes observed in loop130. In conclusion, the presence of certain mutations in the HA protein of IV H1N1pdm from Colombia might be influencing the biological properties of these viruses, however, other studies are necessary to confirm these findings. However, this generated knowledge contributes to strengthening actions in the surveillance and control of these viruses in the country and the region. |
dc.format.extent | 103 páginas |
dc.format.mimetype | application/pdf |
dc.language.iso | spa |
dc.publisher | Universidad Nacional de Colombia |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ |
dc.subject.ddc | 570 - Biología |
dc.title | Análisis computacional de la hemaglutinina de los virus influenza A de linaje pandémico en Colombia |
dc.type | Trabajo de grado - Maestría |
dc.type.driver | info:eu-repo/semantics/masterThesis |
dc.type.version | info:eu-repo/semantics/acceptedVersion |
dc.publisher.program | Medellín - Minas - Maestría en Ingeniería - Materiales y Procesos |
dc.contributor.researchgroup | Crs-Tid Center for Research and Surveillance of Tropical and Infectious Diseases |
dc.description.degreelevel | Maestría |
dc.description.degreename | Magíster en Ingeniería - Materiales y Procesos |
dc.description.researcharea | Bioinformática |
dc.description.researcharea | Virología |
dc.identifier.instname | Universidad Nacional de Colombia |
dc.identifier.reponame | Repositorio Institucional Universidad Nacional de Colombia |
dc.identifier.repourl | https://repositorio.unal.edu.co/ |
dc.publisher.faculty | Facultad de Minas |
dc.publisher.place | Medellín, Colombia |
dc.publisher.branch | Universidad Nacional de Colombia - Sede Medellín |
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dc.rights.accessrights | info:eu-repo/semantics/openAccess |
dc.subject.lemb | Dinámica molecular |
dc.subject.lemb | Variación genética |
dc.subject.lemb | Virus de la influenza |
dc.subject.proposal | HA |
dc.subject.proposal | Influenza virus |
dc.subject.proposal | Influenza |
dc.subject.proposal | Diversidad genética |
dc.subject.proposal | Dinámica molecular |
dc.subject.proposal | Mutaciones |
dc.subject.proposal | Docking |
dc.subject.proposal | Genetic diversity |
dc.subject.proposal | Molecular dynamics |
dc.subject.proposal | Mutations |
dc.title.translated | Computational analysis of the hemagglutinin of pandemic lineage influenza A viruses in Colombia |
dc.type.coar | http://purl.org/coar/resource_type/c_bdcc |
dc.type.coarversion | http://purl.org/coar/version/c_ab4af688f83e57aa |
dc.type.content | Text |
dc.type.redcol | http://purl.org/redcol/resource_type/TM |
oaire.accessrights | http://purl.org/coar/access_right/c_abf2 |
dcterms.audience.professionaldevelopment | Investigadores |
dc.description.curriculararea | Área Curricular de Materiales y Nanotecnología |
dc.contributor.orcid | 0009-0005-2830-908X |
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