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Modelo y simulación de dinámica de crecimiento de mieloma

dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.contributor.advisorGarzón Alvarado, Diego Alexander
dc.contributor.authorSánchez Gutiérrez, Juan Felipe
dc.date.accessioned2024-02-26T19:10:45Z
dc.date.available2024-02-26T19:10:45Z
dc.date.issued2024-02
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/85721
dc.descriptionilustraciones, diagramas
dc.description.abstractEn este trabajo se presentan tres capítulos con modelos in-silico desarrollados a través de ecuaciones diferenciales y solucionados computacionalmente, que proporcionan una perspectiva del acoplamiento entre el ciclo de remodelación ósea y las poblaciones tumorales. Comprender las dinámicas entre el tejido sano, las células que realizan el proceso de remodelación y las diferentes patologías, como el osteosarcoma o los tumores metastásicos, es fundamental para crear estrategias m´as personalizadas y especializadas para mitigar los efectos de estas enfermedades o curarlas por completo. Los modelos presentados proveen información mas detallada de la dinámica real de la remodelación ósea en pacientes por masas tumorales. Ofrecen un marco innovador y una base solida para el desarrollo de nuevos modelos, herramientas y técnicas que permitan el desarrollo de la medicina personalizada, con una perspectiva mas completa y controlada de los procesos fisiológicos y patológicos. Se espera que en el futuro, estos modelos sean aun mas robustos y versátiles, brindando un mayor apoyo para la toma de decisiones mas acertadas en cada caso clínico particular. (Texto tomado de la fuente).
dc.description.abstractThis work presents three chapters with in-silico models developed through differential equations and computationally solved, providing a perspective of the coupling between the bone remodeling cycle and tumor populations. Understanding the dynamics between healthy tissue, cells involved in the remodeling process, and different pathologies, such as osteosarcoma or metastatic tumors, is fundamental for creating more personalized and specialized strategies to mitigate the effects of these diseases or cure them completely. The models presented provide more detailed information about the real dynamics of bone remodeling in patients with tumor masses. They offer an innovative framework and a solid foundation for the development of new models, tools, and techniques that enable personalized medicine, with a more comprehensive and controlled perspective of physiological and pathological processes. It is expected that in the future, these models will become even more robust and versatile, providing greater support for making more accurate decisions in each specific clinical case.
dc.format.extentxvi, 103 páginas
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.publisherUniversidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc000 - Ciencias de la computación, información y obras generales::004 - Procesamiento de datos Ciencia de los computadores
dc.subject.ddc610 - Medicina y salud::616 - Enfermedades
dc.titleModelo y simulación de dinámica de crecimiento de mieloma
dc.typeTrabajo de grado - Maestría
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Ingeniería - Maestría en Ingeniería - Ingeniería Mecánica
dc.contributor.researchgroupGnum Grupo de Modelado y Métodos Numericos en Ingeniería
dc.description.degreelevelMaestría
dc.description.degreenameMagíster en Ingeniería Mecánica
dc.description.researchareaIngeniería de diseño y biomecánica
dc.identifier.instnameUniversidad Nacional de Colombia
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourlhttps://repositorio.unal.edu.co/
dc.publisher.facultyFacultad de Ingeniería
dc.publisher.placeBogotá, Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
dc.relation.indexedBireme
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.decsmieloma múltiple
dc.subject.decsMultiple Myeloma
dc.subject.decsmodelos teóricos
dc.subject.decssimulación por ordenador
dc.subject.decsComputer Simulation
dc.subject.proposalRemodelación ósea
dc.subject.proposalCrecimiento tumoral
dc.subject.proposalTumor
dc.subject.proposalModelo de Komarova
dc.subject.proposalOsteoclastos
dc.subject.proposalOsteoblastos
dc.subject.proposalBone remodeling
dc.subject.proposalTumor Growth
dc.subject.proposalTumor
dc.subject.proposalCoupling tumor–bone
dc.subject.proposalKomarova’s model
dc.subject.proposalOsteoclasts
dc.subject.proposalOsteoblasts
dc.subject.proposalCoplamiento tumor hueso
dc.title.translatedModel and Simulation of dynamics of myeloma growth
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2
dcterms.audience.professionaldevelopmentInvestigadores
dcterms.audience.professionaldevelopmentPúblico general
dc.contributor.orcidJUAN FELIPE SANCHEZ GUTIERREZ, [0000-0002-7821-5234]


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