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Efecto de la restricción proteica como modulador de la respuesta inmune del Tracto gastrointestinal de ratones BALB/c infectados con Leishmania infantumntum

dc.rights.licenseAtribución-NoComercial 4.0 Internacional
dc.contributor.advisorUmaña Péres, Yadi Adriana
dc.contributor.authorGaitán Albarracín, Felipe Andrés
dc.date.accessioned2024-05-07T13:31:49Z
dc.date.available2024-05-07T13:31:49Z
dc.date.issued2022
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/86037
dc.descriptionilustraciones, gráficas, mapas, tablas
dc.description.abstractLa desnutrición proteica es la causa más frecuente de inmunodeficiencia secundaria que conlleva a alteraciones del sistema inmune innato y adaptativo, generando la colonización y proliferación de agentes patogénicos, convirtiéndose en uno de los principales factores de riesgo para el desarrollo de formas clínicas de leishmania visceral (LV). Usando como modelo biológico ratones BALB/c, nuestro grupo de investigación mostró que animales sometidos a restricción proteica e infección con L. infantum, presentan graves atrofias en órganos linfoides, alteraciones en las subpoblaciones de linfocitos T y en niveles de expresión de factores quimiotácticos en timo y bazo. Esas alteraciones sugieren que una precondición de desnutrición proteica afecta la respuesta inmune frente a L. infantum, modificando la migración de células T y la capacidad de controlar la proliferación de parásitos. Aunque un patrón diseminación y respuesta inmune órgano especifica aún no ha sido claramente elucidado para el tracto gastrointestinal, algunos estudios reportan la aparición de estos parásitos en mucosa intestinal. Nuestro objetivo fue evaluar la influencia de la restricción proteica en la respuesta inmune en tracto gastrointestinal de ratones BALB/c frente a la infección con L. infantum, observando como la infección y desnutrición generaron alteraciones inmunes en función del reclutamiento linfocitario tisular, alteraciones estructurales del tejido intestinal y alteraciones en la respuesta inmune adaptativa celular mediada por citoquinas y humoral a través de la secreción de Inmunoglobulina A de forma diferencial para el intestino delgado y grueso. (Texto tomado de la fuente)
dc.description.abstractProtein malnutrition is the most frequent cause of secondary immunodeficiency that leads to alterations of the innate and adaptive immune system, generating the colonization and proliferation of pathogenic agents, becoming one of the main risk factors for the development of clinical forms of visceral leishmania (LV). Using BALB/c mice as a biological model, our research group showed that animals subjected to protein restriction and infection with L. infantum present severe atrophies in lymphoid organs, alterations in T lymphocyte subpopulations and in expression levels of chemotactic factors in thymus and spleen. These alterations suggest that a precondition of protein malnutrition affects the immune response against L. infantum, modifying the migration of T cells and the ability to control the proliferation of parasites. Although a pattern of dissemination and organ-specific immune response has not yet been clearly elucidated for the gastrointestinal tract, some studies report the appearance of these parasites in the intestinal mucosa. Our objective was to evaluate the influence of protein restriction on the immune response in the gastrointestinal tract of BALB/c mice against infection with L. infantum, observing how infection and malnutrition generated immune alterations based on tissue lymphocyte recruitment, structural alterations of the intestinal tissue and alterations in the cellular adaptive immune response mediated by cytokines and humoral through the secretion of Immunoglobulin A differentially for the small and large intestine.
dc.format.extentxii, 74 páginas
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.publisherUniversidad Nacional de Colombia
dc.rightsDerechos reservados al autor, 2024
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.ddc570 - Biología::572 - Bioquímica
dc.titleEfecto de la restricción proteica como modulador de la respuesta inmune del Tracto gastrointestinal de ratones BALB/c infectados con Leishmania infantumntum
dc.typeTrabajo de grado - Doctorado
dc.type.driverinfo:eu-repo/semantics/doctoralThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Ciencias - Doctorado en Ciencias - Estadística
dc.contributor.researchgroupGrupo de Investigación en Hormonas
dc.description.degreelevelDoctorado
dc.description.degreenameDoctor en Ciencias - Bioquímica
dc.description.researchareaEje GH/IGF-I y Nutrición
dc.identifier.instnameUniversidad Nacional de Colombia
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourlhttps://repositorio.unal.edu.co/
dc.publisher.facultyFacultad de Ciencias
dc.publisher.placeBogotá, Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.decsDeficiencia de Proteína
dc.subject.decsProtein Deficiency
dc.subject.decsLeishmania
dc.subject.decsTracto Gastrointestinal
dc.subject.decsGastrointestinal Tract
dc.subject.proposalIgA
dc.subject.proposalLeishmania infantum
dc.subject.proposalDuodeno
dc.subject.proposalGUT
dc.subject.proposalInflamación
dc.subject.proposalMalnutrición
dc.subject.proposalleishmaniasis visceral
dc.title.translatedEffect of protein restriction as a modulator of the immune response of the gastrointestinal tract of BALB/c mice infected with Leishmania infantum
dc.type.coarhttp://purl.org/coar/resource_type/c_db06
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.redcolhttp://purl.org/redcol/resource_type/TD
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2
dcterms.audience.professionaldevelopmentEstudiantes
dcterms.audience.professionaldevelopmentInvestigadores


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