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Estudio de la formación de azaciclofanos derivados de L-Tirosina y su interacción con zinc

dc.rights.licenseAtribución-NoComercial 4.0 Internacional
dc.contributor.advisorQuevedo Pastor, Ariel Rodolfo
dc.contributor.authorCháves Sánchez, Sebastián Camilo
dc.date.accessioned2024-05-14T20:16:07Z
dc.date.available2024-05-14T20:16:07Z
dc.date.issued2024-04-18
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/86083
dc.descriptionilustraciones, diagramas
dc.description.abstractEn este trabajo se estudió la síntesis de azaciclofanos derivados de L-tirosina empleando la estrategia de síntesis denominada “Síntesis asistida por enlace de hidrógeno”. Los resultados permiten establecer que la estrategia de síntesis permite obtener azaciclofanos pentacíclicos simétricos por reacciones de 2 componentes y asimétricos por reacciones de 3 componentes. Esta estrategia de síntesis permite obtener ciclofanos bencílicos simétricos con sustituyentes sobre el nitrógeno por reacciones de dos componentes y asimétricos por reacción de tres componentes. Cabe mencionar que efectos estéricos e interacciones ácido-base pueden influir en el curso de la reacción para la obtención del producto macrocíclico u oligómeros lineales. Se determino que los azaciclofanos derivados de L-tirosina interactúan con Zn 2+ por la periferia del macrociclo por la parte alifática y que su relación estequiométrica es 1:1 entre el azaciclofano y el metal, con la mayoría de ciclofanos estudiados. (Texto tomado de la fuente).
dc.description.abstractIn this work, the synthesis of azacyclophanes derived from L-tyrosine was studied using the synthesis strategy called “Hydrogen bond-assisted synthesis”. The results allow us to establish that the synthesis strategy allows obtaining symmetrical pentacyclic azacyclophanes by 2-component reactions and asymmetric by 3-component reactions. This synthesis strategy allows obtaining symmetrical benzylic cyclophanes with substituents on the nitrogen by two-component reactions and asymmetrical ones by three-component reaction. It is worth mentioning that steric effects and acid-base interactions can influence the course of the reaction to obtain the macrocyclic product or linear oligomers. It was determined that azacyclophanes derived from L-tyrosine interact with Zn2+ at the periphery of the macrocycle on the aliphatic part and that their stoichiometric relationship is 1:1 between azacyclophane and the metal, with the majority of cyclophanes studied.
dc.format.extentxxix, 157 páginas
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.publisherUniversidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.ddc540 - Química y ciencias afines::547 - Química orgánica
dc.titleEstudio de la formación de azaciclofanos derivados de L-Tirosina y su interacción con zinc
dc.typeTrabajo de grado - Doctorado
dc.type.driverinfo:eu-repo/semantics/doctoralThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Ciencias - Doctorado en Ciencias - Química
dc.contributor.researchgroupQuímica Macrocíclica
dc.description.degreelevelDoctorado
dc.description.degreenameDoctor en Ciencias - Química
dc.description.researchareaSíntesis orgánica
dc.identifier.instnameUniversidad Nacional de Colombia
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourlhttps://repositorio.unal.edu.co/
dc.publisher.facultyFacultad de Ciencias
dc.publisher.placeBogotá, Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.decsTirosina/química
dc.subject.decsTyrosine/chemistry
dc.subject.proposalAzaciclofanos
dc.subject.proposalL - tirosina
dc.subject.proposalAzacyclophanes
dc.subject.proposalL - tyrosine
dc.subject.proposalMannich type reaction
dc.subject.proposalhydrogen bond
dc.subject.proposalAmina
dc.subject.proposalReacción tipo Mannich
dc.subject.proposalFormaldehído
dc.subject.proposalEnlace de hidrógeno
dc.subject.proposalAmine
dc.subject.proposalFormaldehyde
dc.subject.unescoInvestigación química
dc.subject.unescoChemical research
dc.title.translatedStudy of the formation of azacyclophanes derived from L-Tyrosine and its interaction with zinc
dc.type.coarhttp://purl.org/coar/resource_type/c_db06
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.redcolhttp://purl.org/redcol/resource_type/TD
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2
dcterms.audience.professionaldevelopmentInvestigadores
dcterms.audience.professionaldevelopmentMaestros
dc.contributor.orcidChaves, Sebastián [0000-0001-7479-7858]
dc.contributor.cvlacChaves, Sebastian [0001703007]
dc.contributor.researchgateChaves, Sebastián [Sebastian-Chaves-Sanchez]
dc.contributor.googlescholarChaves, Sebastián [e2tLfbwAAAAJ]
dc.subject.wikidataMacrociclo
dc.subject.wikidatamacrocycle


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