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Evaluación y análisis antigénico de virus de campo como candidatos para la actualización del diagnóstico serológico de Influenza en cerdos en Colombia

dc.rights.licenseAtribución-NoComercial 4.0 Internacional
dc.contributor.advisorRamírez Nieto, Gloria Consuelo
dc.contributor.advisorRincón Monroy, Maria Antonia
dc.contributor.authorOspina Jimenez, Andres Felipe
dc.date.accessioned2024-07-02T20:47:06Z
dc.date.available2024-07-02T20:47:06Z
dc.date.issued2024
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/86351
dc.descriptionilustraciones, diagramas
dc.description.abstractEl Virus de Influenza A (VIA) en cerdos ocasiona infección respiratoria y se asocia al Complejo Respiratorio Porcino, generando impacto económico y sanitario. En Colombia, la limitada información sobre el VIA en cerdos ha llevado al uso de cepas de referencia internacional en pruebas de diagnóstico serológico. La representatividad de dichas cepas en el contexto colombiano es incierta, lo que afecta la precisión del diagnóstico nacional. Por lo tanto, el objetivo del presente estudio fue caracterizar molecular y antigénicamente VIA porcinos presentes en el país, elegir cepas representativas y verificar su utilidad como antígenos en pruebas serológicas. A través de aproximaciones basadas en secuencia y diversas metodologías moleculares, se caracterizaron 38 VIA provenientes de ocho regiones del país, detectados entre 2008 – 2021. Se eligieron siete candidatos virales, los cuales fueron evaluados mediante pruebas de Inhibición de Hemaglutinación (HI). Los resultados obtenidos muestran que en el país existe diversidad filogenética, lo que se evidencia por la identificación del subtipo H1N1 (clados 1A.3.3.2 y 1A.1) y con el reporte por primera vez de virus de los subtipos H1N2 y H3N2. Adicionalmente, se encontraron cinco clústeres antigénicos en el VIA H1 y se reconoció el H3 como una nueva variante genética y antigénica. Los siete candidatos elegidos permitieron una mejor detección de anticuerpos con respecto a las cepas de referencia utilizadas hasta el momento en el país, mostrando buena repetibilidad en la ejecución de la prueba de HI. A través de asociaciones estadísticas se logró reducir el número de candidatos propuestos a cuatro, los cuales pueden ser potencialmente usados como antígenos de referencia en las pruebas serológicas para VIA en cerdos en el país. (Texto tomado de la fuente).
dc.description.abstractInfluenza A Virus (IAV) in pigs causes respiratory infections and is associated to the Porcine Respiratory Disease Complex, accounting for economical loses and sanitary issues. In Colombia, knowledge about swine IAV is scarce. This has led to the implementation of international reference strains for serological assays. Representativity of these strains in the Colombian context is unknown affecting the national diagnostic capacity. Therefore, this study aimed the molecular and antigenic characterization of swine IAV in the county, the selection of representative strains, and the assessment of their value as antigens for serological assays. 38 IAV from eight regions of the country detected between 2008 – 2021 were characterized through sequence-based approaches. Seven candidates were selected for serological evaluation using the Hemagglutination Assay (HI). The results showed that there is a significant phylogenetic diversity in the country. This is supported by the recognition of the H1N1 subtype (clades: 1A.3.3.2 and 1A.1) and the identification for the first time of the H1N2 and H3N2 virus subtypes. Five antigenic clusters were recognized in the IAV H1 subtype as well as one in the H3 subtype representing a novel genetic and phylogenetic variant. The seven selected candidates allowed a higher antibody detection than the reference strains used until now in the country and they exhibited good repeatability among performs of the HI assay. Based on statistical associations the number of proposed candidates could be reduced to four. These candidates can potentially be included in serological assays in the country.
dc.format.extentxviii, 189 páginas
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.publisherUniversidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.ddc630 - Agricultura y tecnologías relacionadas::632 - Lesiones, enfermedades, plagas vegetales
dc.titleEvaluación y análisis antigénico de virus de campo como candidatos para la actualización del diagnóstico serológico de Influenza en cerdos en Colombia
dc.typeTrabajo de grado - Maestría
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Medicina Veterinaria y de Zootecnia - Maestría en Salud y Producción Animal
dc.description.notesTexto en inglés y español
dc.contributor.researchgroupMicrobiología y Epidemiología
dc.coverage.countryColombia
dc.coverage.tgnhttp://vocab.getty.edu/page/tgn/1000050
dc.description.degreelevelMaestría
dc.description.degreenameMagíster en Salud Animal o Magíster en Producción Animal
dc.description.researchareaMicrobiología e inmunología
dc.identifier.instnameUniversidad Nacional de Colombia
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourlhttps://repositorio.unal.edu.co/
dc.publisher.facultyFacultad de Medicina Veterinaria y de Zootecnia
dc.publisher.placeBogotá, Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
dc.relation.indexedAgrosavia
dc.relation.indexedAgrovoc
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.agrovocVirus de la influenza porcina
dc.subject.agrovocSwine influenzavirus
dc.subject.decsVirus/clasificación
dc.subject.decsVirus/classification
dc.subject.decsAntígenos/análisis
dc.subject.decsAntigens/analysis
dc.subject.proposalInfluenzavirus
dc.subject.proposalAntigenicidad
dc.subject.proposalBioinformática
dc.subject.proposalInfluenza porcina
dc.subject.proposalCartografia antigénica
dc.subject.proposalSwine Influenza
dc.subject.proposalAntigenic characterization
dc.subject.proposalAntigenic cluster
dc.subject.proposalBioinformatics
dc.title.translatedAntigenic analysis of field viruses as candidates for the update of serological diagnosis of Influenza in swine in Colombia
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2
oaire.fundernamePorkcolombia
dcterms.audience.professionaldevelopmentEstudiantes
dcterms.audience.professionaldevelopmentInvestigadores
dcterms.audience.professionaldevelopmentPúblico general
dc.contributor.orcid0000-0003-2836-7923
dc.contributor.cvlacAndres Felipe Ospina [0001884053]


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