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Evaluation of conductive nanofillers addition in scaffolds for myocardial tissue engineering application

dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.contributor.advisorClavijo Grimaldo, Aleida Dianney
dc.contributor.authorMuñoz González, Ana María
dc.date.accessioned2024-07-04T19:58:01Z
dc.date.available2024-07-04T19:58:01Z
dc.date.issued2024-06-30
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/86396
dc.descriptionilustraciones, diagramas, fotografías
dc.description.abstractThis thesis explores the design, fabrication, and of polymeric nanofiber scaffolds with electroconductive nanofillers for cardiac tissue engineering, focusing on myocardial tissue repair through differentiated incorporation of graphene and polypyrrole (PPy) into polycaprolactone (PCL) matrices via electrospinning. The work aims to establish fabrication parameters and assess the morphological, mechanical, chemical, electrical and biocompatibility properties of the scaffolds, with the goal of selecting those that offer optimal theorical electromechanical coupling with myocardial tissue. Two strategies are distinguished: one focused on scaffolds doped with graphene, which show improvements in structural uniformity and mechanical properties, and another on scaffolds enriched with PPy, noted for their significant electrical conductivity. Both strategies present specific advantages, such as enhanced hydrophilicity and the promotion of cell adhesion and proliferation, crucial for tissue regeneration. Despite challenges like the uniform dispersion of nanoparticles and matching the mechanical properties to those of native myocardium, the research highlights the potential of in situ polymerization of PPy as a balanced method for achieving scaffolds with optimized electrical properties and biocompatibility.
dc.description.abstractEsta tesis explora el diseño, fabricación y análisis de andamios de nanofibras poliméricas con nanorrellenos electroconductivos para la ingeniería de tejidos cardíacos, centrándose en la reparación del tejido miocárdico mediante la incorporación diferenciada de grafeno y polipirrol (PPy) en matrices de policaprolactona (PCL) a través del electrohilado. El trabajo tiene como objetivo establecer parámetros de fabricación y evaluar las propiedades morfológicas, mecánicas, químicas, eléctricas y de biocompatibilidad de los andamios, con el fin de seleccionar aquellos que ofrezcan un acoplamiento electromecánico teórico óptimo con el tejido miocárdico. Se distinguen dos estrategias: una centrada en andamios dopados con grafeno, que muestran mejoras en la uniformidad estructural y propiedades mecánicas, y otra en andamios enriquecidos con PPy, conocidos por su significativa conductividad eléctrica. Ambas estrategias presentan ventajas específicas, como la mejora de la hidrofilicidad y la promoción de la adhesión y proliferación celular, cruciales para la regeneración del tejido. A pesar de desafíos como la dispersión uniforme de nanopartículas y la correspondencia de las propiedades mecánicas con las del miocardio nativo, la investigación resalta el potencial de la polimerización in situ de PPy como un método equilibrado para lograr andamios con propiedades eléctricas y biocompatibilidad optimizadas. (Texto tomado de la fuente).
dc.format.extentxv, 201 páginas
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherUniversidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleEvaluation of conductive nanofillers addition in scaffolds for myocardial tissue engineering application
dc.typeTrabajo de grado - Doctorado
dc.type.driverinfo:eu-repo/semantics/doctoralThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Ingeniería - Doctorado en Ingeniería - Ciencia y Tecnología de Materiales
dc.contributor.researchgroupBiomecánica
dc.description.degreelevelDoctorado
dc.description.degreenameDoctor en Ingeniería
dc.description.researchareaNanomateriales e ingeniería tisular
dc.identifier.instnameUniversidad Nacional de Colombia
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourlhttps://repositorio.unal.edu.co/
dc.publisher.facultyFacultad de Ingeniería
dc.publisher.placeBogotá, Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.decsMateriales Biocompatibles/análisis
dc.subject.decsBiocompatible Materials/analysis
dc.subject.decsIngeniería de Tejidos/métodos
dc.subject.decsTissue Engineering/methods
dc.subject.decsMiocardio/patología
dc.subject.decsMyocardium/pathology
dc.subject.proposalElectrospinning
dc.subject.proposalNanofiller
dc.subject.proposalElectroconductive
dc.subject.proposalPolycaprolactone
dc.subject.proposalPolypyrrole
dc.subject.proposalGraphene
dc.subject.proposalScaffold
dc.subject.proposalTissue engineering
dc.subject.proposalElectrohilado
dc.subject.proposalRelleno conductor
dc.subject.proposalNanorelleno
dc.subject.proposalPolicaprolactona
dc.subject.proposalPolipirrol
dc.subject.proposalGrafeno
dc.subject.proposalAndamio
dc.subject.proposalIngeniería de tejidos
dc.title.translatedEvaluación de la adición de nanorrellenos conductores en andamios para aplicaciones de ingeniería de tejidos miocárdicos
dc.type.coarhttp://purl.org/coar/resource_type/c_db06
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.redcolhttp://purl.org/redcol/resource_type/TD
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2
dcterms.audience.professionaldevelopmentInvestigadores
dc.contributor.orcidhttps://orcid.org/0000-0002-3191-9891
dc.contributor.cvlachttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001661109


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