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Serotonina, vitamina D, hábitos alimentarios y actividad física en trastornos funcionales intestinales en un grupo de adultos: estudio de casos - controles (Bogotá 2022-2023)

dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.contributor.advisorPoveda Espinosa, Elpidia
dc.contributor.advisorAgudelo Cañas, Samantha
dc.contributor.authorAhumada Ossa, Laura Marcela
dc.coverage.temporal2022 - 2023
dc.date.accessioned2024-01-22T14:08:19Z
dc.date.available2024-01-22T14:08:19Z
dc.date.issued2023-12-01
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/85385
dc.descriptionilustraciones, diagramas
dc.description.abstractIntroducción: Algunas investigaciones han relacionado niveles de vitamina D más bajos y desregulación serotoninérgica en los trastornos funcionales intestinales (cuyas siglas en inglés son FBD) que surgen de interacciones desordenadas en el eje-intestino-cerebro. Otros factores que pueden asociarse a los FBD son la son la alimentación, la actividad física y las condiciones psicoemocionales. Objetivo: determinar si las concentraciones séricas alteradas de serotonina, vitamina D, los hábitos alimentarios inadecuados relacionados con salud intestinal y el sedentarismo son factores de asociación para el desarrollo de trastornos funcionales intestinales en un grupo de adultos de 18 a 60 años de Bogotá. Metodología: estudio de 87 controles y 79 casos, que correspondieron a personas con diagnóstico de FBD por criterios ROMA IV. Se evaluaron concentraciones de serotonina y 25(OH)D, proteína C reactiva, consumo de fibra, agua, prebióticos y probióticos; actividad física (IPAQ) y estrés, ansiedad y depresión (DASS-21). Resultados: las concentraciones séricas alteradas de serotonina, vitamina D, los hábitos alimentarios inadecuados y el sedentarismo son factores que no se asocian con el desarrollo de FBD en la población de estudio, pero se encontró que el sexo masculino (OR 0,17; IC95% 0,74-0,42, p=0,000*), puntaje global de DASS-21 (OR 1,10; IC95% 1,05-1,15, p=0,000*) y el puntaje del consumo de prebióticos y probióticos (OR 0,94; IC95% 0,89-0,98, p=0,006*) son factores que se asocian con la presencia de FBD. Conclusiones: se identificó una asociación significativa entre la existencia de ansiedad, estrés y depresión con la presencia de FBD. Igualmente, se considera necesario continuar investigando la relación entre el consumo de prebióticos y probióticos y el desarrollo de FBD. (Texto tomado de la fuente)
dc.description.abstractIntroduction: Some research has linked lower vitamin D levels and serotonergic dysregulation in functional bowel disorders (FBD) that arise from disordered interactions in the gut-brain axis. Other factors that may be associated with FBD are diet, physical activity, and psycho-emotional conditions. Objective: to determine whether altered serum concentrations of serotonin, vitamin D, inadequate dietary habits related to intestinal health and a sedentary lifestyle are association factors for the development of functional intestinal disorders in a group of adults aged 18 to 60 years from Bogotá. Methods: study of 87 controls and 79 cases, which corresponded to people diagnosed with FBD according to ROME IV criteria. Serotonin and 25(OH)D concentrations, C-reactive protein, fiber consumption, water, prebiotics, and probiotics were evaluated; physical activity (IPAQ) and stress, anxiety and depression (DASS-21). Results: altered serum concentrations of serotonin, vitamin D, inadequate eating habits and a sedentary lifestyle are factors that are not associated with the development of FBD in the study population, but it was found that male sex (OR 0.17; CI95 % 0.74-0.42, p=0.000*), DASS-21 global score (OR 1.10; 95% CI 1.05-1.15, p=0.000*) and the prebiotic and probiotics consumption score (OR 0.94; 95% CI 0.89-0.98, p=0.006*) are factors that are associated with the presence of FBD. Conclusions: a significant association was identified between the existence of anxiety, stress, and depression with the presence of FBD. Likewise, it is considered necessary to continue investigating the relationship between the consumption of prebiotics and probiotics and the development of FBD.
dc.format.extent132 páginas
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.publisherUniversidad Nacional de Colombia
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc610 - Medicina y salud::612 - Fisiología humana
dc.titleSerotonina, vitamina D, hábitos alimentarios y actividad física en trastornos funcionales intestinales en un grupo de adultos: estudio de casos - controles (Bogotá 2022-2023)
dc.typeTrabajo de grado - Maestría
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.publisher.programBogotá - Medicina - Maestría en Fisiología
dc.contributor.researchgroupAlimentación y Nutrición Humana
dc.coverage.cityBogotá
dc.description.degreelevelMaestría
dc.description.degreenameMagíster en Fisiología
dc.description.methodsEstudio de 87 controles y 79 casos, que correspondieron a personas con diagnóstico de FBD por criterios ROMA IV. Se evaluaron concentraciones de serotonina y 25(OH)D, proteína C reactiva, consumo de fibra, agua, prebióticos y probióticos; actividad física (IPAQ) y estrés, ansiedad y depresión (DASS-21).
dc.description.researchareaPrevención y tratamiento de las enfermedades crónicas
dc.identifier.instnameUniversidad Nacional de Colombia
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombia
dc.identifier.repourlhttps://repositorio.unal.edu.co/
dc.publisher.facultyFacultad de Medicina
dc.publisher.placeBogotá,Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotá
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.subject.decsEnfermedades Intestinales
dc.subject.decsIntestinal Diseases
dc.subject.decsEstilo de Vida Saludable
dc.subject.decsHealthy Lifestyle
dc.subject.proposalTrastornos funcionales intestinales
dc.subject.proposalVitamina D
dc.subject.proposalSerotonina
dc.subject.proposalEje intestino-cerebro
dc.subject.proposalEstilos de vida saludable
dc.subject.proposalFunctional bowel disorders
dc.subject.proposalVitamin D
dc.subject.proposalSerotonin
dc.subject.proposalGut-brain axis
dc.subject.proposalHealthy lifestyles
dc.title.translatedSerotonin, vitamin D, eating habits and physical activity in functional bowel disorders in a group of adults: case-control study (Bogotá-2022-2023)
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2
dcterms.audience.professionaldevelopmentEstudiantes
dcterms.audience.professionaldevelopmentInvestigadores
dcterms.audience.professionaldevelopmentMaestros
dc.contributor.orcidAhumada Ossa, Laura Marcela [0000-0002-6028-0468]
dc.contributor.cvlacAhumada Ossa, Laura Marcela [https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001786244#red_identificadores]
dc.contributor.researchgateAhumada Ossa, Laura Marcela [https://www.researchgate.net/profile/Laura-M-Ahumada-Ossa]
dc.contributor.googlescholarAhumada Ossa, Laura Marcela [https://scholar.google.com/citations?user=HzLUahsAAAAJ&hl=es]


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