Variabilidad en genes candidatos y su asociación con la respuesta de defensa a la bacteriosis vascular en yuca (Manihot esculenta Crantz)

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dc.contributor.advisorSoto Sedano, Johana Carolinaspa
dc.contributor.advisorLópez Carrascal, Camilo Ernestospa
dc.contributor.authorIshikawa García, Emilispa
dc.contributor.orcidIshikawa, Emili [0000000195549300]spa
dc.contributor.refereeChacón Sanchéz, Maria Isabelspa
dc.contributor.refereeBernal Jiménez, Adrianaspa
dc.contributor.researchgroupManihot Biotecspa
dc.date.accessioned2025-09-16T01:42:27Z
dc.date.available2025-09-16T01:42:27Z
dc.date.issued2025-08-22
dc.descriptionilustraciones, diagramasspa
dc.description.abstractLa yuca, Manihot esculenta Crantz, es un cultivo indispensable para la seguridad alimentaria en países del trópico. Su producción se ve amenazada por diversas enfermedades, de las cuales la bacteriosis vascular de la yuca (CBB por Cassava Bacterial Blight) es una de las más limitantes. La CBB es causada por Xanthomonas phaseoli pv. manihotis (Xpm), un patógeno presente en todos los países donde se cultiva yuca. La siembra de materiales resistentes es la estrategia más efectiva para la mitigación de la enfermedad. Por ende, es necesaria la exploración y profundización de las bases genéticas responsables de la resistencia. El propósito de este trabajo fue asociar la variabilidad alélica en genes candidatos (GCs) de resistencia con la respuesta fenotípica frente a la infección por Xpm, empleando un enfoque de mapeo por asociación. El panel de estudio estuvo compuesto de 107 cultivares (genotipos) de yuca colectados en Colombia, junto a 60444, un cultivar de origen africano previamente reportado como susceptible. Los GCs fueron seleccionados con base en una búsqueda de literatura enfocada en Xpm681, la cual incluyó a) genes con expresión diferencial entre plantas inoculadas vs no inoculadas y b) genes que co-localizan con loci de caracteres cuantitativos (QTLs, Quantitative Trait Loci) asociados con resistencia a CBB. Los polimorfismos de nucleótido único (SNPs, Single Nucleotide Polymorphisms) dentro de estos genes fueron identificados mediante genotipificación por secuenciación (GBS por Genotyping By Sequencing). Para evaluar la asociación estadística entre los SNPs y la respuesta fenotípica, se empleó un modelo lineal mixto (MLM) que incorporó la estructura poblacional y la relación de parentesco. Cinco SNPs ubicados en cinco GCs estuvieron significativamente asociados con la resistencia (LOD > 3.0). De los GC asociados, se destacan especialmente los genes Manes.15G053800 y Manes.16G020100, que codifican una proteína con dominio SWI/SNF y un transportador de azúcar, relacionados previamente con resistencia en otros patosistemas. (Texto tomado de la fuente).spa
dc.description.abstractCassava (Manihot esculenta Crantz) is an essential crop for food security in tropical countries. Its production is threatened by various diseases, among which Cassava Bacterial Blight (CBB) is one of the most limiting. CBB is caused by Xanthomonas phaseoli pv. manihotis (Xpm), a pathogen presents in all countries where cassava is cultivated. Planting resistant varieties is the most effective strategy for disease mitigation. Therefore, exploring and deepening the understanding of the genetic basis underlying resistance is necessary. This study aimed to associate allelic variability in candidate resistance genes (CGs) with phenotypic response to Xpm infection, using an association mapping approach. The panel of genotypes included 107 cassava cultivars collected in Colombia, along with 60444, a cultivar of African origin previously reported as susceptible. CGs were selected based on a literature review focused on Xpm681, which included: a) genes with differential expression between inoculated and non-inoculated plants and b) genes located in quantitative trait loci (QTLs) associated with resistance to CBB. Single-nucleotide polymorphisms (SNPs) within these genes were identified using genotyping-by-sequencing (GBS). To evaluate the statistical association between SNPs and phenotypic response, a mixed linear model (MLM) was employed, incorporating population structure and kinship. Five SNPs located in five CGs were significantly associated with resistance (LOD > 3.0). Among the associated GCs, the genes Manes.15G053800 and Manes.16G020100—which encode a SWI/SNF domain-containing protein and a sugar transporter, respectively—stand out for their prior association with resistance in other pathosystems.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Ciencias Agrariasspa
dc.description.researchareaGenética y fitomejoramientospa
dc.description.sponsorshipFundación para la promoción de la investigación y la tecnología (Banco de la República).spa
dc.format.extentx, 61 páginasspa
dc.format.mimetypeapplication/pdf
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/88787
dc.language.isospa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.departmentDepartamento de Agronomíaspa
dc.publisher.facultyFacultad de Ciencias Agrariasspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Ciencias Agrarias - Maestría en Ciencias Agrariasspa
dc.relation.indexedAgrosaviaspa
dc.relation.indexedAgrovocspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.licenseAtribución-NoComercial 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subject.agrovocAlelismospa
dc.subject.agrovocallelismeng
dc.subject.agrovocMecanismo de defensaspa
dc.subject.agrovocdefence mechanismseng
dc.subject.agrovocEnfermedad bacterianaspa
dc.subject.agrovocbacterial diseaseseng
dc.subject.ddc570 - Biología::576 - Genética y evoluciónspa
dc.subject.proposalResistencia cuantitativaspa
dc.subject.proposalCBBspa
dc.subject.proposalSNPspa
dc.subject.proposalModelo lineal mixtospa
dc.subject.proposalQuantitative resistanceeng
dc.subject.proposalCBBeng
dc.subject.proposalSNPeng
dc.subject.proposalMixed linear modeleng
dc.titleVariabilidad en genes candidatos y su asociación con la respuesta de defensa a la bacteriosis vascular en yuca (Manihot esculenta Crantz)spa
dc.title.translatedAllelic variability in candidate genes and its association with the defense response to Cassava Bacterial Blighteng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdcc
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dcterms.audience.professionaldevelopmentEstudiantesspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2

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