Microbioma y parámetros intestinales, metabólicos y zootécnicos de pollos alimentados con aceite esencial de orégano (Lippia origanoides) en un modelo de inflamación intestinal in vivo

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dc.contributor.advisorParra Suescún, Jaime Eduardo
dc.contributor.advisorLópez Herrera, Albeiro
dc.contributor.authorMadrid Garcés, Tomás Antonio
dc.date.accessioned2021-06-02T19:03:35Z
dc.date.available2021-06-02T19:03:35Z
dc.date.issued2020
dc.descriptionTesis doctoral.spa
dc.description.abstractLa producción agropecuaria actual es muy exigente en aspectos de calidad que se traduce en alimentos más seguros para los consumidores. En la avicultura se usan los antibióticos de manera profiláctica, conocidos como Antibióticos Promotores de Crecimiento (APC) con excelentes resultados productivos, pero con grandes dudas frente al tema de seguridad alimentaria por la proliferación de resistencia antimicrobiona y la llegada de estos microrganismos a la cadena alimenticia. Los fitobióticos se han presentado como una de las alternativas más efectivas a la hora de reemplazar los APC, dentro de estos extractos de plantas se encuentra el Aceite esencial de oregano (AEO) de Lippia origanoides, que viene demostrando sus propiedades en diferentes aspectos dentro de la producción avícola. El presente trabajo pretende estudiar el efecto de la adición de AEO sobre variables productivas, metabólicas, morfometría digestiva, células caliciformes, expresión molecular de enzimas y transportadores, y microbiota intestinal de pollos en un modelo de inflamación in vivo logrado mediante LPS de e coli. Se logró evidenciar que la adición de AEO mejora las variables zootécnicas (Ganancia acumulada de peso), metabolitos sanguíneos (glucosa, fosforo, calcio, colesterol, triglicéridos), morfometría digestiva (altura de vellosidades y profundad de criptas), células caliciformes (tipo de tinción), expresión molecular de enzimas y transportadores (MgA: maltasa-glucoamilasa; SI: sacarasa-isomaltasa; SGLT-1: sodium-glucose transporter; GLUT-5: glucose transporter-5; GLUT-2: glucose transporter-2) y modula positivamente la microbiota intestinal de pollos de engorde en un modelo inflación in vivo. El AEO se proyecta como un promotor nutricional de crecimiento con capacidad de reemplazar los APC.spa
dc.description.abstractCurrent agricultural production is very demanding in terms of quality, which translates into safer food for consumers. In poultry, antibiotics are used prophylactically, known as Growth Promoting Antibiotics (GAP) with excellent productive results, but with great doubts regarding the issue of food safety due to the proliferation of antimicrobial resistance and the arrival of these microorganisms to the chain food. Phytobiotics have been presented as one of the most effective alternatives when it comes to replacing GAP, within these plant extracts is the Essential Oil of oregano (AEO) from Lippia origanoides, which has been demonstrating its properties in different aspects within poultry production. The present study aims to study the effect of the addition of AEO on productive and metabolic variables, digestive morphometry, goblet cells, molecular expression of enzymes and transporters, and intestinal microbiota of chickens in an in vivo model of inflammation achieved by e coli LPS. It was possible to show that the addition of AEO improves the zootechnical variables (accumulated weight gain), blood metabolites (glucose, phosphorus, calcium, cholesterol, triglycerides), digestive morphometry (height of villi and depth of crypts), goblet cells (type of staining), molecular expression of enzymes and transporters (MgA: maltaseglucoamylase; SI: sucrase-isomaltase; SGLT-1: sodium-glucose transporter; GLUT-5: glucose transporter-5; GLUT-2: glucose transporter-2) and positively modulates the gut microbiota of broilers in an in vivo inflation model. AEO is projected as a nutritional growth promoter with the ability to replace GAPseng
dc.description.degreelevelDoctoradospa
dc.description.degreenameDoctor en Biotecnologíaspa
dc.description.researchareaBiotecnología aplicada a la producción animal: microbioma intestinal.spa
dc.description.sponsorshipConvocatoria 757 de Colciencias operada por Colfuturo.spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/79600
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombia - Sede Medellínspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Medellínspa
dc.publisher.departmentEscuela de biocienciasspa
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.placeMedellínspa
dc.publisher.programMedellín - Ciencias - Doctorado en Biotecnologíaspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subject.ddc660 - Ingeniería químicaspa
dc.subject.lembExtractos vegetales
dc.subject.lembIndustria avícola
dc.subject.proposalAviculturaspa
dc.subject.proposalFitobioticosspa
dc.subject.proposalMicrobiomaspa
dc.subject.proposalDysbiosiseng
dc.subject.proposalGrowth promoterseng
dc.subject.proposalPhytobioticseng
dc.subject.proposalAntibióticos Promotores de Crecimientozho
dc.subject.proposalGrowth Promoting Antibioticseng
dc.subject.proposalAceite esencial de oreganospa
dc.subject.proposalOregano essential oileng
dc.titleMicrobioma y parámetros intestinales, metabólicos y zootécnicos de pollos alimentados con aceite esencial de orégano (Lippia origanoides) en un modelo de inflamación intestinal in vivospa
dc.title.translatedMicrobiome and intestinal, metabolic and zootechnical parameters of chickens fed with oregano essential oil (Lippia origanoides) in a model of intestinal inflammation in vivoeng
dc.typeTrabajo de grado - Doctoradospa
dc.type.coarhttp://purl.org/coar/resource_type/c_db06spa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/doctoralThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TDspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.awardtitle“Microbioma y parámetros intestinales, metabólicos y zootécnicos de pollos alimentados con aceite esencial de orégano (Lippia origanoides) en un modelo de inflamación intestinal in vivo”spa
oaire.fundernameColcienciasspa

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