Interacción de la estimulación somatosensorial periférica y cortical sobre el procesamiento de la información somatosensorial en la corteza motora primaria de las vibrisas en ratas

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dc.contributor.advisorMúnera Galarza, Francisco Alejandro
dc.contributor.authorNiño Hernández, Angélica Beatriz
dc.contributor.cvlacAngelica Beatriz Niñospa
dc.contributor.researchgroupNeurofisiología comportamentalspa
dc.date.accessioned2024-07-31T16:51:40Z
dc.date.available2024-07-31T16:51:40Z
dc.date.issued2024
dc.descriptionilustraciones, diagramasspa
dc.description.abstractEl sistema de las vibrisas en roedores constituye un modelo de investigación de gran importancia para entender el proceso de integración sensoriomotora. Esto se debe a su bien definida representación somatotópica en la corteza somatosensorial de los barriles (S1b) y a la extensa investigación sobre las vías de transducción de estímulos táctiles a señales eléctricas. En este trabajo, se estudió la interacción de la estimulación somatosensorial periférica y cortical sobre el procesamiento de esta información en la corteza motora primaria de las vibrisas (vM1). Para ello, se emplearon protocolos de pares de pulsos, pre-estimulación y se evaluó el comportamiento oscilatorio en el dominio de tiempo y frecuencia. En este contexto, se amplió la caracterización de la respuesta en vM1 y S1b ante estímulos únicos en el parche de vibrisas (WP). Además, se caracterizó por primera vez en ratas la respuesta provocada en vM1 ante estimulación en S1b. Los hallazgos indican que la información somatosensorial de las vibrisas llega simultáneamente a S1b y vM1. Mediante protocolos de pares de pulsos en WP, se evidenció activación sostenida de circuitos inhibidores en vM1 y S1b por parte de las entradas tálamo-corticales, asociada con oscilaciones gamma. Al administrar pares de pulsos en S1b, se evidenció la naturaleza monosináptica de las proyecciones desde S1b a vM1, que tienen un efecto temprano excitador y uno tardío inhibidor. Finalmente, para evaluar las interacciones funcionales de vM1 con S1b, se utilizó el protocolo de pre-estimulación. La estimulación en S1b antecediendo la estimulación en WP, desfacilitó las oscilaciones lentas del potencial provocado en vM1 en dos ventanas de tiempo asociado con una actividad en la banda theta y gamma alta. Por otro lado, la administración de estímulos en WP antecediendo la estimulación en S1b, facilitó las oscilaciones lentas del potencial provocado en vM1 a intervalos entre estímulos (IEEs) cortos, relacionado con la coincidencia de entradas excitadoras cortico-corticales desde S1b con las entradas intracorticales de vM1 procedentes de la activación tálamo-cortical. Sin embargo, en IEEs mayores, esta pre-estimulación incrementa la actividad inhibitoria en la banda theta y gamma. Este estudio complementa el conocimiento previo sobre la respuesta provocada en vM1 ante estimulación periférica y revela, por primera vez en ratas, la caracterización de la respuesta provocada en vM1 ante estimulación en S1b mediante un enfoque electrofisiológico y de análisis espectral en el dominio del tiempo y frecuencia (Texto tomado de la fuente).spa
dc.description.abstractThe whisker system in rodents constitutes a research model of great importance for understanding the process of sensorimotor integration. Its significance lies in the well-defined somatotopic representation in the barrel cortex (S1b) and to the extensive research on the transduction pathways of tactile stimuli to electrical signals. In this study, the interaction of peripheral and cortical somatosensory stimulation on the processing of this information in the vibrissal primary motor cortex (vM1) was examined. For this aim, paired-pulse, pre-stimulation protocols and oscillatory behavior in the time and frequency domain were used. In this context, the characterization of the response in vM1 and S1b to single stimuli in the whisker pad (WP) was extended. In addition, the response evoked in vM1 to stimulation in S1b was characterized for the first time in rats. The findings indicate that somatosensory information from the whiskers simultaneously reaches both S1b and vM1. Using paired-pulse protocols in WP, sustained activation of inhibitory circuits in vM1 and S1b by thalamocortical inputs, associated with gamma oscillations, was evidenced. When administering paired pulses in S1b, the monosynaptic nature of the projections from S1b to vM1, which have an early excitatory and a late inhibitory effect, was evidenced. Finally, to evaluate the functional interactions of vM1 with S1b, the pre-stimulation protocol was used. S1b stimulation preceding WP stimulation defacilitated slow oscillations of the evoked potential in vM1 in two-time windows associated with theta and high gamma activity. On the other hand, WP stimulus preceding S1b stimulation facilitated slow oscillations of the evoked potential in vM1 at short interstimulus intervals (ISIs), related to the coincidence of cortico-cortical excitatory inputs from S1b and intracortical inputs vM1 from thalamocortical activation. However, at longer ISIs, this pre-stimulation increased inhibitory activity in the theta and gamma bands. This study complements prior knowledge on the evoked response in vM1 to peripheral stimulation and reveals, for the first time in rats, the characterization of the evoked response in vM1 to stimulation in S1b by an electrophysiological approach and spectral analysis in the time and frequency domain.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagister en Ciencias - Biologíaspa
dc.description.methodsSe emplearon nueve ratas macho Wistar adultas, con un peso entre 300 g y 400 g. Estos animales fueron obtenidos del Bioterio Central de la Universidad Nacional de Colombia, sede Bogotá, en la Facultad de Medicina Veterinaria y Zootecnia. En el bioterio, los sujetos experimentales fueron mantenidos en una sala con atenuación de ruido, con control de humedad (40 ± 5%) y temperatura (20 ± 1 °C), con ciclo de luz / oscuridad de 12 horas y con suministro de alimento y agua fresca potable ad libitum. Minutos antes de iniciar cada experimento, el animal fue trasladado al laboratorio de Neurofisiología Comportamental de la Facultad de Medicina de la Universidad Nacional de Colombia. Para ello, se utilizaron cajas de policarbonato (38 x 32 x 18 cm) con una capa de viruta de madera en el fondo y cubierta de una tela negra para evitar estrés del animal durante su traslado.spa
dc.description.researchareaFisiología del control motor facialspa
dc.format.extent96 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/86667
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Ciencias - Maestría en Ciencias - Biologíaspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseReconocimiento 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/spa
dc.subject.ddc570 - Biología::571 - Fisiología y temas relacionadosspa
dc.subject.ddc570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animalesspa
dc.subject.lembRECEPTORES SENSORIALESspa
dc.subject.lembSensory receptorseng
dc.subject.lembLOBULO PARIETALspa
dc.subject.lembParietal lobeseng
dc.subject.lembGENERALIZACION DEL ESTIMULOspa
dc.subject.lembStimulus generalizationeng
dc.subject.proposalSistema de las vibrisasspa
dc.subject.proposalCorteza motora de las vibrisasspa
dc.subject.proposalCorteza de los barrilesspa
dc.subject.proposalIntegración sensoriomotoraspa
dc.subject.proposalWhisker systemeng
dc.subject.proposalVibrissal motor cortexeng
dc.subject.proposalBarrel cortexeng
dc.subject.proposalSensorimotor integrationeng
dc.titleInteracción de la estimulación somatosensorial periférica y cortical sobre el procesamiento de la información somatosensorial en la corteza motora primaria de las vibrisas en ratasspa
dc.title.translatedInteraction of peripheral and cortical somatosensory stimulation on somatosensory information processing in the vibrissal primary motor cortex in ratseng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

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