Análisis de propiedades fisicoquímicas y mecánicas de envases de soluciones salinas intravenosas sometidos a procesos de calentamiento vía microondas

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dc.contributor.advisorSierra Ávila, César Augusto
dc.contributor.advisorMéndez Córdoba, Luis Carlos
dc.contributor.authorPérez Martínez, Vanesa
dc.contributor.researchgroupGrupo de Investigación en Macromoléculasspa
dc.contributor.researchgroupGrupo de Investigación en Ciencia, Ingeniería y Salud - Gicis.spa
dc.date.accessioned2023-07-27T15:23:03Z
dc.date.available2023-07-27T15:23:03Z
dc.date.issued2022-06-09
dc.descriptionilustraciones, fotografías, gráficas, tablasspa
dc.description.abstractPara el área de la salud, en la distribución, almacenamiento y transporte de medicamentos, existen diversos envases poliméricos comercializados en Colombia. Para el caso específico del envase de soluciones salinas intravenosas, el material polimérico más utilizado es el poli cloruro de vinilo (PVC). Desafortunadamente, no hay información clara sobre la composición exacta de estos envases, ni los efectos sobre el material y la solución salina al exponer estos a calentamiento por microondas, proceso normalmente usado para acondicionar el líquido antes de suministrarlo a un paciente. Por tal motivo, envases de soluciones salinas comercializados en Colombia se caracterizaron por espectroscopia infrarroja (IR), termogravimetría (TGA), calorimetría diferencial de barrido (DSC), prueba de esfuerzo-deformación y cromatografía de gases acoplada a espectrómetro de masas (GC-MS). Caracterizaciones realizadas antes y después de someter el empaque junto a su solución salina a calentamiento con microondas. Los resultados indican que el material polimérico en el envase es PVC con un alto contenido de DEP como plastificante. Adicionalmente, y teniendo en cuenta que los resultados muestran que el plastificante está migrando desde el empaque hacia la solución y al ser estas soluciones empleadas en mujeres en estado de embarazo, se generó un protocolo adecuado de calentamiento para ser implementado en el instituto materno infantil de la ciudad de Bogotá. Por último, se planteó una alternativa de envase libre de plastificante con un material biodegradable, el cual es poli 3-hidroxibutirato-co-3-hidroxivalerato (PHBV). (Texto tomado de la fuente)spa
dc.description.abstractFor the health sector, in the distribution, storage and transport of medicines, there are various options of polymeric packaging available in Colombia. For the specific case of intravenous saline solution containers, the most commonly used polymeric material is polyvinyl chloride (PVC). Unfortunately, there is no clear information on the exact composition of these packaging materials, nor the effects on the material and saline when exposed to microwave heating, a process typically used to condition liquid before administration to a patient. . For this reason, the saline solution containers marketed in Colombia were characterized by infrared spectroscopy (IR), thermogravimetry (TGA), differential scanning calorimetry (DSC), stress-strain tests and gas chromatography-mass spectrometry (GC-MS). The characterizations were carried out before and after submitting the container and the saline solution to microwave heating. The results indicate that the polymeric material of the packaging is PVC with a high content of DEP as a plasticizer. Additionally, considering that the results show that the plasticizer is migrating from the container to the solution and since these solutions used in pregnant women, an adequate heating protocol developed to be implemented in the maternal and child institute of the city of Bogota. Finally, an alternative packaging option proposed that does not contain plasticizers and is made from a biodegradable material called poly 3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV).eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Ingeniería - Materiales y Procesosspa
dc.description.researchareaMateriales poliméricos usados en la industria médicaspa
dc.format.extent127 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/84304
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Ingenieríaspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Ingeniería - Maestría en Ingeniería - Materiales y Procesosspa
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dc.relation.referencesBoufarguine, M.; Guinault, A.; Miquelard-Garnier, G.; Sollogoub, C. PLA/PHBV Films with Improved Mechanical and Gas Barrier Properties. Macromol Mater Eng 2013, 298 (10), 1065–1073. https://doi.org/10.1002/mame.201200285spa
dc.rightsDerechos reservados al autor, 2023spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subject.ddc620 - Ingeniería y operaciones afines::621 - Física aplicadaspa
dc.subject.decsSolución Salinaspa
dc.subject.decsSaline Solutioneng
dc.subject.decsAdministración Intravenosaspa
dc.subject.decsAdministration, Intravenouseng
dc.subject.proposalEnvasespa
dc.subject.proposalSolución intravenosaspa
dc.subject.proposalPVCspa
dc.subject.proposalDEPspa
dc.subject.proposalMicroondasspa
dc.subject.proposalMujeres en embarazospa
dc.subject.proposalPHBVspa
dc.subject.proposalContainereng
dc.subject.proposalIntravenous saline solutioneng
dc.subject.proposalPVCeng
dc.subject.proposalDEPeng
dc.subject.proposalMicrowaveeng
dc.subject.proposalPregnant womeneng
dc.subject.proposalPHBVeng
dc.titleAnálisis de propiedades fisicoquímicas y mecánicas de envases de soluciones salinas intravenosas sometidos a procesos de calentamiento vía microondasspa
dc.title.translatedAnalysis of physicochemical and mechanical properties of intravenous saline solution containers subjected to microwave heating processeseng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

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