Simulation of chemotactic migration of a crawling cell by finite elements in a two-dimensional framework

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dc.contributor.advisorGarzón Alvarado, Diego Alexánder
dc.contributor.advisorMadzvamuse, Anotida
dc.contributor.authorHernández Aristizábal, David
dc.contributor.researchgroupGNUM - Grupo de Modelado y Métodos Numericos en Ingenieríaspa
dc.date.accessioned2021-05-20T17:59:51Z
dc.date.available2021-05-20T17:59:51Z
dc.date.issued2021
dc.descriptionilustraciones a color, tablasspa
dc.description.abstractLa migración celular es un proceso presente en todas las etapas de la vida que es accionado principalmente por la dinámica del citoesqueleto de actina. Los trabajos experimentales y computacionales han sido clave para elucidar los mecanismos presentes en este fenómeno. Los primeros permiten modelar interacciones intra y extracelulares de forma realística y los segundos permiten aislar y analizar tales interacciones. En este trabajo se presenta un marco computacional capaz de copiar algunas características de la migración celular en dos dimensiones. Se consideran dinámicas membranales y citosólicas que pueden ser activadas o modificadas por señales externas. Los resultados muestran que la implementación computacional es capaz de reproducir las siguientes características fundamentales: (i) polarización en la membrana, (ii) polarización en el citosol y (iii) protusiones dependientes de actina.spa
dc.description.abstractCell migration is a process ubiquitous in life that is mainly trigger by the dynamics of the actin cytoskeleton. Experimental and computational works have been key to elucidate the mechanisms underlying this phenomenon. The former allow modelling realistic interactions both at the intra and extracellular level while the later allow the isolation and analysis of such interactions. Here, we present a computational framework able to mimic some two-dimensional cell-migration features considering membrane and cytosolic activities that may be triggered by external cues. The results show that the computational implementation is able to deal with the following fundamental characteristics: (i) membrane polarisation, (ii) cytosolic polarisation, and (iii) actin-dependent protrusions.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Ingeniería - Ingeniería Mecánicaspa
dc.description.researchareaModelación computacionalspa
dc.format.extent1 recurso en línea (77 páginas)spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/79543
dc.language.isoengspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Ingenieríaspa
dc.publisher.placeBogotáspa
dc.publisher.programBogotá - Ingeniería - Maestría en Ingeniería - Ingeniería Mecánicaspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/spa
dc.subject.ddc620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingenieríaspa
dc.subject.decsQuimiotaxis
dc.subject.decsChemotaxis
dc.subject.decsCélulas Quimiorreceptoras
dc.subject.decsChemoreceptor Cells
dc.subject.otherSimulación (Informática)
dc.subject.otherComputer simulation
dc.subject.proposalcomputational cell migrationeng
dc.subject.proposalESFEMeng
dc.subject.proposalMoving mesheng
dc.subject.proposalbulk-surface PDEeng
dc.subject.proposalMigración celular computacionalspa
dc.subject.proposalMétodo de elementos finitos en superficies en evoluciónspa
dc.subject.proposalMalla en movimientospa
dc.subject.proposalEDP de bulto y superficiespa
dc.titleSimulation of chemotactic migration of a crawling cell by finite elements in a two-dimensional frameworkeng
dc.title.translatedSimulación del movimiento tipo arrastrado de una célula en migración tipo quimiotáctica por elementos finitos en un dominio bidimensionalspa
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

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