Estudio de la formación de azaciclofanos derivados de L-Tirosina y su interacción con zinc

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dc.contributor.advisorQuevedo Pastor, Ariel Rodolfospa
dc.contributor.authorCháves Sánchez, Sebastián Camilospa
dc.contributor.cvlacChaves, Sebastian [0001703007]spa
dc.contributor.googlescholarChaves, Sebastián [e2tLfbwAAAAJ]spa
dc.contributor.orcidChaves, Sebastián [0000-0001-7479-7858]spa
dc.contributor.researchgateChaves, Sebastián [Sebastian-Chaves-Sanchez]spa
dc.contributor.researchgroupQuímica Macrocíclicaspa
dc.date.accessioned2024-05-14T20:16:07Z
dc.date.available2024-05-14T20:16:07Z
dc.date.issued2024-04-18
dc.descriptionilustraciones, diagramasspa
dc.description.abstractEn este trabajo se estudió la síntesis de azaciclofanos derivados de L-tirosina empleando la estrategia de síntesis denominada “Síntesis asistida por enlace de hidrógeno”. Los resultados permiten establecer que la estrategia de síntesis permite obtener azaciclofanos pentacíclicos simétricos por reacciones de 2 componentes y asimétricos por reacciones de 3 componentes. Esta estrategia de síntesis permite obtener ciclofanos bencílicos simétricos con sustituyentes sobre el nitrógeno por reacciones de dos componentes y asimétricos por reacción de tres componentes. Cabe mencionar que efectos estéricos e interacciones ácido-base pueden influir en el curso de la reacción para la obtención del producto macrocíclico u oligómeros lineales. Se determino que los azaciclofanos derivados de L-tirosina interactúan con Zn 2+ por la periferia del macrociclo por la parte alifática y que su relación estequiométrica es 1:1 entre el azaciclofano y el metal, con la mayoría de ciclofanos estudiados. (Texto tomado de la fuente).spa
dc.description.abstractIn this work, the synthesis of azacyclophanes derived from L-tyrosine was studied using the synthesis strategy called “Hydrogen bond-assisted synthesis”. The results allow us to establish that the synthesis strategy allows obtaining symmetrical pentacyclic azacyclophanes by 2-component reactions and asymmetric by 3-component reactions. This synthesis strategy allows obtaining symmetrical benzylic cyclophanes with substituents on the nitrogen by two-component reactions and asymmetrical ones by three-component reaction. It is worth mentioning that steric effects and acid-base interactions can influence the course of the reaction to obtain the macrocyclic product or linear oligomers. It was determined that azacyclophanes derived from L-tyrosine interact with Zn2+ at the periphery of the macrocycle on the aliphatic part and that their stoichiometric relationship is 1:1 between azacyclophane and the metal, with the majority of cyclophanes studied.eng
dc.description.degreelevelDoctoradospa
dc.description.degreenameDoctor en Ciencias - Químicaspa
dc.description.researchareaSíntesis orgánicaspa
dc.format.extentxxix, 157 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/86083
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Ciencias - Doctorado en Ciencias - Químicaspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/spa
dc.subject.ddc540 - Química y ciencias afines::547 - Química orgánicaspa
dc.subject.decsTirosina/químicaspa
dc.subject.decsTyrosine/chemistryeng
dc.subject.proposalAzaciclofanosspa
dc.subject.proposalL - tirosinaspa
dc.subject.proposalAzacyclophaneseng
dc.subject.proposalL - tyrosineeng
dc.subject.proposalMannich type reactioneng
dc.subject.proposalhydrogen bondeng
dc.subject.proposalAminaspa
dc.subject.proposalReacción tipo Mannichspa
dc.subject.proposalFormaldehídospa
dc.subject.proposalEnlace de hidrógenospa
dc.subject.proposalAmineeng
dc.subject.proposalFormaldehydeeng
dc.subject.unescoInvestigación químicaspa
dc.subject.unescoChemical researcheng
dc.subject.wikidataMacrociclospa
dc.subject.wikidatamacrocycleeng
dc.titleEstudio de la formación de azaciclofanos derivados de L-Tirosina y su interacción con zincspa
dc.title.translatedStudy of the formation of azacyclophanes derived from L-Tyrosine and its interaction with zinceng
dc.typeTrabajo de grado - Doctoradospa
dc.type.coarhttp://purl.org/coar/resource_type/c_db06spa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/doctoralThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TDspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
dcterms.audience.professionaldevelopmentMaestrosspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

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