Desarrollo de andamios de PMMA/YSZ obtenidos por manufactura aditiva biomiméticos a cartílago nativo

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dc.contributor.advisorEstupiñan Duran, Hugo Armando
dc.contributor.authorEstrada Guerrero, Hernan Stiven
dc.contributor.orcidEstrada Guerrero, Hernan Stiven [0009000777168097]
dc.contributor.orcidEstupiñam Durán, Hugo Armando [0000000296073364]
dc.contributor.researchgroupGrupo de Investigación en Biosuperficies
dc.date.accessioned2026-01-21T21:33:04Z
dc.date.available2026-01-21T21:33:04Z
dc.date.issued2025-12-11
dc.descriptionIlustraciones
dc.description.abstractLas articulaciones son estructuras biomecánicas clave del cuerpo humano, pero también altamente vulnerables a lesiones. Entre lo que lo compone, el cartílago articular (CA) destaca por sus propiedades viscoelásticas, que permiten distribuir de manera uniforme las cargas y garantizar una fricción reducida. No obstante, múltiples factores de riesgo aumentan la susceptibilidad a lesiones. Debido a su naturaleza avascular e inervada, el CA tiene capacidad de autorreparación limitada, lo que ha impulsado numerosas investigaciones sin que aún se disponga de una solución definitiva. Ante esto, se desarrolló una biotinta tipo hidrogel compuesto por Polimetilmetacrilato (PMMA), Poli(etilenglicol)Dimetacrilato (PEGDMA) y componentes bioactivos, la cual se imprimió mediante Manufactura Aditiva (MA) sobre un sustrato biocerámico. La metodología incluyó caracterización fisicoquímica, mecánica y tribológica. El biomaterial alcanzó un hinchamiento del 16% a 30 minutos de reticulación, valor cercano al CA porcino. En degradación, el PMMA mantuvo estabilidad, mientras que el PEGDMA mostró vulnerabilidad por hidrólisis en condiciones experimentales inflamatorias. La incorporación de los componentes sulfatados bioactivos mantuvo el Coeficiente de Fricción (COF) entre 0,085 y 0,111 con cargas de 0,5 y 1 kg, a diferencia de los andamios sin sulfatos. A nivel mecánico, el AFM evidenció que bajas concentraciones de sulfatos redujeron el módulo elástico (0,39 GPa) y aumentaron la deformación, mientras que altas concentraciones lo reforzaron (6,57 GPa), con rigidez y adhesión próximas al CA porcino (440 GPa). En conjunto, se consolidó un material bioinspirado con propiedades fisicoquímicas, de fricción y mecánicas comparables al CA nativo, lo que respalda su potencial como material biomimético a CA nativo. (Texto tomado de la fuente)spa
dc.description.abstractJoints are key biomechanical structures of the human body but are also highly vulnerable to injury. Among their components, Articular Cartilage (AC) stands out for its viscoelastic properties, which enable uniform load distribution and reduced friction. However, multiple risk factors increase its susceptibility to damage. Due to its avascular and innervated nature, AC has limited self-repair capacity, which has led to many research efforts without a definitive solution. In this context, a hydrogel-type bio-ink composed of polymethyl methacrylate (PMMA), poly(ethylene glycol) dimethacrylate (PEGDMA), and bioactive components was developed and printed by Additive Manufacturing (AM) onto a bioceramic substrate. The methodology included physicochemical, mechanical, and tribological characterization. The biomaterial achieved a swelling ratio of 16% after 30 minutes of crosslinking, a value close to porcine AC. In degradation tests, PMMA maintained stability, while PEGDMA showed hydrolytic vulnerability under experimental inflammatory conditions. The incorporation of sulfated bioactive components maintained the Coefficient of Friction (COF) between 0.085 and 0.111 under loads of 0.5 and 1 kg, unlike scaffolds without sulfates. At the mechanical level, AFM analysis revealed that low sulfate concentrations reduced the elastic modulus (0.39 GPa) and increased deformation, whereas higher concentrations reinforced the network (6.57 GPa), with stiffness and adhesion values approaching those of porcine AC (440 GPa). Overall, a bioinspired material with physicochemical, friction, and mechanical properties comparable to native AC was achieved, supporting its potential as a biomimetic material to native AC.eng
dc.description.curricularareaMateriales Y Nanotecnología.Sede Medellín
dc.description.degreelevelMaestría
dc.description.degreenameMagíster en Ingeniería - Materiales y Procesos
dc.description.methodsx
dc.description.researchareaBiomateriales
dc.format.extent1 recurso en línea (123 páginas)
dc.format.mimetypeapplication/pdf
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/89290
dc.language.isospa
dc.publisherUniversidad Nacional de Colombia
dc.publisher.branchUniversidad Nacional de Colombia - Sede Medellín
dc.publisher.facultyFacultad de Minas
dc.publisher.placeMedellín, Colombia
dc.publisher.programMedellín - Minas - Maestría en Ingeniería - Materiales y Procesos
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dc.relation.referencesZhou, B., Niu, L. N., Shi, W., Zhang, W., Arola, D. D., Breschi, L., Mao, J., Chen, J. H., Pashley, D. H., & Tay, F. R. (2014). Adopting the Principles of Collagen Biomineralization for Intrafibrillar Infiltration of Yttria-Stabilized Zirconia into Three-Dimensional Collagen Scaffolds. Advanced Functional Materials, 24(13), 1895–1903. https://doi.org/10.1002/adfm.201302920
dc.relation.referencesZhu, Y., Zhang, X., Chang, G., Deng, S., & Chan, H. F. (2025). Bioactive Glass in Tissue Regeneration: Unveiling Recent Advances in Regenerative Strategies and Applications. Advanced Materials, 37(2), 2312964. https://doi.org/10.1002/adma.202312964
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc670 - Manufactura::679 -Otros productos de materiales específicos
dc.subject.lembMateriales biomédicos
dc.subject.proposalCartílagospa
dc.subject.proposalHidrogelspa
dc.subject.proposalBiomiméticospa
dc.subject.proposalCoeficiente de fricciónspa
dc.subject.proposalManufactura Aditivaspa
dc.subject.proposalCartilageeng
dc.subject.proposalHydrogeleng
dc.subject.proposalBiomimeticeng
dc.subject.proposalCoefficient of Frictioneng
dc.subject.proposalAdditive Manufacturingeng
dc.titleDesarrollo de andamios de PMMA/YSZ obtenidos por manufactura aditiva biomiméticos a cartílago nativospa
dc.title.translatedDevelopment of PMMA/YSZ scaffolds obtained by additive manufacturing biomimetic to native cartilageeng
dc.typeTrabajo de grado - Maestría
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.contentText
dc.type.driverinfo:eu-repo/semantics/masterThesis
dc.type.redcolhttp://purl.org/redcol/resource_type/TM
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2

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