Modelo matemático para el proceso de autorregulación térmica de Escherichia coli
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Benavides López, Santiago
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En el presente trabajo se desarrolla un modelo semifísico de base fenomenológica (MSBF) para el proceso de autorregulación térmica del organismo procariota Escherichia coli. La autorregulación térmica se define como el proceso fisiológico mediante el cual un organismo cambia su metabolismo ante variaciones de la temperatura ambiental. El modelo está basado en una descripción de los procesos bioquímicos globales que ocurren en el metabolismo energético y las condiciones de crecimiento aerobio en un biorreactor de tanque agitado. El ajuste del modelo se realiza con datos de la literatura para el crecimiento de E. coli K-12 cepa BW25113 a 37°C. Con el modelo se pueden predecir cambios en el metabolismo central de E. coli, el flujo de calor entre la bacteria y el entorno y la velocidad de crecimiento de la biomasa, para diferentes condiciones de temperatura del medio de cultivo
Abstract: This work presents the development of a phenomenological-based semiphysical model (PBSM) for the process of thermal self-regulation of the prokaryotic organism Escherichia coli. Thermal self-regulation is defined as the physiological process which an organism changes its metabolism to variations in environmental temperature. The model is based on a description of the global biochemical processes that occur in energy metabolism under aerobic growth conditions in an agitated tank bioreactor. The fit of the model is performed with literature data for the growth of E. coli K-12 strain BW25113 at 37°C. The model can predict changes in the central metabolism of E. coli, the heat flow between the bacteria and the environment and the growth rate of the biomass, for different temperature conditions of the culture medium..
Abstract: This work presents the development of a phenomenological-based semiphysical model (PBSM) for the process of thermal self-regulation of the prokaryotic organism Escherichia coli. Thermal self-regulation is defined as the physiological process which an organism changes its metabolism to variations in environmental temperature. The model is based on a description of the global biochemical processes that occur in energy metabolism under aerobic growth conditions in an agitated tank bioreactor. The fit of the model is performed with literature data for the growth of E. coli K-12 strain BW25113 at 37°C. The model can predict changes in the central metabolism of E. coli, the heat flow between the bacteria and the environment and the growth rate of the biomass, for different temperature conditions of the culture medium..