Modelo y simulación de dinámica de crecimiento de mieloma

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dc.contributor.advisorGarzón Alvarado, Diego Alexanderspa
dc.contributor.authorSánchez Gutiérrez, Juan Felipespa
dc.contributor.orcidJUAN FELIPE SANCHEZ GUTIERREZ, [0000-0002-7821-5234]spa
dc.contributor.researchgroupGnum Grupo de Modelado y Métodos Numericos en Ingenieríaspa
dc.date.accessioned2024-02-26T19:10:45Z
dc.date.available2024-02-26T19:10:45Z
dc.date.issued2024-02
dc.descriptionilustraciones, diagramasspa
dc.description.abstractEn este trabajo se presentan tres capítulos con modelos in-silico desarrollados a través de ecuaciones diferenciales y solucionados computacionalmente, que proporcionan una perspectiva del acoplamiento entre el ciclo de remodelación ósea y las poblaciones tumorales. Comprender las dinámicas entre el tejido sano, las células que realizan el proceso de remodelación y las diferentes patologías, como el osteosarcoma o los tumores metastásicos, es fundamental para crear estrategias m´as personalizadas y especializadas para mitigar los efectos de estas enfermedades o curarlas por completo. Los modelos presentados proveen información mas detallada de la dinámica real de la remodelación ósea en pacientes por masas tumorales. Ofrecen un marco innovador y una base solida para el desarrollo de nuevos modelos, herramientas y técnicas que permitan el desarrollo de la medicina personalizada, con una perspectiva mas completa y controlada de los procesos fisiológicos y patológicos. Se espera que en el futuro, estos modelos sean aun mas robustos y versátiles, brindando un mayor apoyo para la toma de decisiones mas acertadas en cada caso clínico particular. (Texto tomado de la fuente).spa
dc.description.abstractThis work presents three chapters with in-silico models developed through differential equations and computationally solved, providing a perspective of the coupling between the bone remodeling cycle and tumor populations. Understanding the dynamics between healthy tissue, cells involved in the remodeling process, and different pathologies, such as osteosarcoma or metastatic tumors, is fundamental for creating more personalized and specialized strategies to mitigate the effects of these diseases or cure them completely. The models presented provide more detailed information about the real dynamics of bone remodeling in patients with tumor masses. They offer an innovative framework and a solid foundation for the development of new models, tools, and techniques that enable personalized medicine, with a more comprehensive and controlled perspective of physiological and pathological processes. It is expected that in the future, these models will become even more robust and versatile, providing greater support for making more accurate decisions in each specific clinical case.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Ingeniería Mecánicaspa
dc.description.researchareaIngeniería de diseño y biomecánicaspa
dc.format.extentxvi, 103 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/85721
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Ingenieríaspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Ingeniería - Maestría en Ingeniería - Ingeniería Mecánicaspa
dc.relation.indexedBiremespa
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dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subject.ddc000 - Ciencias de la computación, información y obras generales::004 - Procesamiento de datos Ciencia de los computadoresspa
dc.subject.ddc610 - Medicina y salud::616 - Enfermedadesspa
dc.subject.decsmieloma múltiplespa
dc.subject.decsMultiple Myelomaeng
dc.subject.decsmodelos teóricosspa
dc.subject.decssimulación por ordenadorspa
dc.subject.decsComputer Simulationeng
dc.subject.proposalRemodelación óseaspa
dc.subject.proposalCrecimiento tumoralspa
dc.subject.proposalTumorspa
dc.subject.proposalModelo de Komarovaspa
dc.subject.proposalOsteoclastosspa
dc.subject.proposalOsteoblastosspa
dc.subject.proposalBone remodelingeng
dc.subject.proposalTumor Growtheng
dc.subject.proposalTumoreng
dc.subject.proposalCoupling tumor–boneeng
dc.subject.proposalKomarova’s modeleng
dc.subject.proposalOsteoclastseng
dc.subject.proposalOsteoblastseng
dc.subject.proposalCoplamiento tumor huesospa
dc.titleModelo y simulación de dinámica de crecimiento de mielomaspa
dc.title.translatedModel and Simulation of dynamics of myeloma growtheng
dc.typeTrabajo de grado - Maestríaspa
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