Identificación de genes asociados a la producción de withanólidos en Physalideae

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dc.contributor.advisorRoda Fornaguera, Federicospa
dc.contributor.authorPerez Moreno, Santiagospa
dc.contributor.researchgroupGenómica Evolutiva del Metabolismo Secundario (GEME)spa
dc.date.accessioned2024-07-16T18:26:49Z
dc.date.available2024-07-16T18:26:49Z
dc.date.issued2024
dc.descriptionilustraciones, diagramasspa
dc.description.abstractEsta tesis explora la biosíntesis y regulación de los withanolidos en la familia Solanaceae, específicamente en la tribu Physalideae, arrojando luz sobre los complejos procesos bioquímicos y genéticos que conforman su diversidad y evolución. El estudio analiza cómo se sintetizan los withanolidos, destacando la importancia de procesos bioquímicos específicos y la interacción de rutas metabólicas clave. Se enfatiza el papel crucial de ciertos procesos biológicos y genes en la modulación de la síntesis de estos compuestos, resaltando la significativa coexpresión de genes vinculados a funciones esenciales en la planta. El papel de las enzimas citocromo P450, genes específicos y clústeres biosintéticos como el propuesto WBC se examinan en profundidad, proporcionando una comprensión más profunda de la regulación genética en la producción de withanolidos. La investigación también revela interesantes interacciones entre diferentes vías metabólicas y muestra cómo la variación genética podría influir en la presencia o ausencia de ciertos withanolidos entre las especies de Solanaceae. Finalmente, la tesis ofrece una mirada a la regulación y los factores de transcripción involucrados en la producción de withanolidos, subrayando el descubrimiento de patrones de expresión genética que podrían ser fundamentales para futuras investigaciones en biotecnología vegetal y desarrollo farmacológico. Este trabajo representa un avance significativo en el conocimiento de la fitoquímica y la biología evolutiva de las plantas, destacando la complejidad y el dinamismo del mundo vegetal. (Texto tomado de la fuente).spa
dc.description.abstractThis thesis explores the biosynthesis and regulation of withanolidos in the Solanaceae family, specifically in the Physalideae tribe, shedding light on the complex biochemicaland genetic processes that shape their diversity and evolution. The study examines howwithanolidos are synthesized, highlighting the importance of specific biochemical processes and the interaction of key metabolic pathways. The crucial role of biologicalprocesses and genes, particularly cytochrome P450 enzymes, specific genes, and proposed biosynthetic clusters like WBC, is examined in depth, providing a deeper understanding of genetic regulation in withanolide production. The research also revealsintriguing interactions between different metabolic pathways and shows how genetic variation might influence the presence or absence of certain withanolidos among Solanaceae species. Finally, the thesis offers insights into the regulation and transcription factors involved in withanolide production, emphasizing the discovery of gene expression patterns that could be key for future research in plant biotechnology and pharmacological development. This work represents a significant advancement in the understanding of plant phytochemistry and evolutionary biology, highlighting the complexity and dynamism of the plant world.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Ciencias - Biologíaspa
dc.description.researchareaGenómica evolutivaspa
dc.description.sponsorshipEl proyecto "Identificación de genes asociados a la producción de withanólidos en Physalideae" recibió apoyo financiero y de recursos del Grupo de investigación de Genómica y fue patrocinado por el Tandem de Max Planck del Metabolismo Especializado (GEME). Este apoyo incluyó financiamiento y recursos necesarios para la investigaciónspa
dc.format.extent132 páginas + 1 anexospa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/86466
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Ciencias - Maestría en Ciencias - Biologíaspa
dc.relation.indexedAgrosaviaspa
dc.relation.indexedAgrovocspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/spa
dc.subject.agrovocLactonaspa
dc.subject.agrovoclactoneseng
dc.subject.agrovocPhysalisspa
dc.subject.agrovocPhysaliseng
dc.subject.agrovocgenómicaspa
dc.subject.agrovocgenomicseng
dc.subject.ddc570 - Biología::576 - Genética y evoluciónspa
dc.subject.ddc570 - Biología::572 - Bioquímicaspa
dc.subject.proposalWithanolidosspa
dc.subject.proposalBiosíntesis de withanolidosspa
dc.subject.proposalGenómica vegetalspa
dc.subject.proposalSolanaceaeother
dc.subject.proposalMetabolitos secundariosspa
dc.subject.proposalEvolución metabólicaspa
dc.subject.proposalWithanolideseng
dc.subject.proposalPlant genomicsfra
dc.subject.proposalSecondary metaboliteseng
dc.subject.proposalMetabolic evolutioneng
dc.subject.proposalWithanolide biosynthesiseng
dc.titleIdentificación de genes asociados a la producción de withanólidos en Physalideaespa
dc.title.translatedIdentification of Genes Associated with the Production of Withanolides in Physalideaeeng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.fundernameGrupo Genómica Evolutiva del Metabolismo Especializadospa

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