Extruder for 3D bioprinting with composed bioink oriented to the cellular viability evaluation in the generation of tissues

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dc.contributor.advisorCortés Rodríguez, Carlos Juliospa
dc.contributor.authorSilva Castellanos, Christian Augustospa
dc.contributor.cvlacSilva Castellanos, Christian Augusto [0001390041]spa
dc.contributor.googlescholarSilva Castellanos, Christian Augusto [9t8wUxMAAAAJ&hl]spa
dc.contributor.researchgatehttps://www.researchgate.net/profile/Christian-Silva-15spa
dc.contributor.researchgroupGrupo de Investigación en Biomecánica / Universidad Nacional de Colombia Gibm-Uncbspa
dc.date.accessioned2024-07-19T13:56:02Z
dc.date.available2024-07-19T13:56:02Z
dc.date.issued2023-02-01
dc.descriptionilustraciones, diagramas, fotografíasspa
dc.description.abstract3D bioprinting is an emerging biofabrication strategy that utilizes bioinks and models generated with CAD-like tools for the automated fabrication of tissue scaffolds and organlike constructs. Despite recent advances in materials and techniques with significant potential to achieve the fabrication of tissues relevant for clinical and in vitro applications, various aspects, such as tissue vascularization and prolonged cell functionality, are limited by the advancements in this field. Among the different 3D bioprinting techniques, extrusionbased bioprinting (EBB) has been conceived as the most promising for achieving this goal due to its versatility and availability. This document reports on developing three- and fourlayer extrusion systems axially aligned to overcome the current limitations faced when attempting to manufacture vascularized tissues and stable, perfusable vascular structures. We combined in silico simulations with in vitro experiments to precisely design multiple axial layered tissue extrusion systems with a high degree of cellular viability and versatility for 3D bioprinting applications. Furthermore, we report the hardware and software modifications made on commercially available 3D printers and bioprinters to allow the simultaneous deposition of multiple materials using coaxial nozzles. Finally, we demonstrate the versatility and potential of the four-layer coaxial extrusion system by printing perfusable vascular constructs and vascular networks with some commercially available bioinks. Our work paves the way for the rational design of coaxial extrusion systems with enormous potential in manufacturing hollow tubular constructs relevant to mimic structures found in the human body.eng
dc.description.abstractLa bioimpresión 3D es una estrategia de biofabricación emergente que emplea biotintas y modelos generados con herramientas tipo CAD para la fabricación automatizada de andamiajes de tejidos y constructos similares a órganos. A pesar de los avances recientes en materiales y técnicas con gran potencial para lograr la fabricación de tejidos relevantes para aplicaciones clínicas e in vitro, varios aspectos tales como la vascularización de tejidos y la funcionalidad prolongada de las células están limitada a los avances en este campo. Entre las diversas técnicas de bioimpresión 3D, la bioimpresión basada en extrusión (EBB) ha sido concebida como la más prometedora para lograr este objetivo, debido a su versatilidad y disponibilidad. En este documento se informa el desarrollo de sistemas de extrusión de tres y de cuatro capas alineadas axialmente destinados a resolver las limitaciones actuales que se enfrentan al intentar fabricar tejidos vascularizados y estructuras vasculares estables y perfundibles. Combinamos simulaciones in silico con experimentos in vitro para diseñar con precisión múltiples sistemas de extrusión de tejidos en capas axiales con alto grado de viabilidad celular y versatilidad para aplicaciones de bioimpresión 3D. Además, informamos las modificaciones de hardware y software realizadas en impresoras 3D y bioimpresoras disponibles comercialmente para permitir la deposición simultánea de múltiples materiales usando boquillas coaxiales. Finalmente, demostramos la versatilidad y el potencial del sistema de extrusión coaxial de cuatro capas mediante la impresión de constructos vasculares perfundibles y de redes vasculares con algunas biotintas disponibles comercialmente. Nuestro trabajo allana el camino para el diseño racional de sistemas de extrusión coaxial con gran potencial en la fabricación de constructos tubulares huecos relevantes para imitar estructuras que se encuentran en el cuerpo humano. (Texto tomado de la fuente).spa
dc.description.degreelevelDoctoradospa
dc.description.degreenameDoctor en Ingenieríaspa
dc.description.researchareaBiomechanics and tissue engineeringspa
dc.description.sponsorshipColciencias: Doctorado /Ingeniería Mecánica Universidad Nacional de Colombia Bogota, Colombia Doctorado Nacional - 647 Deutscher Akademischer Austauschdienst (DAAD), which financially supported my research internship in Germany.spa
dc.format.extentxxviii, 199 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/86572
dc.language.isoengspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Ingenieríaspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Ingeniería - Doctorado en Ingeniería - Ingeniería Mecánica y Mecatrónicaspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subject.ddc620 - Ingeniería y operaciones afines::629 - Otras ramas de la ingenieríaspa
dc.subject.ddc610 - Medicina y salud::615 - Farmacología y terapéuticaspa
dc.subject.decsSupervivencia Celularspa
dc.subject.decsCell Survivaleng
dc.subject.decsBioimpresión/instrumentaciónspa
dc.subject.decsBioprinting/instrumentationeng
dc.subject.decsIngeniería de Tejidos/métodosspa
dc.subject.decsTissue Engineering/methodseng
dc.subject.proposal3D bioprintingeng
dc.subject.proposalCoaxial printingeng
dc.subject.proposalVascularized tissueseng
dc.subject.proposalTissue-engineered vascular graftseng
dc.subject.proposalCell viabilityeng
dc.subject.proposalBioimpresión 3Dspa
dc.subject.proposalImpresión coaxialspa
dc.subject.proposalTejidos vascularizadosspa
dc.subject.proposalIngeniería tisularspa
dc.subject.proposalViabilidad celularspa
dc.titleExtruder for 3D bioprinting with composed bioink oriented to the cellular viability evaluation in the generation of tissueseng
dc.title.translatedExtrusor para bioimpresión 3D con biotinta compuesta orientado a la evaluación de viabilidad celular en la generación de tejidosspa
dc.typeTrabajo de grado - Doctoradospa
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dc.type.redcolhttp://purl.org/redcol/resource_type/TDspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.fundernameColcienciasspa
oaire.fundernameDAADspa

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