Creación de un protocolo para la construcción de curvas de supervivencia sobre la línea celular SiHa utilizando un acelerador lineal de uso clínico

dc.contributor.advisorRodríguez, Josefa Antoniaspa
dc.contributor.advisorPlazas, María Cristinaspa
dc.contributor.authorChona Perea, Rafael Estebanspa
dc.contributor.colaboratorRumbo, Génesisspa
dc.contributor.colaboratorMejía, Vanessaspa
dc.contributor.colaboratorPabón, Alexandraspa
dc.date.accessioned2023-06-07T19:19:02Z
dc.date.available2023-06-07T19:19:02Z
dc.date.issued2023-06-04
dc.descriptionilustraciones, fotografías, gráficasspa
dc.description.abstractA finales del siglo XIX, poco después de la invención de los rayos X, se descubrió que la radiación ionizante podía ser utilizada como tratamiento oncológico. Durante el siguiente siglo se realizaron una serie de experimentos in vivo e in vitro, que buscaban explicar las propiedades de la interacción radiación-célula, creando el campo de la radiobiología. A partir de estas investigaciones se desarrolló el modelo lineal-cuadrático, que sirve para cuantificar el daño letal y sub-letal de la radiación en la célula, comparando la dosis recibida con la fracción de supervivencia celular. Esto se conoce como una curva de supervivencia celular y es muy útil para comparar distintas características de un tratamiento en radioterapia (como fraccionamiento, calidad de la radiación, entre otras). En este trabajo final de maestría se busca crear un protocolo de construcción de curvas de supervivencia celular utilizando haces de radiación de 6 MeV con un acelerador lineal para facilitar la realización de experimentos radiobiólogicos en el futuro. (Texto tomado de la fuente).spa
dc.description.abstractAt the end of the XIX century, right after the invention of xrays, it was discovered that ionizing radiation could be used as oncological treatment. During the following century a lot of advancements were made trying to understand that connection, in particular a lot of in vivo and in vitro experiments were made improving our understanding of the interaction of radiation and the cell, creating the field of Radiobiology. Using that research as a starting point the Lineal quadratic model was created, to attempt to quantify the lethal and sublethal damage produce to the cell by quantifying the cellular death with the dose prescribed. This is what is know as Cell Survival curve and it is very useful to define the reaction of tissue and cells after being expose to radiation. This study aims to develop a guide to create cell survival curves using what is known as an MTT assay for determining the impact of the radiation in the cell.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Física Médicaspa
dc.format.extent70 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/83994
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Ciencias - Maestría en Física Médicaspa
dc.relation.indexedBiremespa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseReconocimiento 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/spa
dc.subject.ddc610 - Medicina y salud::615 - Farmacología y terapéuticaspa
dc.subject.decsRadioterapia/métodosspa
dc.subject.decsRadiotherapy/methodseng
dc.subject.decsRadiación Ionizantespa
dc.subject.decsRadiation, Ionizingeng
dc.subject.decsSupervivencia Celular/efectos de la radiaciónspa
dc.subject.decsCell Survival/radiation effectseng
dc.subject.proposalRadiobiologíaspa
dc.subject.proposalRadioterapiaspa
dc.subject.proposalCultivo Celulaspa
dc.subject.proposalEnsayo de supervivencia celularspa
dc.subject.proposalRadiobiologyeng
dc.subject.proposalRadioterapyeng
dc.subject.proposalCell suvirval Essayeng
dc.subject.proposalCell Cultureeng
dc.subject.proposalIonazing radiationeng
dc.subject.proposalRadiación ionizantespa
dc.titleCreación de un protocolo para la construcción de curvas de supervivencia sobre la línea celular SiHa utilizando un acelerador lineal de uso clínicospa
dc.title.translatedCreation of a cell survival curve protocol for irradiated SiHa cells using a clinical linear acceleratoreng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentEstudiantesspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
dcterms.audience.professionaldevelopmentPúblico generalspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

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