Evaluación de compuestos nutracéuticos en cerdos posdestete sobre la dinámica de desarrollo microbiano como biomarcador asociado a la expresión de mRNA de proteínas de salud intestinal

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dc.contributor.advisorParra Suescún, Jaime
dc.contributor.advisorLópez Herrera, Albeiro
dc.contributor.authorÁngel Isaza, Jaime Andres
dc.contributor.googlescholarhttps://scholar.google.es/citations?user=oN_sET4AAAAJ&hl=esspa
dc.contributor.orcidÁngel Isaza, Jaime Andres [0000-0003-1612-6938]spa
dc.contributor.researchgroupBiodiversidad y Génetica Molecular "Biogem"spa
dc.date.accessioned2025-03-25T14:04:30Z
dc.date.available2025-03-25T14:04:30Z
dc.date.issued2025
dc.descriptionIlustraciones, gráficasspa
dc.description.abstractEn el ciclo de producción del cerdo, la fase posdestete es de gran importancia, debido a que confluyen factores estresantes que generan desbalance de la microbiota intestinal, alterando la salud de los lechones y causando diarreas. Los productores han recurrido al uso de antibióticos en el alimento, sin embargo, esta práctica ya se ha prohibido en diversos países por la posible inducción de resistencia microbiana. El objetivo del presente estudio fue evaluar la suplementación de aditivos alimenticios sobre la composición microbiana como biomarcador asociado a la expresión de proteínas de salud intestinal en cerdos durante el posdestete. Se utilizaron 240 lechones, distribuidos en seis dietas: (D1) alimento base, (D2) D1 + 350 ppm de bacitracina de zinc, (D3) D1 + 550 ppm de maltodextrina, (D4) D1 + 300 ppm de fructooligosacáridos, (D5) D1 + 69 ppm de aceite esencial de Lippia origanoides, y (D6) D1 + 750 ppm de humatos de sodio. Se evaluaron parámetros clínicos y productivos, así como muestras intestinales para el análisis del desarrollo morfológico, la expresión de proteínas de barrera y enzimáticas, y la composición microbiana ileal y fecal. Se observó que los fructooligosacáridos y aceite esencial de Lippia origanoides mejoraron la productividad, el desarrollo morfométrico, la expresión molecular de proteínas enzimáticas y de barrera, además de modular positivamente las comunidades microbianas ileales y fecales de los lechones en comparación con el D1 y D2. En conclusión, estos dos compuestos se postulan como alternativas biotecnológicas al uso de promotores de crecimiento antibióticos durante el posdestete. (Tomado de la fuente)spa
dc.description.abstractIn the pig production cycle, the post-weaning phase is of great importance, as stress factors converge, causing an imbalance in the intestinal microbiota, which affects the health of piglets and leads to diarrhea. Producers have traditionally relied on antibiotics in feed; however, this practice has been banned in several countries due to the potential induction of antimicrobial resistance. The aim of this study was to evaluate the supplementation of feed additives on microbial composition as a biomarker associated with the expression of intestinal health proteins in post-weaning pigs. A total of 240 piglets were used, divided into six diets: (D1) basal diet, (D2) D1 + 350 ppm zinc bacitracin, (D3) D1 + 550 ppm maltodextrin, (D4) D1 + 300 ppm fructooligosaccharides, (D5) D1 + 69 ppm Lippia origanoides essential oil, and (D6) D1 + 750 ppm sodium humates. Clinical and productive parameters were evaluated, along with intestinal samples for analysis of morphometric development, the expression of barrier and enzymatic proteins, and ileal and fecal microbial composition. It was observed that fructooligosaccharides and Lippia origanoides essential oil improved productivity, morphometric development, and the molecular expression of enzymatic and barrier proteins. Additionally, these additives positively modulated ileal and fecal microbial communities in comparison with D1 and D2. In conclusion, these two compounds are proposed as biotechnological alternatives to antibiotic growth promoters during the post-weaning phase.eng
dc.description.curricularareaBiotecnología.Sede Medellínspa
dc.description.degreelevelDoctoradospa
dc.description.degreenameDoctorado en Biotecnologíaspa
dc.format.extent160 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/87723
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Medellínspa
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.placeMedellín, Colombiaspa
dc.publisher.programMedellín - Ciencias - Doctorado en Biotecnologíaspa
dc.relation.indexedLaReferenciaspa
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dc.rights.licenseAtribución-NoComercial 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/spa
dc.subject.ddc630 - Agricultura y tecnologías relacionadas::636 - Producción animalspa
dc.subject.ddc570 - Biología::573 - Sistemas fisiológicos específicos en animales, histología regional y fisiología en los animalesspa
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dc.subject.ddc590 - Animales::599 - Mamíferosspa
dc.subject.lembIndustria de la carne de cerdo
dc.subject.lembCarne de cerdo - Calidad
dc.subject.lembAlimentos para animales - Producción
dc.subject.lembBiotecnología de alimentos
dc.subject.proposalPorciculturaspa
dc.subject.proposalMicrobiotaspa
dc.subject.proposalCerdospa
dc.subject.proposalPrebióticospa
dc.subject.proposalFitobióticospa
dc.subject.proposalSwine productioneng
dc.subject.proposalMicrobiotaeng
dc.subject.proposalPrebioticeng
dc.subject.proposalPigeng
dc.subject.proposalPhytobioticeng
dc.titleEvaluación de compuestos nutracéuticos en cerdos posdestete sobre la dinámica de desarrollo microbiano como biomarcador asociado a la expresión de mRNA de proteínas de salud intestinalspa
dc.title.translatedEvaluation of feed additives in post-weaning pigs on microbial composition as a biomarker associated with mRNA expression of intestinal health proteinseng
dc.typeTrabajo de grado - Doctoradospa
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