Dosimetría en haces de radiación usados en la Radioterapia FLASH con haces de electrones de 7 MeV

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dc.contributor.advisorHeinrich, Sophie
dc.contributor.advisorPlazas de Pinzón, María Cristina
dc.contributor.authorAvilés León, Valentina
dc.contributor.cvlacAviles, Valentina [https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000128868]spa
dc.contributor.cvlacAviles, Valentina [0000128868]spa
dc.contributor.researchgroupGrupo Fisica Medica Unalbspa
dc.date.accessioned2024-07-16T19:51:58Z
dc.date.available2024-07-16T19:51:58Z
dc.date.issued2024-07-11
dc.descriptionilustraciones, diagramas, fotografías, tablasspa
dc.description.abstractEl fenómeno radiobiológico conocido como efecto FLASH ha despertado considerable interés en la comunidad científica mundial. Estudios preclínicos han resaltado su notable capacidad para mitigar los efectos colaterales en tejidos sanos mientras mantiene la eficacia en tejidos tumorales. Este procedimiento juega un papel crucial en la expansión de las posibilidades terapéuticas y en mejorar la efectividad de la radioterapia al administrar dosis altas de radiación en intervalos de tiempo extremadamente corto, con tasas de dosis promedio excepcionalmente altas que superan los 40 Gy/s. Es importante destacar que la irradiación instantánea con dosis de energía ultra alta asociada con la Radioterapia FLASH presenta desafíos significativos en la medición y cuantificación de la dosis. La escasez de literatura, protocolos y orientación en este campo es uno de los desafíos que enfrenta esta área de investigación. A pesar de numerosos estudios sobre dosimetría en radioterapia FLASH, sigue existiendo una brecha considerable en el conocimiento de física médica. Además, considerar la relación entre parámetros temporales del haz de radiación, como la tasa de dosis, dosis por pulso y tasa de dosis promedio dentro del pulso, sigue siendo un desafío significativo. En este trabajo final de maestría, se llevarán a cabo mediciones dosimétricas de haces de electrones de 5 y 7 MeV, tanto en modalidades convencionales como FLASH. Este enfoque jugará un papel crucial en la comprensión de la dosimetría en la Radioterapia FLASH. Se anticipa que procedimientos como la determinación de curvas de PDD, controles de calidad diarios tanto para modalidades FLASH como convencionales, la evaluación de la dosis por pulso [Gy/pulso] en relación con la longitud real del pulso [µs], y la determinación de los output factors, entre otras medidas dosimétricos incorporados en este estudio, contribuirán significativamente a la caracterización precisa del haz de electrones para ambas energías. Este enriquecimiento se traducirá en una comprensión más profunda de la dosimetría para haces de electrones de ultra alta energía, fortaleciendo la base de conocimientos esencial para su aplicación en protocolos de aseguramiento de calidad de haces de radiación. (Texto tomado de la fuente)spa
dc.description.abstractThe radiobiological phenomenon known as the FLASH effect has sparked considerable interest in the global scientific community. Preclinical studies have highlighted its remarkable ability to mitigate adverse effects on healthy tissues while maintaining efficacy in tumor tissues. This procedure plays a crucial role in expanding therapeutic possibilities and improving the effectiveness of radiotherapy by delivering high-energy doses in brief time intervals, with exceptionally high average dose rates exceeding 40 Gy/s. It is noteworthy that instantaneous irradiation with ultra-high energy doses associated with FLASH Radiotherapy poses significant challenges in measuring and quantifying the dose. The scarcity of literature, protocols, and guidance in this field is one of the challenges facing this research area. Despite numerous studies on dosimetry in FLASH radiotherapy, there remains a considerable gap in medical physics knowledge. Additionally, considering the relationship betweentemporal parameters of the radiation beam, such as dose rate, dose per pulse, and average dose rate within the pulse, remains a significant challenge. In this final master’s thesis proposal, dosimetric measurements of 5 and 7 MeV electron beams will be conducted, both in conventional and FLASH modes. This approach will play a crucial role in understanding dosimetry in FLASH Radiotherapy. It is anticipated that procedures such as determining PDD curves, daily quality controls for both FLASH and conventional modalities, evaluating the dose per pulse [Gy/pulse] in relation to the actual pulse length [µs], and determining output factors, among other dosimetric tests incorporated in this study, will significantly contribute to the precise characterization of the electron beam for both energies. This enrichment will translate into a deeper understanding of dosimetry for ultra-high-energy electron beams, strengthening the essential knowledge base for their application in radiation beam quality assurance protocols.eng
dc.description.degreelevelMaestríaspa
dc.description.degreenameMagíster en Física Médicaspa
dc.description.researchareaRadioterapia FLASHspa
dc.format.extentxv, 79 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/86477
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Ciencias - Maestría en Física Médicaspa
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dc.rightsDerechos reservados al autor, 2024spa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/spa
dc.subject.ddc530 - Física::539 - Física modernaspa
dc.subject.decsRadiometríaspa
dc.subject.decsRadiometryeng
dc.subject.proposalRadioterapia FLASHspa
dc.subject.proposalFLASH Radiotherapyeng
dc.subject.proposalradioterapia convencionalspa
dc.subject.proposalconventional radiotherapyeng
dc.subject.proposalacelerador lineal de electronesspa
dc.subject.proposalelectron linear acceleratoreng
dc.subject.proposaldosimetríaspa
dc.subject.proposaldosimetryeng
dc.subject.proposalQAspa
dc.subject.proposalQAeng
dc.subject.proposalPDDspa
dc.subject.proposalPDDspa
dc.subject.proposaloutput factorsspa
dc.subject.proposaloutput factorseng
dc.subject.unescoEfectos de las radiacionesspa
dc.subject.unescoRadiation effectseng
dc.titleDosimetría en haces de radiación usados en la Radioterapia FLASH con haces de electrones de 7 MeVspa
dc.title.translatedDosimetry in Radiation Beams Used in FLASH Radiotherapy with 7 MeV Electron Beamseng
dc.typeTrabajo de grado - Maestríaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentEstudiantesspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
dcterms.audience.professionaldevelopmentPadres y familiasspa
dcterms.audience.professionaldevelopmentPúblico generalspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

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