Estudio de la composición del hongo Lentinula edodes usando herramientas ómicas y su potencial en la producción de un alimento funcional

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dc.contributor.advisorArdila Barrantes, Harold Duban
dc.contributor.advisorChegwin Angarita, Carolina
dc.contributor.authorVega Oliveros, Carolina
dc.contributor.researchgroupEstudio de Actividades Metabolicas Vegetalesspa
dc.contributor.researchgroupQuímica de Hongos Macromicetos Colombianosspa
dc.date.accessioned2022-08-18T20:07:45Z
dc.date.available2022-08-18T20:07:45Z
dc.date.issued2021
dc.description.abstractLentinula edodes es una especie fúngica perteneciente a los macromicetos para la cual se han reportado metabolitos y proteínas que presentan diversas actividades biológicas con potencial en la industria de alimentos. En la presente tesis doctoral se aporta al conocimiento bioquímico de este potencial, mediante la exploración química y el estudio de bioactividad presente en el micelio de esta especie obtenido mediante fermentación en estado líquido (FEL); estrategia de cultivo biotecnológico que permite la obtención eficiente de material biológico con fines industriales. Para ello inicialmente se determinaron algunos parámetros experimentales para su cultivo en condiciones de laboratorio y se seleccionaron dos medios que presentaron los mejores resultados en la producción de metabolitos y proteínas totales. Posteriormente usando ensayos de actividad biológica in vitro y estrategias propias de la proteómica y la metabolómica, se estudió la composición del micelio producido en dichos medios y se profundizó sobre sus potenciales características nutracéuticas. De acuerdo con los resultados encontrados en la presente investigación, el micelio producido mediante FEL en medios como GPY (Glucosa, Peptona y Levadura) y Bienestarina, presenta metabolitos y proteínas con potenciales usos en la industria de alimentos. Específicamente, el micelio obtenido en medio GPY mostró importante actividad antioxidante evaluada sobre EROs (especies reactivas de oxígeno) y ERN (especies reactivas de nitrógeno); muy posiblemente asociada a la presencia de diferentes compuestos hidroxilados, incluyendo un derivado de tipo flavanona. Así mismo, el micelio generado a partir del medio bienestarina contiene diversas proteínas con usos potenciales en la industria de alimentos, incluyendo algunas lectinas con reportada acción inmunomoduladora. El estudio preliminar de la incorporación del micelio obtenido en un alimento de tipo postre, permitió profundizar sobre el potencial del hongo propagado en GPY para ser usado en la generación de alimentos con potencial nutraceutico. La presente investigación profundiza sobre la bioquímica de la producción de metabolitos y proteínas en esta especie y se constituye como el primer estudio conjunto a nivel proteómico y metabolómico del potencial nutracéutico en macromicetos. (Texto tomado de la fuente)spa
dc.description.abstractLentinula edodes is a fungal species belonging to the macromycetes for which various biological activities with potential in the food industry have been reported due to its proteins and metabolites. This doctoral thesis contributes to the biochemical knowledge of this potential through chemical exploration and the study of bioactivity present in the mycelium of this species obtained by liquid-state fermentation (FEL); biotechnological cultivation strategy that allows the efficient obtaining of biological material for industrial purposes. For this, some experimental parameters were initially determined for their culture in laboratory conditions, and two liquid media were selected because they induced the mushroom to the best results in the production of metabolites and total proteins. Subsequently, the composition of the mycelium produced was studied using in vitro biological activity tests and strategies of proteomics and metabolomics, and the nutraceutical characteristics potential of their mycelia were studied. According to the results found in the present investigation, the mycelium produced by FEL in GPY media (Glucose, Peptone, and Yeast) and BIE (Bienestarina) presented metabolites and proteins with potential uses in the food industry. Specifically, the mycelium obtained in GPY medium presented important antioxidant activity evaluated on ROS (reactive oxygen species) and RNS (reactive nitrogen species); this antioxidant activity could be associated with the presence of different hydroxylated compounds, including a derivative of the flavanone type. Likewise, the mycelium generated from the BIE medium presented a wide variety of proteins with potential uses in the food industry, including some lectins with reported immunomodulatory action. The preliminary study of incorporating the mycelium obtained in a dessert-type food allowed to deepen the potential of the fungus propagated in GPY to be used in the generation of food formulations with nutraceutical potential. This research delves into the biochemistry of the production of metabolites and proteins in this species and constitutes the first joint study at the proteomic and metabolomic level of the nutraceutical potential in macromycetes.eng
dc.description.degreelevelDoctoradospa
dc.description.degreenameDoctorado en Ciencias - Bioquímicaspa
dc.format.extentxxv, 325 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/81964
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.departmentDepartamento de Químicaspa
dc.publisher.facultyFacultad de Cienciasspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Ciencias - Doctorado en Ciencias - Bioquímicaspa
dc.relation.indexedRedColspa
dc.relation.indexedLaReferenciaspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subject.agrovocLentinula edodes
dc.subject.ddc570 - Biología::579 - Historia natural microorganismos, hongos, algasspa
dc.subject.proposalFermentación sumergidaspa
dc.subject.proposalBioactivospa
dc.subject.proposalMetabolitosspa
dc.subject.proposalMacromicetospa
dc.subject.proposalFuncionalspa
dc.subject.proposalNutracéuticospa
dc.subject.proposalSubmerged fermentationeng
dc.subject.proposalBioactiveeng
dc.subject.proposalMetaboliteseng
dc.subject.proposalMacromyceteeng
dc.subject.proposalFunctionaleng
dc.subject.proposalNutraceuticaleng
dc.titleEstudio de la composición del hongo Lentinula edodes usando herramientas ómicas y su potencial en la producción de un alimento funcionalspa
dc.title.translatedStudy of the composition of the mushroom Lentinula edodes using omics tools and its potential in the production of a functional foodeng
dc.typeTrabajo de grado - Doctoradospa
dc.type.coarhttp://purl.org/coar/resource_type/c_db06spa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/doctoralThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TDspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentEstudiantesspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
dcterms.audience.professionaldevelopmentMaestrosspa
dcterms.audience.professionaldevelopmentPúblico generalspa
dcterms.audience.professionaldevelopmentReceptores de fondos federales y solicitantesspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa
oaire.awardtitleCrédito condonable Convocatoria 785 de colciencias para doctorados nacionales 2017spa
oaire.awardtitleDiseño bioguiado apoyado con herramientas ómicas de un alimento funcional obtenido mediante la adición del hongo Lentinula edodes (Código 47146)spa
oaire.awardtitlePotencial del hongo Lentinula edodes como productor de nutraceúticos en biorreactores (código 41634)spa
oaire.awardtitleBioprospección de hongos macromicetos en busca de fuentes de materias primas para la industria alimenticia y agrícola (código 41455)spa
oaire.fundernameMinCienciasspa
oaire.fundernameUniversidad Nacional de Colombia sede Bogotáspa

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