Caracterización del potencial oncolítico del aislamiento rotaviral Wt1-5 en cultivos primarios de leucemia linfoblástica aguda de precursores B
| dc.contributor.advisor | Guerrero Fonseca, Carlos Arturo | spa |
| dc.contributor.advisor | Acosta Losada, Orlando | spa |
| dc.contributor.author | Guerrero Rojas, Rafael Antonio | spa |
| dc.contributor.corporatename | Laboratorio de Biología Molecular de Virus - Facultad de Medicina - Universidad Nacional de Colombia | spa |
| dc.contributor.researchgroup | Biología Molecular de virus | spa |
| dc.date.accessioned | 2020-09-04T17:00:01Z | spa |
| dc.date.available | 2020-09-04T17:00:01Z | spa |
| dc.date.issued | 2018-09-28 | spa |
| dc.description.abstract | Cancer is a major health problem that poses a great challenge to health care systems around the world. Current tools for cancer treatment have advanced rapidly in recent years, resulting in new alternative and complementary therapeutic strategies to conventional treatment. Work aims to identify the oncolytic potential of rotavirus Wt1-5 adapted to tumor cells, in addition, to establish the cell surface receptors and markers of cell death induced by rotavirus infection in B- cell acute lymphoblastic leukemia cells and Reh cells. We used Wt1 -5 rotavirus isolate recently adapted to tumor cells, to infect the B- cell acute lymphoblastic leukemia cells and Reh cells. We assessed rotavirus infection by viral antigens detection through flow cytometry analysis. Also, we analyze some cell surface proteins and cell death markers induced by viral infection. The assays showed that rotavirus Wt1 -5 was able to use cell-surface proteins such as heat shock proteins Hsp90, Hsp70, Hsc70, PDI, and β3 integrin. Rotavirus Wt1-5 induced cytotoxic effects including changes in cell membrane permeability, alteration of mitochondrial membrane potential, DNA fragmentation, and activation of cell death signaling. We conclude that rotavirus Wt1 -5 may be a potential candidate to be used as an oncolytic agent. This rotavirus could induce apoptosis as a cell death mechanism in B- cell acute lymphoblastic leukemia cells and Reh cells. | spa |
| dc.description.abstract | El cáncer es un importante problema de salud que plantea un gran desafío para los sistemas de atención de salud en todo el mundo. Las herramientas para el tratamiento del cáncer han avanzado rápidamente en los últimos años, dando como resultado nuevas estrategias terapéuticas alternativas y complementarias al tratamiento convencional. Este trabajo busca identificar el potencial oncolítico del rotavirus Wt1-5 adaptado a células tumorales y algunos de los receptores de superficie celular utilizados por el rotavirus Wt1-5 y los marcadores de muerte celular inducidos por la infección en células de leucemia linfoblástica aguda de precursores B y células Reh. Para esto, se usó el aislamiento de rotavirus Wt -5 recientemente adaptado a células tumorales, para infectar las células de leucemia linfoblástica aguda de precursores B y las células Reh. La infección por rotavirus Wt1 -5 fue seguida mediante análisis de antígenos virales por citometría de flujo. Se evaluaron algunas proteínas de superficie celular como posibles receptores y marcadores de muerte celular inducidos por la infección viral. El trabajo muestra que el rotavirus Wt1-5 fue capaz de utilizar las proteínas de la superficie celular como las proteínas de choque térmico Hsp90, Hsp70, Hsc70, PDI e integrina β3. El rotavirus Wt1-5 indujo efectos citotóxicos que incluyen cambios en la permeabilidad de la membrana celular, alteración del potencial de membrana mitocondrial, fragmentación del ADN y activación de la señalización de la muerte celular. Concluimos que el rotavirus Wt1 -5 puede ser un candidato potencial para ser utilizado como un agente oncolítico y que la apoptosis podría ser un mecanismo por el cual Wt1-5 reducir la viabilidad de las células de leucemia linfoblástica aguda de precursores y las células Reh. | spa |
| dc.description.additional | Línea de Investigación: Virus Oncolíticos | spa |
| dc.description.degreelevel | Doctorado | spa |
| dc.description.project | Evaluación in vitro de virus oncolítico para el tratamiento de leucemia linfoblástica aguda en muestras de sangre periférica de pacientes en edad pediátrica. | spa |
| dc.description.sponsorship | Departamento Administrativo de Ciencia, Tecnología e Innovación, COLCIENCIAS, Convocatoria No. 110171250829. | spa |
| dc.format.extent | 216 | spa |
| dc.format.mimetype | application/pdf | spa |
| dc.identifier.citation | Rafael A. Guerrero, Carlos A. Guerrero, Orlando Acosta. (2018) Caracterización del potencial oncolítico del aislamiento rotaviral Wt1 -5 en cultivos primarios de leucemia linfoblástica aguda de precursores B. Doctorado en Biotecnología, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá-Colombia | spa |
| dc.identifier.uri | https://repositorio.unal.edu.co/handle/unal/78384 | |
| dc.language.iso | spa | spa |
| dc.publisher.branch | Universidad Nacional de Colombia - Sede Bogotá | spa |
| dc.publisher.program | Bogotá - Ciencias - Doctorado en Biotecnología | spa |
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| dc.rights | Derechos reservados - Universidad Nacional de Colombia | spa |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess | spa |
| dc.rights.license | Atribución-NoComercial-SinDerivadas 4.0 Internacional | spa |
| dc.rights.spa | Acceso abierto | spa |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | spa |
| dc.subject.ddc | 610 - Medicina y salud | spa |
| dc.subject.proposal | Rotavirus | spa |
| dc.subject.proposal | Rotavirus | eng |
| dc.subject.proposal | Oncolytic viruses | eng |
| dc.subject.proposal | Virus oncolíticos | spa |
| dc.subject.proposal | Leucemia linfoblástica aguda | spa |
| dc.subject.proposal | Acute lymphoblastic leukemia | eng |
| dc.subject.proposal | heat shock proteins | eng |
| dc.subject.proposal | PDI | spa |
| dc.subject.proposal | Integrina β3 | spa |
| dc.subject.proposal | PDI | eng |
| dc.subject.proposal | Integrin-β3 | eng |
| dc.subject.proposal | Proteínas de choque térmico | spa |
| dc.title | Caracterización del potencial oncolítico del aislamiento rotaviral Wt1-5 en cultivos primarios de leucemia linfoblástica aguda de precursores B | spa |
| dc.title.alternative | Characterization of the oncolytic potential of rotaviral isolate Wt1 -5 in primary cultures of precursor B-cell lymphoblastic leukemia | spa |
| dc.type | Trabajo de grado - Doctorado | spa |
| dc.type.coar | http://purl.org/coar/resource_type/c_db06 | spa |
| dc.type.coarversion | http://purl.org/coar/version/c_ab4af688f83e57aa | spa |
| dc.type.content | Text | spa |
| dc.type.driver | info:eu-repo/semantics/doctoralThesis | spa |
| dc.type.version | info:eu-repo/semantics/acceptedVersion | spa |
| oaire.accessrights | http://purl.org/coar/access_right/c_abf2 | spa |