Análisis de la recuperación de terpenos y cannabinoides provenientes del cannabis utilizando destilación de película agitada al vacío
Cargando...
Archivos
Autores
Sánchez Castañeda, Santiago
Director
Tipo de contenido
Document language:
Español
Fecha
Título de la revista
ISSN de la revista
Título del volumen
Documentos PDF
Resumen
Abstract
The cannabis industry in Colombia and the world faces crucial challenges in process stan-
dardization, aiming to deliver high-quality and reproducible products during cultivation and
establishment. In this context, the intersection of quality and productivity plays a crucial
role in the industry. This has led to a series of optimizations in the stages of the medicinal
cannabis value chain. In this case, simultaneous modifications were made to the internal
condensation temperature (TIC) and evaporation (TEV), feed pump frequency (FBA), and
system pressure (PIN) to recognize the variation in the selected responses in the short-path
distillation equipment belonging to Medcolcanna (MCCN).
The objective was to establish optimal conditions to increase process yield without compro-
mising the quality of the final distillate. To achieve this, the response surface methodology
was implemented, allowing for modeling and prediction of the responses such as predominant
cannabinoid potency (POT), mass yield of the distillate (RMA), separation efficiency (EFI),
and total cannabinoids content in the distillate (CTO) by simultaneously modifying the pro-
cess parameters. The implementation of this methodology proved to be effective, finding that
for CBD-dominant distillation, the conditions of 172°C for TEV, 125°C for TIC, 5 Pa for
PIN, and 10 for FBA resulted in a potency (POT) of 78.47 ± 2.63 %, mass yield (RMA) of
64.07 ± 2.19 %, and an efficiency (EFI) of 92.67 ± 3.86 %. Additionally, distillates with THC
predominance highlighted the importance of cannabis variety, as other cannabinoids present
in the distillate stood out compared to CBD distillate. Therefore, the cannabinoid separation
stage was in line with expectations, obtaining total cannabinoids (CTO) of 86.39 ± 2.36 %,
RMA of 62.34 ± 2.22 %, EFI of 83.35 ± 4.24 %, and POT of 53.49 ± 1.49 %. With these
achievements, Medcolcanna, a leading company in the industry, was able to obtain distillates
with interesting specifications for the market and subsequent processes. Furthermore, they
achieved an increase in CBD-dominant distillate production from 1.0 to 5.5 kg/h and started
distilling at a flow rate of 1.8 kg/h for high-THC varieties. These advancements enable the
company to efficiently and safely deliver high-quality products, meeting the demands of a
constantly developing market.
Lastly, in the search for terpenes, which play a crucial role in the organoleptic and thera-
peutic properties of the final products, it was evident that the sample preparation process
for distillation directly influences the quantity of these compounds for the operation. Ap-
proximately 76.41 % of them are lost between the flower and the full-spectrum extract, and
only 5.34 % is recovered in the distillate. Therefore, it is suggested to recover these types of compounds in pre-distillation operations or even modify the value chain to avoid thermal
processes that decrease the recovery.
Palabras clave propuestas
Descripción
ilustraciones, diagramas