Riesgo de cáncer gástrico en pacientes con gastritis atrófica y metaplasia intestinal en estadios OLGA y OLGIM III y IV: revisión sistemática y metanálisis

dc.contributor.advisorOtero Regino, William Albertospa
dc.contributor.authorFrias Ordoñez, Juan Sebastianspa
dc.contributor.cvlachttps://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0001772314spa
dc.contributor.googlescholarhttps://scholar.google.com/citations?user=fV--MAwAAAAJ&hl=es&oi=aospa
dc.contributor.orcidFrias Ordoñez, Juan Sebastian [0000000327352922]spa
dc.contributor.researchgatehttps://www.researchgate.net/profile/Juan-Frias-Ordonezspa
dc.contributor.scopusFrias Ordoñez, Juan Sebastian [57193738162]spa
dc.date.accessioned2024-12-11T13:41:54Z
dc.date.available2024-12-11T13:41:54Z
dc.date.issued2024
dc.descriptionilustraciones, diagramasspa
dc.description.abstractIntroducción y objetivo: Estudios recientes han encontrado que pacientes con OLGA II, también pueden tener riesgo de cáncer gástrico (CG) a largo plazo y más aún si tienen familiares de primer grado con CG. El objetivo del presente metaanálisis es determinar si los estadios de OLGA II-IV tienen riesgo de CG y cuál es su magnitud, así como también estimar si el riesgo aumenta cuando hay familiares de primer grado con CG. Metodología: Revisión sistemática y metaanálisis. Se buscarán en varias bases de datos, incluyendo PubMed, EMBASE, Medline y la biblioteca Cochrane, artículos publicados en los últimos 10 años hasta mayo de 2024 sobre la asociación entre los diferentes estadios OLGA/OLGIM y el riesgo de GC. Análisis estadístico con estimación del efecto en términos de Odds Ratio (OR), riesgo relativo (RR) e intervalo de confianza del 95%. La heterogeneidad se estimará con I2 y Chi2. Resultados: De 273 artículos recuperados mediante nuestra búsqueda bibliográfica, se incluyeron un total 28 estudios que comprendían 23390 pacientes, se incluyeron 15 estudios de casos y controles, corte transversal, y 13 estudios de cohortes. El metaanálisis demostró una asociación significativa entre los estadios II-IV de OLGA/OLGIM y cáncer gástrico. El análisis de subgrupos en poblaciones con baja prevalencia de infección por H. pylori no encontró asociación del puntaje OLGIM en los estudios de cohorte. Conclusiones: Se presenta una versión resumida de las asociaciones estimadas de los diferentes estadios de OLGA/OLGIM y riesgo de CG (Texto tomado de la fuente).spa
dc.description.abstractIntroduction and objective: Recent studies have found that patients with OLGA II may also be at risk of gastric cancer (GC) in the long term and even more so if they have first-degree relatives with GC. The aim of the present meta-analysis is to determine whether OLGA stages II-IV are at risk of GC and what is its magnitude, as well as to estimate whether the risk increases when there are first-degree relatives with GC. Methodology: Systematic review and meta-analysis. Several databases, including PubMed, EMBASE, Medline and Cochrane library, will be searched for articles published in the last 10 years until May 2024 on the association between different OLGA/OLGIM stages and GC risk. Statistical analysis with estimation of effect in terms of Odds Ratio (OR), relative risk (RR) and 95% confidence interval. Heterogeneity will be estimated with I2 and Chi2. Results: Of 273 articles retrieved through our literature search, a total of 28 studies comprising 23390 patients were included, 15 case-control, cross-sectional, and 13 cohort studies. The meta-analysis demonstrated a significant association between OLGA/OLGIM stages II-IV and gastric cancer. Subgroup analysis in populations with low prevalence of H. pylori infection found no association of OLGIM score in cohort studies. Conclusions: A summarized version of the estimated associations of different OLGA/OLGIM stages and GC risk is presented.eng
dc.description.degreelevelEspecialidades Médicasspa
dc.description.degreenameEspecialista en Gastroenterologíaspa
dc.description.methodsRevisión sistemática y metaanálisis. Se buscarán en varias bases de datos, incluyendo PubMed, EMBASE, Medline y la biblioteca Cochrane, artículos publicados en los últimos 10 años hasta mayo de 2024 sobre la asociación entre los diferentes estadios OLGA/OLGIM y el riesgo de GC. Análisis estadístico con estimación del efecto en términos de Odds Ratio (OR), riesgo relativo (RR) e intervalo de confianza del 95%. La heterogeneidad se estimará con I2 y Chi2.spa
dc.description.researchareaCáncer gástricospa
dc.format.extent59 páginas + anexosspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameUniversidad Nacional de Colombiaspa
dc.identifier.reponameRepositorio Institucional Universidad Nacional de Colombiaspa
dc.identifier.repourlhttps://repositorio.unal.edu.co/spa
dc.identifier.urihttps://repositorio.unal.edu.co/handle/unal/87287
dc.language.isospaspa
dc.publisherUniversidad Nacional de Colombiaspa
dc.publisher.branchUniversidad Nacional de Colombia - Sede Bogotáspa
dc.publisher.facultyFacultad de Medicinaspa
dc.publisher.placeBogotá, Colombiaspa
dc.publisher.programBogotá - Medicina - Especialidad en Gastroenterologíaspa
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dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacionalspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/spa
dc.subject.ddc610 - Medicina y salud::616 - Enfermedadesspa
dc.subject.ddc610 - Medicina y salud::615 - Farmacología y terapéuticaspa
dc.subject.decsNeoplasias Intestinalesspa
dc.subject.decsIntestinal Neoplasmseng
dc.subject.decsMetaanálisis como Asuntospa
dc.subject.decsMeta-Analysis as Topiceng
dc.subject.decsEnfermedades Genéticas Congénitasspa
dc.subject.decsGenetic Diseases, Inborneng
dc.subject.proposalNeoplasias Gástricasspa
dc.subject.proposalGastritis Atróficaspa
dc.subject.proposalMetaplasiaspa
dc.subject.proposalFactores de Riesgospa
dc.subject.proposalMetaanálisisspa
dc.subject.proposalRevisión Sistemáticaspa
dc.subject.proposalStomach Neoplasmseng
dc.subject.proposalGastritiseng
dc.subject.proposalAtrophiceng
dc.subject.proposalMetaplasiaeng
dc.subject.proposalRisk factorseng
dc.subject.proposalMeta-Analysiseng
dc.subject.proposalSystematic revieweng
dc.titleRiesgo de cáncer gástrico en pacientes con gastritis atrófica y metaplasia intestinal en estadios OLGA y OLGIM III y IV: revisión sistemática y metanálisisspa
dc.title.translatedGastric cancer risk in patients with atrophic gastritis and intestinal metaplasia in OLGA and OLGIM stages III and IV: systematic review and meta-analysiseng
dc.typeTrabajo de grado - Especialidad Médicaspa
dc.type.coarhttp://purl.org/coar/resource_type/c_bdccspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/masterThesisspa
dc.type.redcolhttp://purl.org/redcol/resource_type/TMspa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audience.professionaldevelopmentInvestigadoresspa
oaire.accessrightshttp://purl.org/coar/access_right/c_abf2spa

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