Evaluación de diferentes simuladores computacionales y software en la estimación de dosis absorbida en terapia para pacientes de medicina nuclear
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Morales Salcedo, Angela Patricia
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En medicina nuclear se han implementado metodologías de cálculo que producen información importante para la cuantificación de la dosis recibida por los órganos y tejidos durante el diagnóstico y las terapias con radionúclidos, lo que ha llevado al desarrollo de simuladores y software para realizar cálculos de dosis de manera rápida usando esas metodologías como base. El principal inconveniente con estos software es que la mayoría de los usuarios los utilizan sin distinción y en algunos casos como cajas negras. Por esta razón, este trabajo tiene como objetivo analizar las diferencias encontradas entre los principales software y simuladores computacionales basados en la metodología ICRP y la metodología MIRD empleados para el cálculo de dosis absorbida, esto con el fin de evaluar la influencia de los diferentes modelos anatómicos y los factores de conversión de dosis en el calculo de dosis absorbida en pacientes de medicina nuclear. Este estudio usó información biocinética conocida de terapias y diagnóstico mediante los radionúclidos 177Lu y 131I. En las diferencias obtenidas por los diferentes software y simuladores computacionales se observó la influencia de los simuladores anatómicos y los factores de conversión de dosis en el calculo de dosis absorbida en pacientes de medicina nuclear, así mismo se concluyó que el conocimiento de los modelos puede influir en la aplicación de correcciones que permitan el cálculo de dosis más aproximada a los pacientes en estudio.
In nuclear medicine, calculation methodologies have been implemented that produce important information for the quantification of the dose received by organs and tissues during diagnostic and therapies with radionuclides, which has led to the development of simulators and software to perform rapid dose calculations using these methodologies as a basis. The main drawback with these software is that most users use them without distinction and in some cases as black boxes. For this reason, this work aims to analyze the differences found between the main software and computer simulators based on the ICRP methodology and the MIRD methodology used for the calculation of absorbed dose, in order to evaluate the influence of different anatomical models and dose conversion factors in the calculation of absorbed dose in nuclear medicine patients. This study used known biokinetic information of therapies and diagnosis by means of the radionuclides 177Lu and 131I. In the differences obtained by the different software and computational simulators, it was observed the influence of the anatomical simulators and the dose conversion factors in the calculation of absorbed dose in nuclear medicine patients. It was also concluded that the knowledge of the models can influence the application of corrections that allow the calculation of more approximate dose to the patients under study.
In nuclear medicine, calculation methodologies have been implemented that produce important information for the quantification of the dose received by organs and tissues during diagnostic and therapies with radionuclides, which has led to the development of simulators and software to perform rapid dose calculations using these methodologies as a basis. The main drawback with these software is that most users use them without distinction and in some cases as black boxes. For this reason, this work aims to analyze the differences found between the main software and computer simulators based on the ICRP methodology and the MIRD methodology used for the calculation of absorbed dose, in order to evaluate the influence of different anatomical models and dose conversion factors in the calculation of absorbed dose in nuclear medicine patients. This study used known biokinetic information of therapies and diagnosis by means of the radionuclides 177Lu and 131I. In the differences obtained by the different software and computational simulators, it was observed the influence of the anatomical simulators and the dose conversion factors in the calculation of absorbed dose in nuclear medicine patients. It was also concluded that the knowledge of the models can influence the application of corrections that allow the calculation of more approximate dose to the patients under study.